Abstract:
:Alterations in stress responsivity may be important in the vulnerability to become cocaine dependent. Thus, an index of hypothalamic-pituitary-adrenal (HPA) axis function was examined in abstinent cocaine-dependent patients. Cerebrospinal fluid (CSF) concentrations of corticotropin releasing factor (CRH) were determined in 29 abstinent cocaine-dependent patients and 66 normal controls. The results showed that there was no significant difference between the abstinent cocaine-dependent patients and normal controls for CSF CRH. Also, CSF CRH concentrations were not related to cocaine-craving scores in a cue-elicited cocaine-craving procedure. Thus, these data suggest that after protracted abstinence from cocaine there is no marked dysregulation of CRH systems as measured by CSF CRH concentrations.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Roy A,Bissette G,Williams R,Berman J,Gonzalez Bdoi
10.1016/s0165-1781(03)00040-4subject
Has Abstractpub_date
2003-03-25 00:00:00pages
277-80issue
3eissn
0165-1781issn
1872-7123pii
S0165178103000404journal_volume
117pub_type
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