Abstract：
:In vivo studies of dopamine D2 receptor occupancy with atypical antipsychotics have suggested good clinical efficacy at occupancy rates less than those observed with typical neuroleptics, and few extrapyramidal side effects (EPS), possibly even at high levels of D2 occupancy. We used [123I]IBZM-SPECT to investigate striatal D2 receptor occupancy in 10 schizophrenic patients who were treated with both a low (5 mg) and a high dose (20 mg) of the novel antipsychotic olanzapine without concomitant medications. The mean D2 occupancy at 5 mg was 59.8% (range 33-81%); the mean D2 occupancy at 20 mg was 82.8% (range 56-97%). Although the D2 occupancy rates on 5 and 20 mg olanzapine were significantly different (P < 0.001), there were no significant differences in clinical ratings for psychiatric symptoms or extrapyramidal side effects between the two doses of olanzapine. These data suggest that: (1) olanzapine doses below those used routinely occupy D2 receptors at levels approaching those associated with therapeutic response; (2) higher doses produce relatively high levels of D2 occupancy rates; and (3) EPS are mild even at relatively high levels of D2 occupancy.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Raedler TJ,Knable MB,Lafargue T,Urbina RA,Egan MF,Pickar D,Weinberger DRdoi
10.1016/s0925-4927(99)00010-4subject
Has Abstractpub_date
1999-04-26 00:00:00pages
81-90issue
2eissn
0165-1781issn
1872-7123journal_volume
90pub_type
杂志文章abstract：:This report of a pilot study examines 29 pairs of twins from a population-based registry on whom four domains of schizotypy have been measured: personal interview using the Structured Interview for Schizotypy, self-report questionnaire formed from eight published self-report scales, attentional battery of eight indivi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(91)90114-5
更新日期：1991-01-01 00:00:00
abstract：:The aim of this study is to investigate whether mismatch negativity (MMN) is associated with functional status or is a state-independent trait for schizophrenia. We assessed MMN in 26 patients with schizophrenia, 20 healthy subjects with high genetic loading, and 48 healthy controls. Repeated measures analysis of vari...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2014.02.012
更新日期：2014-04-30 00:00:00
abstract：:Cannabis use has been associated with a continuum of psychotic experiences. However, it is unclear whether mood and anxiety symptoms account for increases in attenuated positive psychotic symptoms (APPS) among cannabis users. We predicted that depression and anxiety symptoms would mediate the relation between cannabis...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.03.040
更新日期：2014-08-15 00:00:00
abstract：:We aim to replicate AKT1 gene variants studies using Malaysian samples. Seven AKT1 single nucleotide polymorphisms (SNPs) were studied in 417 patients and 429 controls. Haplotype showed significant association (p=0.036) with schizophrenia, especially in Malays and Indians. Meta-analysis of rs2494732 showed significant...
journal_title：Psychiatry research
pub_type： 杂志文章,meta分析
doi：10.1016/j.psychres.2013.05.017
更新日期：2013-10-30 00:00:00
abstract：:This study explored the involvement of two key psychological factors, drinking motives and impulsivity traits, in binge drinking. On the basis of a large screening phase (N=4424), 867 binge drinkers were selected and were first compared with 924 non-binge drinkers. Then, a cluster analysis was performed, focusing on t...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.01.068
更新日期：2017-04-01 00:00:00
abstract：:Voxel-based morphometry (VBM) is an objective whole-brain technique for characterizing regional cerebral volume and tissue concentration differences in structural magnetic resonance images. In the current study, we used VBM to examine possible cerebral gray matter abnormalities in patients with posttraumatic stress di...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2005.09.006
更新日期：2006-01-30 00:00:00
abstract：:The purpose of this research was to examine the relationship between sensation seeking and online poker gambling in a community sample of adult online poker players, when controlling for age, gender, anxiety and depression. In total, 288 online poker gamblers were recruited. Sociodemographic data, gambling behavior (C...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.03.024
更新日期：2018-06-01 00:00:00
abstract：:We examined associations between social connections and non-suicidal self-injury (NSSI) among transgender/gender non-conforming (TGNC) youth. Data came from the 2016 Minnesota Student Survey (N = 2168). Logistic regression analyses determined connectedness factors associated with any past-year NSSI and repetitive NSSI...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.06.068
更新日期：2018-10-01 00:00:00
abstract：:Abnormalities of both the spontaneous and the stimulated release of growth hormone (GH) have been described in patients with endogenous depression. In this study, six unmedicated male patients with endogenous depression (ICD 296.1/3) were compared with six age-matched healthy men. Levels of GH were determined at 15-mi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(93)90080-z
更新日期：1993-06-01 00:00:00
abstract：:Psychiatric symptoms have been reported for individuals who experience chronic exposure to low levels of organic solvents. However, it is not known what proportion of such individuals experience psychiatric disorder; which specific disorders may be characteristic of this population; or whether bioaccumulation of lead ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(00)00217-1
更新日期：2000-12-27 00:00:00
abstract：:Major depression (MD) is a common psychiatric disorder and one of its most serious symptoms is suicidal ideation. Six polymorphisms in four genes related to the serotonin system, including the HTTLPR and HTTVNTR in the SLC6A4 gene, rs6295 in the HTR1A gene, rs11568817 and rs130058 in the HTR1B gene, and rs6313 in the ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.12.006
更新日期：2009-12-30 00:00:00
abstract：:Patients with bipolar mania often require re-hospitalization, which can be a social-economic burden. This study aimed to investigate the factors affecting time to re-hospitalization for inpatients with acute bipolar mania. In this 6-year naturalistic study we reviewed the charts of inpatients with acute bipolar mania....
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.10.073
更新日期：2018-12-01 00:00:00
abstract：:Although deep grey matter (GM) involvement in multiple sclerosis (MS) is well documented, in-vivo multi-parameter magnetic resonance imaging (MRI) studies and association with detailed cognitive measures are limited. We investigated volumetric, diffusion and perfusion metrics in thalamus, hippocampus, putamen, caudate...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2015.10.004
更新日期：2015-12-30 00:00:00
abstract：:Growing evidence supports a continuum model of psychosis, with mild psychotic symptoms being frequently experienced by the general population. Moreover, believing in the continuum model correlates with less stigmatization of schizophrenia. This study explores whether continuum beliefs are a valid construct and develop...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.04.085
更新日期：2016-07-30 00:00:00
abstract：:Our aim is to assess cross-national variations in prevalence of clinically relevant depression and to examine the relationships of social and health factors with depression in five diverse populations of older adults, from Canada, Brazil, Colombia and Albania. We used the data from the International Mobility in Aging ...
journal_title：Psychiatry research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.psychres.2016.04.096
更新日期：2016-07-30 00:00:00
abstract：:Correlations between cerebrospinal fluid (CSF) concentrations of monoamine metabolites (MAM) and brain structure have been described in schizophrenia, but not in alcoholism. To investigate the relationship between monoaminergic transmission and brain structure in alcoholism, the metabolites of dopamine (homovanillic a...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(02)00084-7
更新日期：2003-01-20 00:00:00
abstract：:Eating disorder (ED) patients have severe disturbances in the perception of body shape and weight. The authors investigated brain activation patterns during the perception of distorted body images in various subtypes of ED. Participants comprised 33 patients with EDs (11 with restricting-type anorexia nervosa (AN-R), ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2009.09.001
更新日期：2010-03-30 00:00:00
abstract：:Platelets may have an important role in the development of cardiovascular disease (CVD) as a result of chronic stress. We conducted a pilot study to evaluate the effect of posttraumatic stress disorder (PTSD) on baseline platelet activation. Platelet-leukocyte aggregates (PLA) and CD63 expression were measured by flow...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.05.004
更新日期：2007-03-30 00:00:00
abstract：:A key characteristic of bipolar disorder is fluctuation in mood symptoms and functional capacity, yet assessment of bipolar symptomatology often relies heavily on interval measurement that is unable to capture the full range of daily symptom variability and severity. The current study provides a detailed analysis of t...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.04.047
更新日期：2014-08-30 00:00:00
abstract：:The dysconnectivity hypothesis proposes that abnormal resting state connectivity within the default-mode network (DMN) plays a key role in schizophrenia. Little is known, however, about alterations of the network homogeneity (NH) of the DMN in unaffected siblings of patients with schizophrenia. Unaffected siblings hav...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2014.08.014
更新日期：2014-12-30 00:00:00
abstract：:In schizophrenia, psychomotor slowing and stereotypy are poorly delineated from cognitive deficits like diminished processing speed. Inpatients' performance outcomes on a line-copying task, a task assessing stereotypy and a processing-speed task are compared. Results suggested that psychomotor slowing and stereotypy a...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.01.017
更新日期：2008-10-30 00:00:00
abstract：:Cognitive impairment is a frequent complication of advanced human immunodeficiency virus-1 (HIV-1) infection. However, structural imaging of the brain has not revealed abnormalities that precede the onset of clinical abnormalities. Cranial magnetic resonance (MR) studies were performed in 28 male subjects with intrave...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(93)90047-k
更新日期：1993-05-01 00:00:00
abstract：:Depression is associated with three distinct alterations in memory functioning: mood-congruent recall, over-generality, and intrusive memories. These concern the autobiographical memory system, yet no previous studies have examined the neural correlates of autobiographical memory function in depression. In the present...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2011.08.008
更新日期：2012-02-28 00:00:00
abstract：:This study was designed to examine the prevalence and the risk factors of poor sleep quality in 4318 incoming university students in Taiwan. The test battery comprised a self-administered structured questionnaire, including items related to personal medical history and lifestyle habits, the Measurement of Support Func...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2011.08.011
更新日期：2012-05-30 00:00:00
abstract：:Stigmatizing beliefs about mental illness can be a daily struggle for people with schizophrenia. While investigations into the impact of internalizing stigma on negative symptoms have yielded mixed results, resistance to stigmatizing beliefs has received little attention. In this study, we examined the linkage between...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.11.020
更新日期：2014-02-28 00:00:00
abstract：:Evidence of subtle neuropsychological deficits in relatives of schizophrenic probands (REL-SZs) suggests that these are risk indicators for schizophrenia, but little is known about whether neuropsychological performance in REL-SZs differs from that in other groups of relatives. We compared neuropsychological function ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(98)00042-0
更新日期：1998-07-13 00:00:00
abstract：:Posttraumatic stress disorder (PTSD) and social anxiety disorder (SAD) are highly comorbid (Collimore et al., 2010). Trauma may present a shared environmental factor contributing to the development of comorbidity; however, existent research has been hampered by use of restrictive samples and limitations in the range o...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.10.036
更新日期：2016-12-30 00:00:00
abstract：:Although several studies have detected differences in clinical features among specific phobias, there is a shortage of detailed national data on the on the DSM-IV SP subtypes, particularly in the Asian population. To examine the prevalence, demographic and other correlates, and co-morbidities of DSM-IV SP subtypes in ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.12.025
更新日期：2013-10-30 00:00:00
abstract：:The aim of this study was to compare childhood trauma scores domains between Major Depressive Disorder (MDD) patients with and without suicide risk. This is cross-sectional study including a clinical sample of adults (18-60 years) diagnosed with MDD through the Mini International Neuropsychiatric Interview Plus versio...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.11.002
更新日期：2016-12-30 00:00:00
abstract：:Computed tomography was used to compare the following three groups: obsessive-compulsive disorder (OCD) patients with high scores on a soft neurological sign examination, OCD patients with low soft neurological sign scores, and control subjects. Neuranatomical structures were measured using quantitative volumetric ana...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0925-4927(93)90026-e
更新日期：1993-10-01 00:00:00
