Abstract：
:Cognitive impairment is a frequent complication of advanced human immunodeficiency virus-1 (HIV-1) infection. However, structural imaging of the brain has not revealed abnormalities that precede the onset of clinical abnormalities. Cranial magnetic resonance (MR) studies were performed in 28 male subjects with intravenous drug use histories; nine were HIV-1 seronegative, 11 were HIV-1 seropositive but asymptomatic, and eight were seropositive and met symptomatic criteria for acquired immune deficiency syndrome (AIDS). Cortical atrophy, but not the degree of ventricular enlargement or signal abnormalities, was increased in the seropositive group compared with the seronegative group and also differed between asymptomatic seropositive and seronegative patients. An increased level of cortical atrophy may reflect the early impact of HIV-1 infection on the brain.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Handelsman L,Song IS,Losonczy M,Park S,Jacobson J,Wiener J,Aronson Mdoi
10.1016/0165-1781(93)90047-ksubject
Has Abstractpub_date
1993-05-01 00:00:00pages
175-86issue
2eissn
0165-1781issn
1872-7123pii
0165-1781(93)90047-Kjournal_volume
47pub_type
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