Abstract:
:Concentrations of cholecystokinin-8 (CCK-8) and beta-endorphin (beta-EP) in T-lymphocytes of 26 women with bulimia nervosa (BN) and in 26 age- and sex-matched healthy comparison subjects were measured. Ten patients were then treated with 300 mg/day of fluvoxamine, p.o., and five patients were treated with 300 mg/day of amineptine, p.o., for 4 months. Concentrations of the two peptides were measured again after 1, 2, and 4 months of therapy. Basal CCK-8 values were significantly lower in patients than in healthy subjects. During fluvoxamine therapy, CCK-8 values increased, reaching normal levels by month 4 of treatment. No such increase occurred during amineptine therapy. Baseline beta-EP values were normal in the bulimic patients but had declined by month 4 of fluvoxamine therapy.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Brambilla F,Brunetta M,Draisci A,Peirone A,Perna G,Sacerdote P,Manfredi B,Panerai AEdoi
10.1016/0165-1781(95)02674-6subject
Has Abstractpub_date
1995-11-29 00:00:00pages
51-6issue
1-2eissn
0165-1781issn
1872-7123pii
0165-1781(95)02674-6journal_volume
59pub_type
杂志文章abstract::Major depressive disorder (MDD) had been associated with brain-derived neurotrophic factor (BDNF). Studies had shown that patients with MDD were associated with lower BDNF protein levels, which could be reversed by antidepressant treatment. BDNF expression had also been affected by a number of microRNAs (miRNA). BDNF ...
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