Abstract：
:Little is known regarding between-subject variability in the subjective effects of first cocaine use. This study retrospectively assesses the subjective effects of first cocaine use in 160 current treatment-seeking cocaine use disorder patients. Subjective effects of first cocaine use were evaluated with an ad-hoc questionnaire used for cannabis effects. A principal component analysis (PCA) was performed, with resulting factors correlated with clinical variables (α = 0.05). Four factors emerged in the PCA, namely Anxiety (accounting for 21.5% of questionnaire variance), Disinhibition (17.3%), Tachypsychia (16%) and Calmness (13%). Male gender was associated with Disinhibition and Tachypsychia. Cocaine severity factors were associated with Disinhibition, Tachypsychia and Calmness. Opiate, sedative and poppers uses were associated with Anxiety, Tachypsychia and Calmness. The retrospective assessment of the subjective effects of first cocaine use shows significant variability. The different dimensions of subjective first effects are influenced by age, gender and previous substance use history, as well as characteristics of first cocaine use and cocaine-related outcomes.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Karsinti E,Piani K,Zerdazi EH,Maskos U,Faure P,Romo L,Bellivier F,Brousse G,Lépine JP,Bloch V,Vorspan Fdoi
10.1016/j.psychres.2018.03.058subject
Has Abstractpub_date
2018-06-01 00:00:00pages
210-216eissn
0165-1781issn
1872-7123pii
S0165-1781(17)30725-4journal_volume
264pub_type
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