当前位置： SCI文献检索 > PSYCHIATRY RESEARCH期刊下所有文献 > Validation of the Investigator's Assessment Questionnaire, a new clinical tool for relative assessment of response to antipsychotics in patients with schizophrenia and schizoaffective disorder.

Validation of the Investigator's Assessment Questionnaire, a new clinical tool for relative assessment of response to antipsychotics in patients with schizophrenia and schizoaffective disorder.

Abstract：

:The success of long-term therapy in schizophrenia is contingent upon real-world effectiveness or improvements in several domains, including efficacy, safety and tolerability. This report describes the Investigator's Assessment Questionnaire (IAQ), a new 10-item instrument designed to assess relative effectiveness (efficacy, safety and tolerability) of antipsychotic medications in patients with schizophrenia or schizoaffective disorder. To measure content validity, 300 psychiatrists rated the importance of the IAQ items. Efficacy (i.e., positive and negative symptoms) was considered most important, but importance scores relative to the mean ranged only from 0.87 to 1.18, suggesting similar importance of the items. Cronbach's coefficient alpha values showed that the items were internally consistent. Factor analyses indicated that all IAQ items belong to a single domain. Data from the US Broad Effectiveness Trial of Aripiprazole were used for construct validation. Total IAQ score correlated significantly with time to treatment discontinuation (r=-0.50), Clinical Global Impressions-Improvement (CGI-I) score (r=0.76) and medication preference of patients (r=0.71) or caregivers (r=0.70). A one-unit decrease in IAQ score corresponded to an additional 1.35 days in the study and a decrease in CGI-I of 0.21 units. These results provide initial validation of the IAQ as a tool for evaluating antipsychotic response in patients with schizophrenia or schizoaffective disorder.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Tandon R,Devellis RF,Han J,Li H,Frangou S,Dursun S,Beuzen JN,Carson W,Corey-Lisle PK,Falissard B,Jody DN,Kujawa MJ,L'italien G,Marcus RN,McQuade RD,Ray S,Van Peborgh P,IAQ Validation Study Group.

doi

10.1016/j.psychres.2005.05.006

subject

Has Abstract

pub_date

2005-09-15 00:00:00

pages

211-21

issue

2-3

eissn

0165-1781

issn

1872-7123

pii

S0165-1781(05)00152-6

journal_volume

136

pub_type

杂志文章,多中心研究,随机对照试验

在线工具

Validation of the Investigator's Assessment Questionnaire, a new clinical tool for relative assessment of response to antipsychotics in patients with schizophrenia and schizoaffective disorder.