Abstract：
:B cell lymphoma protein-2 (Bcl-2) may contribute to the pathophysiology of schizophrenia in the brain. The aim of this study was to investigate the serum levels of Bcl-2 in schizophrenic patients in an acute phase, and evaluate Bcl-2 level changes after antipsychotic treatment. We consecutively enrolled 41 schizophrenia patients in an acute phase; 28 were followed up with a 4-week antipsychotic treatment. Serum Bcl-2 levels were measured with assay kits. All patients were evaluated by examining the correlation between Bcl-2 levels and Positive and Negative Syndrome Scale (PANSS) scores, using Pearson correlation coefficients. In schizophrenic patients in an acute phase, positive PANSS subscores were significantly negatively correlated with Bcl-2 levels. In addition, we found Bcl-2 levels had a significantly negative correlation with PANSS total scores and positive subscores in male patients in an acute phase. Using the paired t-test, we found no significant changes in Bcl-2 levels in schizophrenia patients who had received the 4-week treatment with antipsychotic drugs (n=28). In conclusion, our results suggest that Bcl-2 might be an indicator of schizophrenia severity in the acute phase. In addition, Bcl-2 levels might be associated with positive symptoms in male patients with schizophrenia.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Tsai MC,Liou CW,Lin TK,Lin IM,Huang TLdoi
10.1016/j.psychres.2013.08.032subject
Has Abstractpub_date
2013-12-30 00:00:00pages
735-8issue
3eissn
0165-1781issn
1872-7123pii
S0165-1781(13)00492-7journal_volume
210pub_type
杂志文章abstract：:Although social skills training (SST) is an effective approach for improving social skills for schizophrenia, the motivational deficit attenuates its efficacy. Virtual reality (VR) applications have allowed individuals with mental disabilities to enhance their motivation for rehabilitation. We compared SST using VR ro...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2011-05-31 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.psychres.2018.03.024
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更新日期：1999-04-26 00:00:00
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pub_type： 杂志文章
doi：10.1016/0165-1781(90)90131-n
更新日期：1990-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0165-1781(88)90015-7
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章
doi：10.1016/j.psychres.2017.09.008
更新日期：2018-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2021-01-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2019-02-01 00:00:00
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doi：10.1016/j.psychres.2016.12.044
更新日期：2017-03-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.04.028
更新日期：2012-12-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.12.009
更新日期：2014-02-28 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.12.028
更新日期：2011-05-15 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.12.011
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.07.043
更新日期：2018-05-01 00:00:00
