Abstract:
:Gilles de la Tourette Syndrome (GTS) and obsessive-compulsive disorder (OCD) share obsessive-compulsive phenomena. The aims of this study were to compare the OC symptom distribution between GTS and OCD and to investigate whether a subdivision of these phenomena into obsessions, compulsions and 'impulsions' is useful in distinguishing GTS and OCD patients. Thirty-two GTS, 31 OCD (10 with tics, 21 without tics) and 29 control subjects were studied using the Leiden repetitive behaviors semi-structured interview to assess GTS as well as OCD-related behaviors. Each reported repetitive thought or action was evaluated on the presence of anxiety and on goal-directedness. This information was used to define whether the behavior was an obsession, compulsion, or 'impulsion'. Both the GTS and OCD study groups showed higher scores than control subjects on rating scales measuring depression, OC behavior and anxiety. In GTS, Y-BOCS severity scores and trait anxiety were lower than in the OCD groups. Furthermore, GTS patients differed from OCD patients in the distribution of symptoms. Aggressive repetitive thoughts, contamination worries and washing behaviors were reported more frequently by tic-free OCD, while mental play, echophenomena, touching and (self)-injurious behaviors were reported more frequently by GTS. OCD individuals with tics were intermediate, but closer to tic-free OCD. GTS individuals reported significantly more 'impulsions' and fewer obsessions and compulsions than OCD individuals with and without tics. Factor analysis revealed three factors accounting for 44% of the variance, resulting in an 'impulsive' factor related to GTS, a 'compulsive' factor related to OCD and an 'obsessive' factor related to tic-free OCD. In conclusion, OCD individuals reported more anxiety and goal-directedness associated with their behaviors than did GTS subjects. The distinction between obsessions, compulsions and impulsions is of importance in identifying Tourette-related vs. non-Tourette-related repetitions.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Cath DC,Spinhoven P,Hoogduin CA,Landman AD,van Woerkom TC,van de Wetering BJ,Roos RA,Rooijmans HGdoi
10.1016/s0165-1781(01)00219-0subject
Has Abstractpub_date
2001-03-25 00:00:00pages
171-85issue
2eissn
0165-1781issn
1872-7123pii
S0165-1781(01)00219-0journal_volume
101pub_type
杂志文章abstract::Impaired vocational functioning is a hallmark of schizophrenia, but limited research has evaluated the relationships between work and schizophrenia-spectrum personality disorders, including schizotypal (SPD) and paranoid personality disorder (PPD). This study compared employment history and job characteristics of 174 ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2013.06.019
更新日期:2013-12-15 00:00:00
abstract::Obesity depends on homeostatic and hedonic food intake behavior, mediated by brain plasticity changes in cortical and subcortical structures. The aim of this study was to investigate cortical thickness and subcortical volumes of regions related to food intake behavior in a healthy young adult sample with obesity. Thir...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2013.06.004
更新日期:2013-11-30 00:00:00
abstract::Platelet serotonin levels were measured in several psychiatric disorders to determine whether they distinguish among major depressive disorder (one or more depressive episodes and no manic episodes), dysthymic disorder (depressive neurosis), and schizophrenic and paranoid disorders. Serotonin levels in 141 subjects we...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(84)90056-8
更新日期:1984-10-01 00:00:00
abstract::Dysthymic disorder is a chronic depressive condition with considerable psychosocial impairment. Even if DD patients respond to various antidepressant medications, there has been little systematic study on antidepressant-refractory DD. Only a few trials have evaluated the effects of treatment on psychosocial functionin...
journal_title:Psychiatry research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0165-1781(02)00188-9
更新日期:2002-10-10 00:00:00
abstract::This report explores the relationship between age of first onset of major depression and other demographic and clinical features in the first 1500 patients entering the Sequenced Treatment Alternative to Relieving Depression (STAR*D) study. Outpatients, 18-75 years of age, with nonpsychotic major depressive disorder (...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2004.07.004
更新日期:2004-12-15 00:00:00
abstract::Concentrations of cholecystokinin-8 (CCK-8) and beta-endorphin (beta-EP) in T-lymphocytes of 26 women with bulimia nervosa (BN) and in 26 age- and sex-matched healthy comparison subjects were measured. Ten patients were then treated with 300 mg/day of fluvoxamine, p.o., and five patients were treated with 300 mg/day o...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(95)02674-6
更新日期:1995-11-29 00:00:00
abstract::Language disturbance has a central role in the presentation of psychotic disorders however its relationship with functioning requires further clarification, particularly in first episode psychosis (FEP). Both language disturbance and functioning can be evaluated with clinician-rated and performance-based measures. We ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2015.12.008
更新日期:2016-01-30 00:00:00
abstract::Functional magnetic resonance imaging was used to compare cortical activation patterns in healthy volunteers with those in patients with schizophrenia during a modified verbal Stroop task. Healthy subjects (n=13) and patients with schizophrenia (n=13) on stable antipsychotic treatment, matched on demographic variables...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0925-4927(03)00019-2
更新日期:2003-05-01 00:00:00
abstract::Faces are often used in psychological and neuroimaging research to assess perceptual and emotional processes. Most available stimulus sets, however, represent minimal diversity in both race and ethnicity, which may confound understanding of these processes in diverse/racially heterogeneous samples. Having a diverse st...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.04.066
更新日期:2018-12-01 00:00:00
abstract::Impairments in source monitoring have been widely reported in schizophrenia, with patients typically misattributing self-generated items to external sources. Some studies have reported that patients with more severe positive symptoms (notably hallucinations) exhibit a greater impairment on these tasks, although findin...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2007.02.018
更新日期:2008-06-30 00:00:00
abstract::This study assessed how well longitudinally taken cognitive and functional scales from people with mild cognitive impairment (MCI) predict conversion to Alzheimer's disease (AD). Participants were individuals with baseline MCI from the Alzheimer's Disease Neuroimaging Initiative. Scales included the Alzheimer Disease ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2020.113201
更新日期:2020-09-01 00:00:00
abstract::Lithium is an effective prophylactic agent in mood disorders, and genetic factors are likely to modulate individual susceptibility to lithium treatment. The aim of this study is to investigate the influence of dopamine receptor D2 (DRD2), D4 exon 3 (DRD4), and gamma-aminobutyric acid type A (GABA(A)) receptor alpha-1 ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(99)00056-6
更新日期:1999-07-30 00:00:00
abstract::In an attempt to assess the influence of standardized diagnostic interviews on psychological distress in research volunteers, the Visual Analogue Scale (VAS) was used to measure anxiety and depression during the Structured Clinical Interview for DSM-III-R, Non-patient version (SCID). Subjects were 50 adults with conce...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(95)02802-1
更新日期:1996-01-31 00:00:00
abstract::Obese people׳s distortions in visually-based mental body-parts representations have been reported in previous studies, but other sensory modalities have largely been neglected. In the present study, we investigated possible differences in tactilely-based body-parts representation between an obese and a healthy-weight ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2014.08.020
更新日期:2014-12-30 00:00:00
abstract::This study examined affective and psychological routes from childhood maltreatment to increased paranoia in adulthood. Recent anxiety and negative beliefs about the self partially accounted for the associations between emotional or physical abuse and paranoia. However, as full mediation did not occur, other psychologi...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2011.12.004
更新日期:2012-04-30 00:00:00
abstract::Dopamine agonists impair and antagonists normalize prepulse inhibition (PPI) of startle and gating of the P50 event-related potential (ERP), but the within-subject effect of treatment on impaired gating in schizophrenia has not been studied. We report the first results of a longitudinal study using PPI of ERPs as a me...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0925-4927(98)00053-5
更新日期:1999-02-22 00:00:00
abstract::This study reports on the naturalistic pharmacotherapy of 266 youths with bipolar disorder (BP), manic or hypomanic episode (158 males and 108 females, 13.8+/-2.8 years), first treated with monotherapy on valproic acid (VPA) (n=158, 59.4%), lithium (n=90, 33.8%) or atypical antipsychotics (n=18, 6.8%). Among the patie...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2009.01.022
更新日期:2010-05-15 00:00:00
abstract::Individuals with schizophrenia (SZ) and individuals with major depressive disorder (MDD) demonstrate impaired emotional memory and decreased enjoyment of pleasant experiences (e.g., anhedonia). However, it is unclear whether these impairments reflect similar or different processes in the two diagnostic groups. This st...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2015.09.012
更新日期:2015-12-15 00:00:00
abstract::The aim of our study was to investigate whether patients with obsessive-compulsive disorder (OCD) have impaired incidental memory for frequency. Fifty-four subjects (27 OCD patients and 27 matched control subjects) performed a task assessing estimation of occurrence of previously heard words. Performance on this task ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(01)00322-5
更新日期:2001-11-30 00:00:00
abstract::The current study examined whether there is a relationship between the dimension of delusion-proneness and performance on the color-word Stroop task. As dysfunction in the anterior cingulate cortex (ACC) has been related to both Stroop task performance and the presence of delusions in various psychiatric populations, ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2008.09.001
更新日期:2010-01-30 00:00:00
abstract::Regional brain activity was measured using quantitative electroencephalography (EEG) in six patients with obsessive-compulsive disorder (OCD) during live and imaginal exposure to feared contaminants. OCD symptoms increased significantly from baseline levels during live and imaginal exposures. However, live exposure pr...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(00)00177-3
更新日期:2000-08-21 00:00:00
abstract::Brain functional asymmetry abnormalities have previously been reported in schizophrenia. In the present study, we hypothesized that the pattern of functional asymmetry in schizophrenia may differ between patients suffering from positive and negative symptoms. We examined the relationship between altered asymmetry of f...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2009.11.004
更新日期:2010-04-30 00:00:00
abstract::Aerobic exercise (AE) has been shown to improve cognition in patients with schizophrenia. However, it remains unclear whether these exercise-induced cognitive benefits persist beyond the training period. Accordingly, the present study sought to examine the immediate and maintenance effects of AE on a wide range of cog...
journal_title:Psychiatry research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.psychres.2016.08.011
更新日期:2016-10-30 00:00:00
abstract::In the current cross-sectional study, we aimed to investigate the presence and severity of "male" depressive symptoms and suicidal behaviors in psychiatric patients with and without a history of child abuse and neglect, as measured by the Childhood Trauma Questionnaire (CTQ), as well as to explore the associations amo...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2014.07.056
更新日期:2014-12-15 00:00:00
abstract::Sodium lactate infusion provokes more physiological and psychological symptoms of panic in patients with panic attacks than in normal controls. The relationship between response to sodium lactate infusion and presenting clinical characteristics was examined in 50 patients with panic disorder or agoraphobia with panic ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(88)90096-0
更新日期:1988-09-01 00:00:00
abstract::This study assessed the perceived quality of life of individuals who were not in treatment for a psychiatric disorder and who were volunteers for a program to recruit control subjects. Subjects completed the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q) and a diagnostic evaluation for lifetime his...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2006.09.008
更新日期:2007-07-30 00:00:00
abstract::The neurotrophin, brain-derived neurotrophic factor (BDNF), characterises a probable neurobiochemical explanation of maldevelopments in schizophrenia and is a candidate biomarker of the illness. A paucity of studies examining neurobiochemical predictors of remission in schizophrenia exists. In this study, we seek to e...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2014.07.079
更新日期:2014-12-15 00:00:00
abstract::The level of personality functioning, relevant for treatment planning, can be evaluated by the Rorschach Comprehensive System (CS) Ego Impairment Index-2 (EII-2) and by interview assessment of the severity of personality pathology. However, few studies on the association between these assessment methods have been repo...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2012.05.012
更新日期:2012-12-30 00:00:00
abstract::Therapeutic interventions in chronic mental illness face the important challenge to pursuit the quality of life (QOL) of patients. Insight into chronic mental illness, though a prerequisite for treatment adherence and a positive therapeutic outcome, has shown adverse associations with subjective QOL. This study aims t...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2014.11.016
更新日期:2015-02-28 00:00:00
abstract::Personal space regulation is a key component of effective social engagement. Personal space varies among individuals and with some mental health conditions. Simulated personal space intrusions in Borderline Personality Disorder (BPD) reveal larger preferred interpersonal distance in that setting. These findings led us...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2017.11.054
更新日期:2018-02-01 00:00:00