Abstract：
:There is some evidence that sleep deprivation (SD) might exert its antidepressant properties by involving endogenous opioid mechanisms. The authors investigated the effects of mu-receptor agonist administration on prolactin release in depressed patients before and after partial SD. Medication-free female depressed inpatients (N=18) were participating in two fentanyl challenge tests after partial SD and undisturbed sleep, 3 days apart in random order. Healthy volunteer women (N=10) were enrolled after full night sleep as comparison subjects. Five of them had placebo trials. Participants were given an intravenous injection of 0.1 mg/70 kg fentanyl at 9:00 AM. The prolactin secretory response to the opiate agonist was investigated for 1 h with serial blood sampling. After a night of undisturbed sleep, fentanyl administration prompted increases in plasma prolactin concentrations with blunted responses found in the depressed group. Following partial SD, the stimulated prolactin secretion of depressed patients increased significantly and was comparable to the response of comparison subjects. These findings suggest that SD acts via an opioid/dopamine-related mechanism. An alternative explanation, based on serotonin involvement is addressed in the discussion.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Frecska E,Perenyi A,Arato Mdoi
10.1016/s0165-1781(03)00072-6subject
Has Abstractpub_date
2003-05-30 00:00:00pages
155-64issue
2eissn
0165-1781issn
1872-7123pii
S0165178103000726journal_volume
118pub_type
杂志文章abstract：:In a review of the current literature, we identified (1)H MRS studies of major depressive disorder (MDD) that examined the metabolites N-acetylaspartate (NAA), choline (Cho), myo-inositol (mI), glutamate/glutamine/gamma-aminobutyric acid-GABA (Glx), and creatine (Cr). Separate meta-analyses comparing adult and pediatr...
journal_title：Psychiatry research
pub_type： 杂志文章,meta分析
doi：10.1016/j.pscychresns.2005.12.004
更新日期：2006-06-30 00:00:00
abstract：:Language disturbance has a central role in the presentation of psychotic disorders however its relationship with functioning requires further clarification, particularly in first episode psychosis (FEP). Both language disturbance and functioning can be evaluated with clinician-rated and performance-based measures. We ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.12.008
更新日期：2016-01-30 00:00:00
abstract：:The astonishing 20 fold growth of the yearly published psychiatric research literature over the past four decades has been paralleled and facilitated by the internet application of electronic publishing. This personal history highlights the decade by decade 1978-2018 augmentation and erosion of this interelationship f...
journal_title：Psychiatry research
pub_type： 历史文章,杂志文章
doi：10.1016/j.psychres.2019.01.071
更新日期：2019-07-01 00:00:00
abstract：:Persons with schizophrenia and schizoaffective disorder exhibit deficits in both visual processing and neuropsychological tasks. Little is known, however, about whether these deficits are related to one another. We administered psychophysical tests of visual discrimination and recognition, and neuropsychological tests...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(02)00139-7
更新日期：2002-08-30 00:00:00
abstract：:Similar to members of the public, people with mental illness may exhibit general negative automatic prejudice against their own group. However, it is unclear whether more specific negative stereotypes are automatically activated among diagnosed individuals and how such automatic stereotyping may be related to self-rep...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.08.024
更新日期：2011-03-30 00:00:00
abstract：:Serum prolactin levels were monitored for 2 hours after injection of chlorpromazine (CPZ) 50 mg intramuscularly (i.m.) in 6 male normal controls and 14 newly admitted male chronic schizophrenics. The increase in serum prolactin levels in the male normal controls was not significantly different from that in patients. S...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(81)90065-2
更新日期：1981-08-01 00:00:00
abstract：:We developed a physical exercise intervention aimed at improving multiple determinants of physical performance in severe mental illness. A sample of 12 (9M, 3F) overweight or obese community-dwelling patients with schizophrenia (n=9) and bipolar disorder (n=3) completed an eight-week, high-velocity circuit resistance ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.07.007
更新日期：2015-09-30 00:00:00
abstract：:The limbic system plays an important role in regulating the hypothalamic-pituitary-adrenal (HPA) axis as well as aspects of emotion, and both neuroendocrine disturbance and increased negative emotionality are associated with risk for developing affective disorders. However, the extent to which the architecture of conn...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2011.07.015
更新日期：2012-01-30 00:00:00
abstract：:Several existing laboratory-based stress paradigms have significant shortcomings for assessing neurobiological correlates of stress in healthy volunteers and severely ill psychiatric patients. We have examined neuroendocrine effects of stress associated with the lumbar puncture (LP) procedure in drug-free depressed an...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(88)90050-9
更新日期：1988-08-01 00:00:00
abstract：:We aimed to assess the association between core cerebrospinal fluid (CSF) biomarkers, regional brain atrophy and clinical severity in the Alzheimer's disease (AD) continuum, as well as to investigate how cognitive reserve (CR) may modulate these putative associations. Forty-nine subjects (11 controls, 10 patients with...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2010.12.001
更新日期：2011-06-30 00:00:00
abstract：:Behavioral and biochemical studies in animals indicate that central dopaminergic neurotransmission may be modulated by sex steroids. This may be the mechanism underlying the suggested association between estrogen and schizophrenia. The aim was to examine if different levels of sex steroids during the menstrual cycle a...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(98)00021-3
更新日期：1998-07-15 00:00:00
abstract：:Previous research showed that lowering the availability of serotonin to the brain by tryptophan depletion increases the vulnerability of panic disorder patients for an experimental 35% CO(2) panic challenge. The results also suggested that increased availability of serotonin inhibits the response to such a challenge. ...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0165-1781(02)00262-7
更新日期：2002-12-30 00:00:00
abstract：:There is a growing recognition of the importance of encouraging patients with mental health problems to become more active as an efficacious strategy to reduce the disability-associated burden. The aim of the current study was to investigate if there are differences in quality of life (QoL) outcomes between people wit...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.08.041
更新日期：2017-12-01 00:00:00
abstract：:The Edinburgh High Risk Project is a longitudinal study of brain structure (and function) in subjects at high risk of developing schizophrenia in the next 5-10 years for genetic reasons. In this article we describe the methods of volumetric analysis of structural magnetic resonance images used in the study. We also co...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(99)00012-8
更新日期：1999-07-30 00:00:00
abstract：:Dopaminergic abnormalities in bulimia nervosa have been reported in some studies, but results are not consistent across studies. In the present study, clinical characteristics, plasma level of homovanillic acid (pHVA) and two scales - the Eating Attitudes Test (EAT) and the Beck Depression Inventory (BDI) - were asses...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.06.046
更新日期：2009-12-30 00:00:00
abstract：:Low plasma total testosterone (T) levels may influence the sense of well-being and produce depressive symptomatology, increasing the risk of suicide. In a previous study, we reported reduced serum T levels in male psychiatric patients after a suicide attempt. The reduction was more pronounced in subjects who used viol...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.08.001
更新日期：2009-11-30 00:00:00
abstract：:Deciding whether to disclose one's psychiatric disorder to a prospective employer is a complex decision for people with severe mental illness seeking to return to work, with potential advantages and disadvantages. The present study examined the rates, patterns, and correlates of disclosure in 51 participants (74.5% sc...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.01.017
更新日期：2019-03-01 00:00:00
abstract：:The antipsychotic effects of dopamine D2 receptor antagonists (neuroleptics) and the psychotomimetic effects of dopamine agonists suggest that a defect of the D2 receptor gene might be a factor in the etiology of schizophrenia. Fifteen families that contained several members suffering from schizophrenia were tested fo...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(94)90111-2
更新日期：1994-08-01 00:00:00
abstract：:Abnormalities of both the spontaneous and the stimulated release of growth hormone (GH) have been described in patients with endogenous depression. In this study, six unmedicated male patients with endogenous depression (ICD 296.1/3) were compared with six age-matched healthy men. Levels of GH were determined at 15-mi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(93)90080-z
更新日期：1993-06-01 00:00:00
abstract：:Implementation science has been recognized as a potential catalyst for health system reform, in part, because of its contribution of well-grounded conceptual theories, often encapsulated in frameworks. Well-designed frameworks provide a semantic structure, a common language by which to guide systematic approaches to s...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.psychres.2019.06.036
更新日期：2020-01-01 00:00:00
abstract：:Patients with schizophrenia show dysfunction in sustained attention and facial emotion processing. We investigated the interplay between sustained attention and emotion by presenting emotional faces as background during AX-CPT in patients with schizophrenia. Nineteen schizophrenia patients and 21 healthy control subje...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.11.007
更新日期：2011-05-15 00:00:00
abstract：PURPOSE:Since conduct problems (CP) vary distinctly across youths, better subtyping CP may be an important vehicle to study specific risk factors associated to differential patterns of CP. In a sample of 63,196 adolescents, we employed a two-step method to the identify such CP patterns and to help classify youths based...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113640
更新日期：2020-12-11 00:00:00
abstract：:A woman complained of feeling a "metal-like thing" in her oral cavity 4 years after a stroke. She was convinced of the physical nature of her complaint despite intact dental and neurological findings. Somatosensory evoked magnetic fields suggested that her decreased right SII function was compensated for by the right ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2005.10.003
更新日期：2006-01-30 00:00:00
abstract：:Brain functional asymmetry abnormalities have previously been reported in schizophrenia. In the present study, we hypothesized that the pattern of functional asymmetry in schizophrenia may differ between patients suffering from positive and negative symptoms. We examined the relationship between altered asymmetry of f...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2009.11.004
更新日期：2010-04-30 00:00:00
abstract：:Social functioning is an important component of mental disorders for assessment and treatment. There is no recognised self-report instrument to measure social functioning across disorders where social impairment is significant. The Social Functioning Scale (SFS) has, however, been used to assess social functioning in ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.03.037
更新日期：2019-06-01 00:00:00
abstract：:Dewan asserted 20 years ago that a bedside light could shorten and regularize the menstrual cycle among women with long and irregular menstrual patterns. To replicate this, seven volunteers slept with a 100-watt bulb by the bedside from days 13-17 of their menstrual cycles, while nine controls similarly used a dim red...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/0165-1781(90)90067-f
更新日期：1990-08-01 00:00:00
abstract：:This paper reports on a new family-centred, feedback-informed intervention focused on evaluating therapeutic outcomes and language changes across treatment for conduct disorder (CD). The study included 26 youth and families from a larger randomised, controlled trial (Ronan et al., in preparation). Outcome measures ref...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2016.11.035
更新日期：2017-05-01 00:00:00
abstract：:Specific patterns of cortical glucose metabolism disturbances and increased CSF phospho-tau (p-tau(181)) concentrations could be demonstrated to predict cognitive decline and shift to dementia in amnestic mild cognitive impairment (MCI). But comparisons of both diagnostic tools have not been undertaken so far. The aim...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2006.12.002
更新日期：2007-07-15 00:00:00
abstract：:A non-clinical sample of male Australian Vietnam veterans, their wives, and adult offspring were interviewed in-person in a national epidemiological study to assess the relationship between the mental ill-health of veterans and the emotional climate of the family while the children were growing up. Veterans were asses...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.06.071
更新日期：2018-10-01 00:00:00
abstract：:The study reported herein explored the comprehension of metaphor and irony in schizophrenia during remission, and examined the role of IQ and a theory of mind. Performance of 29 Schizophrenic patients in remission and 22 healthy controls was compared on metaphor and irony comprehension tasks and first- and second-orde...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.04.002
更新日期：2008-01-15 00:00:00
