Abstract：
:Overconfidence in false memories is often found in patients with schizophrenia and healthy participants with high levels of schizotypy, indicating an impairment of meta-cognition within the memory domain. In general, cognitive control is suggested to be modulated by natural fluctuations in oestrogen. However, whether oestrogen exerts beneficial effects on meta-memory has not yet been investigated. The present study sought to provide evidence that high levels of schizotypy are associated with increased false memory rates and overconfidence in false memories, and that these processes may be modulated by natural differences in estradiol levels. Using the Deese-Roediger-McDermott paradigm, it was found that highly schizotypal participants with high estradiol produced significantly fewer false memories than those with low estradiol. No such difference was found within the low schizotypy participants. Highly schizotypal participants with high estradiol were also less confident in their false memories than those with low estradiol; low schizotypy participants with high estradiol were more confident. However, these differences only approached significance. These findings suggest that the beneficial effect of estradiol on memory and meta-memory observed in healthy participants is specific to highly schizotypal individuals and might be related to individual differences in baseline dopaminergic activity.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Hodgetts S,Hausmann M,Weis Sdoi
10.1016/j.psychres.2015.08.016subject
Has Abstractpub_date
2015-10-30 00:00:00pages
708-14issue
3eissn
0165-1781issn
1872-7123pii
S0165-1781(15)30133-5journal_volume
229pub_type
杂志文章abstract：:In people with schizophrenia several factors are associated with poor quality of life (QoL), namely, lifestyle-related factors and psychological factors. However, there has been little research on the impact of these factors on QoL. Therefore, the relation between lifestyle-related factors, psychological factors, and ...
journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章
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pub_type： 临床试验,杂志文章
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更新日期：1990-08-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.07.054
更新日期：2012-12-30 00:00:00
