CSF CRH in abstinent cocaine-dependent patients.

Abstract:

:Alterations in stress responsivity may be important in the vulnerability to become cocaine dependent. Thus, an index of hypothalamic-pituitary-adrenal (HPA) axis function was examined in abstinent cocaine-dependent patients. Cerebrospinal fluid (CSF) concentrations of corticotropin releasing factor (CRH) were determined in 29 abstinent cocaine-dependent patients and 66 normal controls. The results showed that there was no significant difference between the abstinent cocaine-dependent patients and normal controls for CSF CRH. Also, CSF CRH concentrations were not related to cocaine-craving scores in a cue-elicited cocaine-craving procedure. Thus, these data suggest that after protracted abstinence from cocaine there is no marked dysregulation of CRH systems as measured by CSF CRH concentrations.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Roy A,Bissette G,Williams R,Berman J,Gonzalez B

doi

10.1016/s0165-1781(03)00040-4

subject

Has Abstract

pub_date

2003-03-25 00:00:00

pages

277-80

issue

3

eissn

0165-1781

issn

1872-7123

pii

S0165178103000404

journal_volume

117

pub_type

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