Abstract：
:Functional disconnectivity during the resting state has been observed in subjects with major depressive disorder (MDD), and in subjects at high genetic risk for major depression during task performance. It is hypothesized that functional impairments in certain brain areas are present in patients with MDD and in their first-degree relatives. To test this hypothesis, an analysis of regional homogeneity (ReHo) of the whole brain was performed on 45 subjects. Compared with the control group, subjects with MDD and those at high risk for MDD exhibited significantly decreased ReHo in the right insula and in the left cerebellum. These abnormalities may play an important role in the pathophysiology of depression.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Liu Z,Xu C,Xu Y,Wang Y,Zhao B,Lv Y,Cao X,Zhang K,Du Cdoi
10.1016/j.pscychresns.2010.03.004subject
Has Abstractpub_date
2010-06-30 00:00:00pages
211-5issue
3eissn
0165-1781issn
1872-7123pii
S0925-4927(10)00105-8journal_volume
182pub_type
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