Abstract：
:Eating disorder (ED) patients have severe disturbances in the perception of body shape and weight. The authors investigated brain activation patterns during the perception of distorted body images in various subtypes of ED. Participants comprised 33 patients with EDs (11 with restricting-type anorexia nervosa (AN-R), 11 with binging-purging type anorexia nervosa (AN-BP), 11 with bulimia nervosa (BN)) and 11 healthy women. Functional magnetic resonance imaging was used to examine cerebral response to morphed images of subjects' own bodies, as well as that of another woman. The amygdala was significantly activated in AN-R patients, AN-BP patients, and healthy women in response to their own fat-image, but this did not occur in BN patients. The prefrontal cortex (PFC) was significantly activated in AN-BP patients and healthy women, but not in AN-R and BN patients. Our results showed that the various EDs are different with respect to significant activation of the amygdala and PFC during the processing of participants' own fat-image. Brain activation pattern differences between the various EDs may underlie cognitive differences with respect to distorted body image, and therefore might reflect a general failure to represent and evaluate one's own body in a realistic fashion.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Miyake Y,Okamoto Y,Onoda K,Kurosaki M,Shirao N,Okamoto Y,Yamawaki Sdoi
10.1016/j.pscychresns.2009.09.001subject
Has Abstractpub_date
2010-03-30 00:00:00pages
183-92issue
3eissn
0165-1781issn
1872-7123pii
S0925-4927(09)00198-Xjournal_volume
181pub_type
杂志文章abstract：:Few investigators have applied the working memory theory to studies on abstinent chronic alcoholics, though it has been reported that the deficits in short-term memory appear to be specific to visuo-spatial and problem-solving tasks. In the present study, we recorded ERPs from 40 male control subjects and 78 alcoholic...
journal_title：Psychiatry research
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