Abstract：
:Elderly stroke survivors are at risk of malnutrition and long-term cognitive impairment. Vitamin B-related metabolites, folate and methylmalonic acid, have been implicated in cognitive function. We conducted a study exploring the relationship between blood folate, methylmalonic acid and post-stroke cognitive impairment. This is a cross sectional study of elderly Swedish patients (n=149) 20 months post-stroke, assessed using the Mini Mental State Examination, serum blood levels of methylmalonic acid and red blood cell levels of folate. Linear modeling indicated that low levels of blood folate and elevated methylmalonic acid significantly contributed to cognitive impairment in stroke survivors. Half of the stroke survivors were shown to have folate deficiency at 20 months after stroke. Folate deficiency is common long term after stroke and both low folate and elevated methylmalonic acid appear to be associated with long term cognitive impairment, in elderly Swedish stroke survivors.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Pascoe MC,Linden Tdoi
10.1016/j.psychres.2016.06.008subject
Has Abstractpub_date
2016-09-30 00:00:00pages
49-52eissn
0165-1781issn
1872-7123pii
S0165-1781(15)30729-0journal_volume
243pub_type
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