Abstract：
:In order to measure the intrafamilial correlation for age at onset and to examine gender resemblance among bipolar siblings, we assessed a sample of 130 bipolar patients belonging to 59 multiple affected sibships. To study the intrafamilial resemblance for age at onset and gender, we used the intraclass correlation and the sibship method, respectively. Within the whole sample, age at onset for affected siblings was correlated (rho = 0.42, P = 0.0001). Gender was randomly distributed among bipolar sibships, demonstrating the absence of gender resemblance among affected siblings. The existence of an intrafamilial correlation for age at onset among bipolar siblings suggests that this variable may assist in the identification of more heritable forms of the illness. No intrafamilial correlation was found for the gender of affected siblings, suggesting that familial vulnerability factors are not gender-specific.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Leboyer M,Bellivier F,McKeon P,Albus M,Borrman M,Perez-Diaz F,Mynett-Johnson L,Feingold J,Maier Wdoi
10.1016/s0165-1781(98)00087-0subject
Has Abstractpub_date
1998-11-16 00:00:00pages
125-31issue
2eissn
0165-1781issn
1872-7123pii
S0165178198000870journal_volume
81pub_type
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