Abstract：
:Schizophrenia is considered a neurodevelopmental disorder, but whether the adolescent period, proximal to onset, is associated with aberrant development in individuals at clinical high risk (CHR) for psychosis is incompletely understood. While abnormal gray and white matter development has been observed, alterations in functional neuroimaging (fMRI) parameters during adolescence as related to conversion to psychosis have not yet been investigated. Twenty CHR individuals and 19 typically developing controls (TDC), (ages 14-21), were recruited from the Center for Assessment and Prevention of Prodromal States (CAPPS) at UCLA. Participants performed a Sternberg-style verbal working memory (WMem) task during fMRI and data were analyzed using a cross-sectional design to test the hypothesis that there is a deviant developmental trajectory in WMem associated neural circuitry in those at risk for psychosis. Eight of the CHR adolescents converted to psychosis within 2 years of initial assessment. A voxel-wise regression examining the relationship between age and activation revealed a significant group-by-age interaction. TDC showed a negative association between age and functional activation in the WMem circuitry while CHR adolescents showed a positive association. Moreover, CHR patients who later converted to overt psychosis showed a distinct pattern of abnormal age-associated activation in the frontal cortex relative to controls, while non-converters showed a more diffuse posterior pattern. Finding that age related variation in baseline patterns of neural activity differentiate individuals who subsequently convert to psychosis from healthy subjects suggests that these differences are likely to be clinically relevant.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Karlsgodt KH,van Erp TG,Bearden CE,Cannon TDdoi
10.1016/j.pscychresns.2013.08.004subject
Has Abstractpub_date
2014-01-30 00:00:00pages
21-9issue
1eissn
0165-1781issn
1872-7123pii
S0925-4927(13)00217-5journal_volume
221pub_type
杂志文章abstract：:Patient-rated life satisfaction and observer-rated quality of life (ORQOL) appear to have different determinants in patients with schizophrenia, although most studies conducted to date have used cross-sectional methods or related clinical dimensions at one time point with quality of life (QOL) measured at another. The...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(03)00099-4
更新日期：2003-07-15 00:00:00
abstract：:Because estrogen may influence brain blood flow and metabolism in older adults, we used positron emission tomography to evaluate cerebral glucose metabolic change in post-menopausal women and men. Women estrogen users (n=4), women non-users (n=8) and men (n=10) were scanned at baseline and two years later. Analyses fo...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(01)00084-1
更新日期：2001-07-01 00:00:00
abstract：:Research on outcomes from psychiatric disorders has highlighted the importance of expressed emotion (EE), but its cost-effective measurement remains a challenge. This article describes development of the Family Attitude Scale (FAS), a 30-item instrument that can be completed by any informant. Its psychometric characte...
journal_title：Psychiatry research
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更新日期：1997-05-30 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,meta分析
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abstract：:This study sought to identify whether subjects with a family history (FH + ) of alcoholism had changes in regional cerebral blood volume (rCBV) after an alprazolam challenge which distinguished them from subjects without a family history (FH -) of alcoholism using functional MRI (fMRI). Twelve FH + and eight FH - subj...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1998-05-20 00:00:00
abstract：:In the past decade, not just right experiences (NJRE) and incompleteness (INC) have attracted renewed interest as putative motivators of symptoms in obsessive-compulsive disorder (OCD), beyond harm avoidance (HA). This study examines, in 267 non-clinical undergraduates and 47 OCD patients, the differential contributio...
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2017-04-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2018-11-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
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更新日期：1980-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-12-30 00:00:00
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pub_type： 杂志文章
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abstract：:Acute Stress Disorder (ASD) was first included in the DSM-IV in 1994. It was proposed to account for traumatic responding in the early post trauma phase and to act as an identifier for later Posttraumatic Stress Disorder (PTSD). Unlike PTSD it included a number of dissociative indicators. The revised DSM-5 PTSD criter...
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更新日期：2016-02-28 00:00:00
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pub_type： 杂志文章
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更新日期：1984-03-01 00:00:00
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更新日期：2013-10-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2012-05-31 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2003-11-30 00:00:00
abstract：:The aims of this study were to: 1) examine the relationship between being bullied and depressive symptoms; 2) explore whether the three mentioned sources of social support moderated this association; and 3) examine gender differences in the moderating effects of social support on bullying-associated depressive symptom...
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更新日期：2020-02-01 00:00:00
abstract：:Bipolar Disorder (BD) is associated with impairment in a number of areas including poor work functioning, often despite the remission of mood symptoms. The present study aimed to examine the role of sleep disturbance and cognitive functioning in occupational impairment in BD. Twenty-four euthymic BD participants and 2...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.09.051
更新日期：2015-12-15 00:00:00
abstract：:Pituitary volume in humans has been reported to change size in response to experimental manipulations of photoperiod, and to be increased during an episode of non-seasonal major depression. We wanted to determine whether pituitary volume changes either across the seasons or during an episode of winter depression. Nine...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(97)00015-2
更新日期：1997-07-04 00:00:00
