Abstract：
:Both major depressive disorders (MDD) and schizophrenia (SZ) have been associated with reductions in slow-wave (Stages 3 and 4) sleep, although these findings are controversial. The present study compared quantitative EEG measures of slow-wave activity (0.5-4 Hz) during non-REM (NREM) sleep among age-matched, symptomatic but unmedicated, depressed, schizophrenic and healthy control men (n=13/group). The amplitude of slow-wave activity (SWA) in the first NREM sleep period was significantly lower in both the MDD and SZ groups compared with controls. However, the time course of SWA, its accumulation and dissipation over all NREM sleep time, was abnormal in the MDD group but not in those with SZ. These findings suggest that the regulation of SWA is impaired in men with MDD but not in SZ. Thus, although those with SZ show reduced amplitude SWA in the first NREM period, there is no evidence that homeostatic regulation of SWA is impaired in this psychiatric group.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Hoffmann R,Hendrickse W,Rush AJ,Armitage Rdoi
10.1016/s0165-1781(00)00181-5subject
Has Abstractpub_date
2000-09-11 00:00:00pages
215-25issue
3eissn
0165-1781issn
1872-7123pii
S0165-1781(00)00181-5journal_volume
95pub_type
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