Abstract：
:This study evaluated visual perceptual grouping in schizophrenia to test the hypothesis that the disorganization syndrome in schizophrenia is related to a deficit in cognitive coordination. Perceptual grouping was examined with three psychophysically well-controlled tasks in patients with disorganized schizophrenia (n=11), non-disorganized schizophrenia (n=24), psychotic disorders other than schizophrenia (n=31) and non-psychotic psychiatric disorders (n=35). These measures assessed processing of both concurrent and preceding stimulus context. Deficits in perceptual grouping were observed on all three tasks in disorganized schizophrenia patients. Dysfunctional perceptual grouping mechanisms produced both enhanced and impaired task performance suggesting that the pattern of performance observed was the result of a specific deficit in the grouping of stimulus elements. We interpret these data as further support for the hypothesis that the disorganization syndrome in schizophrenia reflects a widespread deficit in the cognitive coordination of contextually related stimuli, leading to dysfunctional grouping of stimulus features in vision, thought and language.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Uhlhaas PJ,Phillips WA,Mitchell G,Silverstein SMdoi
10.1016/j.psychres.2005.10.016subject
Has Abstractpub_date
2006-12-07 00:00:00pages
105-17issue
2-3eissn
0165-1781issn
1872-7123pii
S0165-1781(05)00417-8journal_volume
145pub_type
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