Abstract：
:This study evaluated visual perceptual grouping in schizophrenia to test the hypothesis that the disorganization syndrome in schizophrenia is related to a deficit in cognitive coordination. Perceptual grouping was examined with three psychophysically well-controlled tasks in patients with disorganized schizophrenia (n=11), non-disorganized schizophrenia (n=24), psychotic disorders other than schizophrenia (n=31) and non-psychotic psychiatric disorders (n=35). These measures assessed processing of both concurrent and preceding stimulus context. Deficits in perceptual grouping were observed on all three tasks in disorganized schizophrenia patients. Dysfunctional perceptual grouping mechanisms produced both enhanced and impaired task performance suggesting that the pattern of performance observed was the result of a specific deficit in the grouping of stimulus elements. We interpret these data as further support for the hypothesis that the disorganization syndrome in schizophrenia reflects a widespread deficit in the cognitive coordination of contextually related stimuli, leading to dysfunctional grouping of stimulus features in vision, thought and language.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Uhlhaas PJ,Phillips WA,Mitchell G,Silverstein SMdoi
10.1016/j.psychres.2005.10.016subject
Has Abstractpub_date
2006-12-07 00:00:00pages
105-17issue
2-3eissn
0165-1781issn
1872-7123pii
S0165-1781(05)00417-8journal_volume
145pub_type
杂志文章abstract：:Patients with schizophrenia exhibit reduced levels of both prepulse inhibition of the startle reflex (PPI) and condition-test suppression of the P50 event-related potential. This study investigated the extent to which PPI and P50 suppression, which exhibit similar parametric sensitivities, are intrinsically auditory p...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2005.11.002
更新日期：2006-08-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0925-4927(96)02790-4
更新日期：1996-10-07 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.08.028
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：1987-05-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章,meta分析
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更新日期：2016-01-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2012-06-30 00:00:00
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journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
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更新日期：1986-07-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.05.016
更新日期：2014-10-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2004.07.001
更新日期：2004-11-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.11.017
更新日期：2015-01-30 00:00:00
abstract：:Pediatric Bipolar Disorder (PBD) is a highly heritable condition responsible for 18% of all pediatric mental health hospitalizations. Despite the heritability of this disorder, few studies have assessed potential differences in the clinical manifestation of PBD among patients with a clear parental history of BD. Addit...
journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2019-10-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章,meta分析
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更新日期：2020-02-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.06.028
更新日期：2013-12-15 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.08.052
更新日期：2016-11-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.07.002
更新日期：2017-10-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.05.017
更新日期：2017-09-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.07.028
更新日期：2017-11-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(92)90020-4
更新日期：1992-01-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章,评审
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更新日期：2019-07-01 00:00:00
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journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
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更新日期：1990-05-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2020-02-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.01.023
更新日期：2013-10-30 00:00:00
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journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/j.psychres.2005.12.009
更新日期：2007-01-15 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.05.089
更新日期：2015-08-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.11.035
更新日期：2015-02-28 00:00:00
abstract：:Adolescent offspring of schizophrenia patients (SCZ-Off) are vulnerable to psychiatric disorders. Assessing relationships between clinical and biological measures (such as functional magnetic resonance imaging, fMRI) may elucidate pathways of vulnerability in this group. Here we assessed the relationship between clini...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2010.12.005
更新日期：2011-05-31 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2011.10.008
更新日期：2012-03-30 00:00:00
abstract：:The aim of the study was to describe diagnostic stability and psychosocial outcomes of subjects with early-onset schizophrenia (EOS). All the subjects who had been hospitalized in the Department of Psychiatry of the First Affiliated Hospital of Kunming Medical University between January 2011 and July 2015 with the dia...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.11.013
更新日期：2019-01-01 00:00:00
abstract：:The activity of phosphatidylinositol-specific phospholipase C was significantly reduced in platelets obtained from 20 euthymic manic-depressive patients on therapeutic lithium doses (mean blood level 0.85 mEq/l) compared to an age- and sex-matched group of 36 control subjects. The activities of prostaglandin E1-, alum...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(88)90138-2
更新日期：1988-04-01 00:00:00
