Abstract：
:Specific patterns of cortical glucose metabolism disturbances and increased CSF phospho-tau (p-tau(181)) concentrations could be demonstrated to predict cognitive decline and shift to dementia in amnestic mild cognitive impairment (MCI). But comparisons of both diagnostic tools have not been undertaken so far. The aim of the study was to compare (18)F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) findings and CSF phospho-tau (p-tau(181)) measurements in the prediction of cognitive deterioration and conversion to dementia in MCI. During follow-up (mean 19 months) eight of 16 patients (50%) showed progressive cognitive decline, and four patients shifted to dementia. Pathological FDG-PET and elevated p-tau(181) levels both predicted deterioration. While p-tau(181) was highly sensitive for cognitive decline, FDG-PET was superior in predicting conversion to clinical dementia in MCI patients.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Fellgiebel A,Scheurich A,Bartenstein P,Müller MJdoi
10.1016/j.pscychresns.2006.12.002subject
Has Abstractpub_date
2007-07-15 00:00:00pages
167-71issue
2eissn
0165-1781issn
1872-7123pii
S0925-4927(06)00227-7journal_volume
155pub_type
杂志文章abstract：:Earlier (Bolinskey et al., 2015), we reported that psychometrically identified schizotypes displayed greater symptom levels and higher incidences of schizophrenia spectrum (schizotypal, schizoid, paranoid, and avoidant) personality disorders (PDs). In this study, 49 schizotypes and 39 matched controls participated in ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.03.014
更新日期：2017-06-01 00:00:00
abstract：:A notable number of young adults struggle to control impulsive behavior, resulting in impairment and distress. Assessments of problematic sexual behavior (PSB) have noted clinical differences relative to other populations, but neurocognitive findings have varied. This analysis assesses the clinical presentation and ne...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.09.044
更新日期：2016-12-30 00:00:00
abstract：:Autobiographical amnesia assessments in depression need to account for normal changes in consistency over time, contribution of mood and type of memories measured. We report herein validation studies of the Columbia Autobiographical Memory Interview - Short Form (CAMI-SF), exclusively used in depressed patients receiv...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2011.12.010
更新日期：2012-05-15 00:00:00
abstract：:Childhood adversities are key etiological factors in the onset and persistence of psychopathology. In Northern Ireland the Troubles also impacted on the population's psychological health. This study used data from the Northern Ireland Study of Health and Stress a collaborative epidemiological study which used the WMH-...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.02.024
更新日期：2018-04-01 00:00:00
abstract：:Past literature suggests that mental health literacy among the general public is lamentably poor. The study aimed to examine the effect of demographics, knowledge of psychology and psychiatry, and experience of mental illness as predictors for understanding and recognising personality disorders from vignette descripti...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2011.02.024
更新日期：2011-08-30 00:00:00
abstract：:Evidence shows that BDNF may regulate activity-dependent forms of synaptic plasticity underlying learning and memory. Previous studies reported low BDNF levels and cognitive impairment in the early stage of schizophrenia. Our current study aimed to explore the association between serum BDNF and cognitive functions in ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.02.034
更新日期：2018-05-01 00:00:00
abstract：:The aim of this study was to assess the association between anhedonia and metabolic syndrome (MetS) in a well-characterized community sample of individuals with a current depressive episode. This is a cross-sectional study with young adults aged 24-30 years old. Depressive episode and the presence of anhedonia was ass...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.08.009
更新日期：2019-01-01 00:00:00
abstract：:The relationship between sleep architecture and attentional performance was evaluated in neuroleptic-naive patients with schizophrenia and healthy controls. Participants were recorded in a sleep laboratory for two consecutive nights after which selective and sustained attention performance was tested. In both groups o...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2005.11.005
更新日期：2007-01-15 00:00:00
abstract：:Exposure to smoking cues increases craving to smoke and negatively changes mood in smokers with schizophrenia (SWS). This pilot study compared reactivity to real-world smoking environments versus neutral environments in SWS (n=10) and non-psychiatric control smokers (CON; n=10). Results indicate that both SWS and CON ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2011.04.005
更新日期：2011-07-30 00:00:00
abstract：:Specific phobias (SPs) are common, with lifetime prevalence estimates of 10%. Our current understanding of their pathophysiology owes much to neuroimaging studies, which enabled us to construct increasingly efficient models of the underlying neurocircuitry. We provide an updated, comprehensive review and analyze the r...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.pscychresns.2011.10.009
更新日期：2012-06-30 00:00:00
abstract：BACKGROUND:Several studies that have examined the full range of alcohol consumption have pointed to a possible non-linear association between alcohol use and the common mental disorders. Most of these studies are cross sectional and assessed psychiatric morbidity using non-specific instruments. Our aim was to investiga...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.05.049
更新日期：2016-09-30 00:00:00
abstract：:Intracranial volume (ICV) normalization of regional brain volumes (v) is common practice in volumetric studies of the aging brain. Multiple normalization methods exist and this study aimed to investigate when each method is appropriate to use in gender dimorphism studies and how differences in v are affected by the ch...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2014.11.011
更新日期：2015-03-30 00:00:00
abstract：:Many soldiers with mental illness (SWMIs) struggle with the decision whether to disclose their condition in or outside the military. This study therefore explored views on (self-)labeling as 'mentally ill', experiences of discrimination and coping, risks and benefits of (non-)disclosure, service use, disclosure decisi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.08.028
更新日期：2017-12-01 00:00:00
abstract：:Performance of the Wisconsin Card Sorting Test (WCST) and related brain-activation patterns reflect both task learning and execution. Normal subjects learned the WCST prior to performance during slow SPECT ligand infusion. Blood flow increased in bilateral inferior frontal, right middle and inferior parietal cortices....
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(98)00003-1
更新日期：1998-04-10 00:00:00
abstract：:Thirty depressed patients were compared with 39 controls for their plasma norepinephrine (NE) levels in relation to a cold challenge (placing a hand in ice cold water for 1 minute). Depressed patients showed significantly higher plasma NE levels than controls. Unipolar, but not bipolar patients, had significantly high...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(87)90073-4
更新日期：1987-06-01 00:00:00
abstract：:This study evaluated visual perceptual grouping in schizophrenia to test the hypothesis that the disorganization syndrome in schizophrenia is related to a deficit in cognitive coordination. Perceptual grouping was examined with three psychophysically well-controlled tasks in patients with disorganized schizophrenia (n...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2005.10.016
更新日期：2006-12-07 00:00:00
abstract：:There is little evidence on the association between area-level social factors and schizophrenia in China. This study aimed to investigate the relationship between county-level social factors and schizophrenia in Chinese adults aged 18 years old and above. We obtained data from the Second China National Sample Survey o...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.08.057
更新日期：2019-01-01 00:00:00
abstract：:Platelet monoamine oxidase (MAO) activity and intellectual level were examined in a large series of 1,129 18-year-old boys, selected from the general population. Personality traits were determined by means of selected subscales from several personality inventories such as the Zuckerman Sensation Seeking Scale, the Eys...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(84)90134-3
更新日期：1984-05-01 00:00:00
abstract：:Major depressive disorder is associated with lower medial prefrontal cortex volumes. The role that gender might play in moderating this relationship and what particular medial prefrontal cortex subregion(s) might be implicated is unclear. Magnetic resonance imaging was used to assess dorsal, ventral, and anterior cing...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2015.06.005
更新日期：2015-08-30 00:00:00
abstract：:The etiopathogenesis of eating disorders (EDs) is complex and still not well understood. Biological, psychological and environmental factors (e.g. childhood abuse) have all been considered to be involved in the onset and the persistence of EDs. The hypothalamic-pituitary-adrenal (HPA) axis is a relevant biological fac...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.03.046
更新日期：2019-05-01 00:00:00
abstract：:Previous research indicates that interactions between FKBP5 single nucleotide polymorphisms (SNPs) and child abuse are associated with posttraumatic stress disorder (PTSD) in adulthood. We examined the relationship between the T-allele of the rs1360780 FKBP5 SNP and child abuse on PTSD and the HPA axis in a clinical s...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.03.037
更新日期：2018-12-01 00:00:00
abstract：:The jumping to conclusions bias (JTC), in which some people gather less information than others before making a decision, has been linked to delusions in psychosis. JTC is usually identified via the beads task, in which a sequence of beads (the "target" sequence) is used to measure the amount of evidence participants ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.04.043
更新日期：2018-07-01 00:00:00
abstract：:The goal of this study was to investigate gambling-related behavior, onset and progression in a sample of at-risk gamblers from the community. A national household survey was conducted in Brazil, covering individuals 14 years old or older. Subjects were screened for at-risk gambling, those testing positive answered a ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.01.035
更新日期：2014-05-30 00:00:00
abstract：:Childhood adversity is associated with a range of mental disorders, functional impairment and higher health care costs in adulthood. In this study we evaluated if childhood adversity was predictive of adverse clinical and functional outcomes and health care costs in a sample of patients at ultra-high risk (UHR) for de...
journal_title：Psychiatry research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.psychres.2016.11.014
更新日期：2017-01-01 00:00:00
abstract：:The aim of this study was to develop self-report and clinician-rated versions of an insight scale that would be easy to administer, sensitive to small changes, and inclusive of the core dimensions of clinical insight into psychosis. Ten-item self-report (VAGUS-SR) and five-item clinician-rated (VAGUS-CR) scales were d...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.08.005
更新日期：2014-12-30 00:00:00
abstract：:Several diffusion tensor imaging (DTI) studies have reported disturbed white matter integrity in various brain regions in patients with schizophrenia, whereas only a few studied the effect of antipsychotics on DTI measures. The aim of this study was to investigate the effect of 12 weeks of clozapine treatment on DTI f...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2014.06.001
更新日期：2014-09-30 00:00:00
abstract：:Previous research suggests that people with schizophrenia have difficulty learning from positive feedback and when learning needs to occur rapidly. However, they seem to have relatively intact learning from negative feedback when learning occurs gradually. Participants are typically given a limited amount of acquisiti...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.08.013
更新日期：2014-12-30 00:00:00
abstract：:Panic disorder (PD) is characterized by anticipatory anxiety and panic, both causing physiological arousal. We investigated the differential responses between anticipatory anxiety and panic in PD and healthy controls (HC). Subjects (15 PD and 30 HC) received an injection of a respiratory stimulant, doxapram, with a hi...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2015.03.001
更新日期：2015-05-30 00:00:00
abstract：:If dissociative symptoms are manifestations of a psychological defense mechanism, one would expect people who have such symptoms to react with lower levels of physiological arousal and with memory omissions to emotionally provocative material. The current study tested this assumption in a sample of undergraduates. Six...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.04.016
更新日期：2007-04-15 00:00:00
abstract：:Our main purpose was to investigate how smoking and nicotine interacted with specific aspects of cognitive functioning. The research was conducted in two parts: (i) an investigation of cognition in heavy smokers and healthy nonsmokers, and (ii) an investigation of cognition in healthy nonsmokers enrolled in a clinical...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113357
更新日期：2020-11-01 00:00:00
