Abstract：
:Serotonergic abnormalities have been regularly reported in the brains of suicide victims. Because of evidence that pineal function is altered in depressed subjects and that serotonin-releasing axons may innervate the pineal, we assayed tritiated serotonin binding in a series of control and suicide pineals. High affinity binding was present, and there were apparent differences between some suicides and controls.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Sparks DL,Little KYdoi
10.1016/0165-1781(90)90131-nsubject
Has Abstractpub_date
1990-04-01 00:00:00pages
19-28issue
1eissn
0165-1781issn
1872-7123pii
0165-1781(90)90131-Njournal_volume
32pub_type
杂志文章abstract：:Childhood adversity is associated with a range of mental disorders, functional impairment and higher health care costs in adulthood. In this study we evaluated if childhood adversity was predictive of adverse clinical and functional outcomes and health care costs in a sample of patients at ultra-high risk (UHR) for de...
journal_title：Psychiatry research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.psychres.2016.11.014
更新日期：2017-01-01 00:00:00
abstract：:Parkinson's disease (PD) has broadly been associated with mild cognitive impairment (PDMCI) and dementia (PDD). Researchers have studied surrogate, neuroanatomic biomarkers provided by magnetic resonance imaging (MRI) that may help in the early diagnosis of this condition. In this article, four classification models (...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2012.06.001
更新日期：2013-08-30 00:00:00
abstract：:The absence of assessment tools incorporating different cultural models of mental illness is a major barrier to recruiting ethnic minorities into clinical trials, reducing generalisability of findings and potentially increasing disparities in access to evidence-based care. This study aimed to develop and validate a ne...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.03.013
更新日期：2018-05-01 00:00:00
abstract：:There is little information on gender differences in general mental health, smoking, drinking and chronic diseases in Chinese elderly. We examined the gender differences in general mental health, smoking, drinking and a number of chronic diseases in a large Chinese old population. Multistage stratified cluster samplin...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.02.007
更新日期：2017-05-01 00:00:00
abstract：:Defensive responding in schizotypy questionnaires might depend on context. Students completed a schizotypy questionnaire in a "psychiatric" context or a "creativity" context. Positive, but not negative, schizotypy scores were lower in the psychiatry than in the creativity group, but findings applied mainly to male par...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2005.06.006
更新日期：2005-09-15 00:00:00
abstract：:This study examined whether cognitive measures of response inhibition derived from the AX-CPT are able to differentiate between adult attention deficit/hyperactivity disorder (ADHD), borderline personality disorder (BPD), and healthy controls (HC). Current DSM-IV-TR symptoms of ADHD and BPD were assessed by structured...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.12.034
更新日期：2014-03-30 00:00:00
abstract：:Alcohol abuse coincides with a wide variety of clinical, sociological and psychological features and symptoms. Gastrointestinal symptoms are also very common in alcoholics, but the reason is unclear. We aimed to determine the prevalence of alexithymia in alcoholics and furthermore if gastrointestinal symptoms were ass...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2004.07.001
更新日期：2004-11-30 00:00:00
abstract：:Early life stress (ELS) confers risk for psychiatric illness. Previous literature suggests ELS is associated with decreased resting-state functional connectivity (rs-FC) in adulthood, but there are no studies of resting-state neuronal activity in this population. This study investigated whether ELS-exposed individuals...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2013.07.013
更新日期：2013-12-30 00:00:00
abstract：:Most investigators have measured binding of 3H-imipramine to platelet membranes, but some of the preparations may have contained varying proportions of intracellular protein because of contamination with incompletely lysed platelets. Since binding to membranes has been expressed with reference to the amount of protein...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(88)90070-4
更新日期：1988-11-01 00:00:00
abstract：:Evidence suggests that suicidal behaviour arises from one's attempt to escape from unbearable situations or unbearable thoughts and feelings. These feelings of entrapment are usually assessed via the 16-item Entrapment Scale, but this is too long for routine use in clinical practice. The aim of this study was to devel...
journal_title：Psychiatry research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.psychres.2020.112765
更新日期：2020-02-01 00:00:00
abstract：:Evidence shows that BDNF may regulate activity-dependent forms of synaptic plasticity underlying learning and memory. Previous studies reported low BDNF levels and cognitive impairment in the early stage of schizophrenia. Our current study aimed to explore the association between serum BDNF and cognitive functions in ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.02.034
更新日期：2018-05-01 00:00:00
abstract：:Although the fear of being scrutinized by others in a social context is a key symptom in social anxiety disorder (SAD), the neural processes underlying the perception of scrutiny have not previously been studied by functional magnetic resonance imaging (fMRI). We used fMRI to map brain activation during a perception-o...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2011.10.008
更新日期：2012-06-30 00:00:00
abstract：:The present study aimed to provide preliminary evaluation of the effectiveness of a brief CBT intervention focusing on relapse prevention and positive symptom in a Chinese first episode schizophrenia (FES) population. This randomized controlled trial recruited eighty outpatients with FES (as determined using the DSM-I...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2018.12.130
更新日期：2019-02-01 00:00:00
abstract：:We report the initial results of the first controlled double-blind trial of nimodipine, a calcium channel antagonist, in the acute and prophylactic treatment of patients with treatment-refractory affective dysregulation. Active drug nimodipine (A) was substituted for placebo (B) in 12 patients. Patients were studied i...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0165-1781(93)90066-p
更新日期：1993-12-01 00:00:00
abstract：:Plasma levels of homovanillic acid (HVA), a dopamine metabolite, were examined in 19 psychiatric inpatients during maintenance treatment on neuroleptic medications. A significant positive correlation was found between the level of HVA and the severity of tardive dyskinesia (TD) in these patients. Seven patients had th...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(83)90046-x
更新日期：1983-07-01 00:00:00
abstract：:The Pittsburgh Sleep Quality Index (PSQI) is a widely used, comprehensive self-report measure of sleep quality and impairment, which has demonstrated good psychometric properties within various populations, including older adults. However, the psychometric properties of the PSQI and its component scores have not been ...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2012.03.045
更新日期：2012-08-30 00:00:00
abstract：:Schizophrenia is considered a connectivity disorder. Further, the functional connectivity (FC) of the default-mode network (DMN) has gained the interest of researchers. However, few studies have been conducted on the abnormal connectivity of DMN in early-onset schizophrenia (EOS). In this study, the key brain regions ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113578
更新日期：2021-01-01 00:00:00
abstract：:Considerable evidence suggests that there is a relationship between pathologic aggressive behavior and low cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) in both humans and non-human primates. The purpose of this investigation is to examine the relationship bet...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(99)00022-0
更新日期：1999-04-19 00:00:00
abstract：:Dewan asserted 20 years ago that a bedside light could shorten and regularize the menstrual cycle among women with long and irregular menstrual patterns. To replicate this, seven volunteers slept with a 100-watt bulb by the bedside from days 13-17 of their menstrual cycles, while nine controls similarly used a dim red...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/0165-1781(90)90067-f
更新日期：1990-08-01 00:00:00
abstract：:Energy metabolism and immunity are characterized as abnormal in schizophrenia. Because these two systems are highly coordinated, we measured expression of prototypic obesogenic and immunogenic genes in freshly harvested PBMC from controls and participants with schizophrenia. We report significant increases in PPARγ, S...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.11.007
更新日期：2015-01-30 00:00:00
abstract：:In order to measure the intrafamilial correlation for age at onset and to examine gender resemblance among bipolar siblings, we assessed a sample of 130 bipolar patients belonging to 59 multiple affected sibships. To study the intrafamilial resemblance for age at onset and gender, we used the intraclass correlation an...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(98)00087-0
更新日期：1998-11-16 00:00:00
abstract：:Accumulating data show that probiotics may be beneficial in reducing depressive symptoms. We conducted an updated meta-analysis and evaluated the effects of probiotics on depressive symptoms. A systematic search of six databases was performed, and the results were reported according to Preferred Reporting Items for Sy...
journal_title：Psychiatry research
pub_type： 杂志文章,meta分析
doi：10.1016/j.psychres.2019.112568
更新日期：2019-12-01 00:00:00
abstract：:Two animal tests of anxiety (the elevated plus-maze and the social interaction test) were used to investigate the effects of several antipanic agents. In the elevated plus-maze, the triazolobenzodiazepines adinazolam (2 and 5 mg/kg) and alprazolam (1 mg/kg), tested after 5 days of pretreatment, demonstrated significan...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(88)90161-8
更新日期：1988-07-01 00:00:00
abstract：:Anhedonia is a symptom that plays a significant role in theories of illness such as depression and schizophrenia. Some previous research suggests that participants who report high levels of social/physical anhedonia also show deficits in both self-report and physiological measures of emotional processing, particularly...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2005.07.030
更新日期：2006-08-30 00:00:00
abstract：:Excessive interpersonal dependency has been described in depression and addictive disorders. Moreover, excessive dependency and suicidality are linked in psychiatric subjects, but their relationships have not been studied in specific addictions. Separate samples of female anorectic patients (n=150), female bulimic pat...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2004.06.022
更新日期：2005-11-15 00:00:00
abstract：:Schizophrenia is considered a neurodevelopmental disorder, but whether the adolescent period, proximal to onset, is associated with aberrant development in individuals at clinical high risk (CHR) for psychosis is incompletely understood. While abnormal gray and white matter development has been observed, alterations i...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2013.08.004
更新日期：2014-01-30 00:00:00
abstract：:Stress results in a variety of neuroendocrine, immune and behavioral responses and represents a risk factor for many disorders. Following exposure to stress, glucocorticoids are secreted from the adrenal cortex and act via the ligand-activated glucocorticoid receptor (GR). Several polymorphisms of the GR-encoding gene...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.10.001
更新日期：2016-12-30 00:00:00
abstract：:There is a clinical need for objective evidence-based measures that are sensitive and specific to ADHD when compared with other neurodevelopmental disorders. This study evaluated the incremental validity of adding an objective measure of activity and computerised cognitive assessment to clinical rating scales to diffe...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.06.042
更新日期：2016-09-30 00:00:00
abstract：:Two different initial dosing regimens with clomipramine (CMI) were used to compare early response indicators and dose strategies. Thirty-two inpatients with major depressive disorder were randomized in a double-blind protocol. The pulse-loading group received 150 and 200 mg of CMI on 2 consecutive evenings and then re...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0165-1781(94)90004-3
更新日期：1994-11-01 00:00:00
abstract：:Some, but not all studies have reported that a single dose of benzodiazepine affects growth hormone (GH) and cortisol secretion in healthy volunteers. The majority of studies that found GH elevations after benzodiazepine administration did not use placebo trials. The present placebo-controlled investigation determined...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/0165-1781(86)90014-4
更新日期：1986-08-01 00:00:00
