Abstract:
:This study compared basal concentrations of plasma beta-endorphin/beta-lipotropin-like immunoreactivity and dexamethasone suppression of cortisol in seven chronic pain patients, seven psychiatric disorder patients, and seven normal volunteers. Pain patients and psychiatric patients showed significantly higher basal concentrations of beta-endorphin/beta-lipotropin-like immunoreactivity compared to normal volunteers. Pain patients also had significantly higher beta-endorphin/beta-lipotropin-like immunoreactivity than psychiatric patients, even though there was no significant difference in severity of depressive symptomatology as assessed by Beck and Hamilton scores. Resistance to dexamethasone occurred in 57% of pain patients. These results may indicate that biological markers for depression occur in populations of chronic pain patients, or may reflect levels of central nervous system arousal in response to stress, pain, or nonaffective phenomena.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Atkinson JH,Kremer EF,Risch SC,Morgan CD,Azad RF,Ehlers CL,Bloom FEdoi
10.1016/0165-1781(83)90005-7subject
Has Abstractpub_date
1983-08-01 00:00:00pages
319-27issue
4eissn
0165-1781issn
1872-7123pii
0165-1781(83)90005-7journal_volume
9pub_type
杂志文章abstract::The success of long-term therapy in schizophrenia is contingent upon real-world effectiveness or improvements in several domains, including efficacy, safety and tolerability. This report describes the Investigator's Assessment Questionnaire (IAQ), a new 10-item instrument designed to assess relative effectiveness (eff...
journal_title:Psychiatry research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.psychres.2005.05.006
更新日期:2005-09-15 00:00:00
abstract::Posttraumatic stress disorder (PTSD) and social anxiety disorder (SAD) are highly comorbid (Collimore et al., 2010). Trauma may present a shared environmental factor contributing to the development of comorbidity; however, existent research has been hampered by use of restrictive samples and limitations in the range o...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.10.036
更新日期:2016-12-30 00:00:00
abstract::The tryptophan catabolite (TRYCAT) pathway is induced by indoleamine 2,3-dioxygenase (IDO), which upon activation depletes plasma tryptophan (TRP) and increases the synthesis of TRYCATs. Both phenomena are associated with somatization and depression. The aims of this study are to examine whether disorders in the TRYCA...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2011.09.029
更新日期:2012-04-30 00:00:00
abstract::Previous research suggests that people with schizophrenia have difficulty learning from positive feedback and when learning needs to occur rapidly. However, they seem to have relatively intact learning from negative feedback when learning occurs gradually. Participants are typically given a limited amount of acquisiti...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2014.08.013
更新日期:2014-12-30 00:00:00
abstract::Six patients with bipolar II seasonal affective disorder (SAD) and seven normal control subjects rated their moods in winter at six fixed times each week-day during 1 week of dim and 2 weeks of bright light. The scales rated represent the mood dimension specifically associated with depression, a dimension here called ...
journal_title:Psychiatry research
pub_type: 临床试验,杂志文章
doi:10.1016/0165-1781(92)90129-q
更新日期:1992-08-01 00:00:00
abstract::Because estrogen may influence brain blood flow and metabolism in older adults, we used positron emission tomography to evaluate cerebral glucose metabolic change in post-menopausal women and men. Women estrogen users (n=4), women non-users (n=8) and men (n=10) were scanned at baseline and two years later. Analyses fo...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0925-4927(01)00084-1
更新日期:2001-07-01 00:00:00
abstract::At the beginning of the 2020 New year, novel coronavirus infection continues to affect our lives. The anxiety and stress caused by rising epidemic data, the helplessness and fear caused by city closure and isolation, and the boredom and irritability caused by extended holiday grounding all have a great impact on the p...
journal_title:Psychiatry research
pub_type: 杂志文章,评审
doi:10.1016/j.psychres.2020.113043
更新日期:2020-04-29 00:00:00
abstract::Evidence shows that BDNF may regulate activity-dependent forms of synaptic plasticity underlying learning and memory. Previous studies reported low BDNF levels and cognitive impairment in the early stage of schizophrenia. Our current study aimed to explore the association between serum BDNF and cognitive functions in ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.02.034
更新日期:2018-05-01 00:00:00
abstract::The Delirium Motor Subtype Scale (DMSS) was developed by discerning the best differentiating motor activity symptoms from the Delirium Motor Checklist (DMC), a compilation of psychomotor symptoms from other subjective scales. To broaden its validation we replicated the original work done in a palliative care populatio...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2012.08.034
更新日期:2013-03-30 00:00:00
abstract::Although several studies have detected differences in clinical features among specific phobias, there is a shortage of detailed national data on the on the DSM-IV SP subtypes, particularly in the Asian population. To examine the prevalence, demographic and other correlates, and co-morbidities of DSM-IV SP subtypes in ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2012.12.025
更新日期:2013-10-30 00:00:00
abstract::This study tested the hypothesis that adverse events are associated with increased risk of onset of anxiety disorders. Data from Waves 1 (N = 43,093; 2001-2002) and 2 (N = 34,653; 2004-2005) of the National Epidemiological Survey on Alcohol and Related Conditions (NESARC) were used to assess whether adverse events at ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2017.11.027
更新日期:2018-01-01 00:00:00
abstract::Research on the sub-clinical condition of schizotypy suggests that it is associated with mixed handedness. To date, however, this research has focussed on undergraduate populations. If the association between schizotypy and mixed-handedness is the result of an underlying neurological trait, it is important to demonstr...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2010.11.019
更新日期:2011-05-15 00:00:00
abstract::No prospective studies of first psychotic episodes have explored sex differences in smoking cessation. The aim of this study was to determine the influence of sex and substance abuse on smoking cessation during an 8-year follow-up of patients after a first psychotic episode. Logistic regression modeling was used to id...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2011.08.005
更新日期:2012-01-30 00:00:00
abstract::Hoarding is linked to ambivalence and uncertainty about one's self and others. These notions are close to those constituting attachment representations. Hoarding is also linked to seeking support from objects. Studies concerning attachment and hoarding suggest that attachment representations may impact seeking or poss...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.09.053
更新日期:2018-12-01 00:00:00
abstract::We report the results of a high-density attempted suicide association study of the X chromosome, which genotyped 23,141 SNPs on 983 attempters and 1143 non-attempters and generated modest evidence for association for SH3KBP1 (P=1.07×10(-4)) and GRIA3 (P=4.01×10(-4)). These findings highlight the need for larger sample...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2012.06.001
更新日期:2012-12-30 00:00:00
abstract::Patients with borderline personality disorder (BPD) suffer from various impairments in emotional functioning such as affective instability, inappropriate anger and unstable relationships. These deficits may influence two fundamental motivational systems, the behavioral inhibition system (BIS) and behavioral activation...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2014.04.027
更新日期:2014-08-15 00:00:00
abstract::Theory of Mind (ToM) is the ability to correctly determine the intentions and behaviours of others. It is known that this capability is compromised in individuals with schizophrenia. It is has not been fully elucidated whether this observed phenomenon is of a state or trait nature. This study investigated whether ToM ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2006.01.008
更新日期:2006-09-30 00:00:00
abstract::High variability in adaptive behavior in cognitively-able adults with autism spectrum disorder has been previously reported, and may be caused by the high prevalence of psychiatric comorbidity in this population. This study's goals were to examine self-reported psychiatric symptoms in students with ASD, and to identif...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2019.01.098
更新日期:2019-03-01 00:00:00
abstract::The pathophysiology of pediatric bipolar disorder (PBD) impacts both affective and cognitive brain systems. Understanding disturbances in the neural circuits subserving these abilities is critical for characterizing developmental aberrations associated with the disorder and developing improved treatments. Our objectiv...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2007.10.003
更新日期:2008-04-15 00:00:00
abstract::Studies using a variety of investigative methods, including functional brain imaging and electroencephalography (EEG), have suggested that changes in central nervous system (CNS) dopamine function result in altered visual system processing. The discovery of abnormal retinal blue cone, but not red cone, electroretinogr...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0925-4927(00)00074-3
更新日期:2000-12-22 00:00:00
abstract::The medial temporal cortex (MTC) has been implicated in the pathogenesis of pediatric major depressive disorder (MDD). Eleven MDD case-control pairs underwent proton magnetic resonance spectroscopic imaging. N-acetyl-aspartate was lower in the left MTC (27%) in MDD patients versus controls. Lower N-acetyl-aspartate co...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2007.12.022
更新日期:2008-10-30 00:00:00
abstract::To evaluate the effects of ethanol in the human brain, we tested six normal subjects and six alcoholics using positron emission tomography and 2-deoxy-2-[18F]-fluoro-D-glucose (FDG) under baseline conditions and 24 hours later after ethanol administration (1 g/kg). Ethanol inhibited cortical and cerebellar glucose met...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0925-4927(90)90007-s
更新日期:1990-04-01 00:00:00
abstract::Longitudinal cohort studies have implicated an association between both low and high birth weight and schizophrenia. It has been suggested that schizophrenia associated genes could augment an individual's susceptibility to adverse prenatal and perinatal environmental events. We investigated the association between bir...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2011.05.035
更新日期:2011-12-30 00:00:00
abstract::We investigated platelet 14C-serotonin uptake and platelet [3H]LSD and [3H]paroxetine binding in 11 patients with seasonal affective disorder (SAD). Patients were reinvestigated after light therapy, applied at 07.00-09.00 h for 10 consecutive days. The degree of depression was rated before and after light therapy usin...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(98)00017-1
更新日期:1998-05-08 00:00:00
abstract::Platelet monoamine oxidase (MAO) activity and intellectual level were examined in a large series of 1,129 18-year-old boys, selected from the general population. Personality traits were determined by means of selected subscales from several personality inventories such as the Zuckerman Sensation Seeking Scale, the Eys...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(84)90134-3
更新日期:1984-05-01 00:00:00
abstract::The relationship between personality, as measured by selected clinical scales of the Minnesota Multiphasic Personality Inventory (MMPI) (Hypochondriasis, Depression, Hysteria, Psychasthenia, Social Introversion, and Anxiety) and the Anxiety Sensitivity Index (ASI), and behavioral response to the panicogenic agent chol...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(96)02819-3
更新日期:1996-05-17 00:00:00
abstract::Many young adults who attempt suicide have no discernible mental illness, suggesting an etiology distinct from other psychiatric disorders. Neurological anomalies associated with a history of suicidal behavior may predict future risk. In the present study, we explored changes in neural circuit organization associated ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2014.10.011
更新日期:2015-02-28 00:00:00
abstract::Genotype frequencies of functional polymorphisms in the genes encoding the serotonin transporter (5-HTT) and the enzyme catechol-O-methyltransferase (COMT) were not different in 51 suicidal inpatients compared to 51 control subjects. Within the patient group, increased hopelessness and suicide ideation were associated...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(00)00128-1
更新日期:2000-02-14 00:00:00
abstract::The association of seven GDNF tag SNPs with depression, heroin dependence (HD) and schizophrenia was evaluated in Chinese. An increased risk of HD and depression was associated with rs2910709 T/T genotype and rs884344 C allele, respectively, suggesting GDNF is a novel susceptibility gene for depression and HD. ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2013.08.025
更新日期:2013-12-30 00:00:00
abstract::Ten long-term abstinent alcoholics (mean abstinence = 7.7 years) were compared with 13 recently detoxified substance-dependent inpatients (mean abstinence = 25 days) and 8 nonalcoholic control subjects on global end regional measures of cortical cerebral blood flow (CBF), and on neuropsychological measures. CBF was as...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0925-4927(96)02769-2
更新日期:1996-07-31 00:00:00