Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.

Abstract:

:Previous research showed that lowering the availability of serotonin to the brain by tryptophan depletion increases the vulnerability of panic disorder patients for an experimental 35% CO(2) panic challenge. The results also suggested that increased availability of serotonin inhibits the response to such a challenge. In the present study, this latter possibility is examined. The reaction of 24 panic disorder patients and 24 healthy volunteers to a 35% CO(2) panic challenge was assessed following administration of 200-mg L-5-hydroxytryptophan (the immediate precursor of serotonin) or placebo. L-5-Hydroxytryptophan significantly reduced the reaction to the panic challenge in panic disorder patients, regarding subjective anxiety, panic symptom score and number of panic attacks, as opposed to placebo. No such effect was observed in the healthy volunteers. L-5-Hydroxytryptophan acts to inhibit panic, which supports a modulatory role of serotonin in panic disorder.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Schruers K,van Diest R,Overbeek T,Griez E

doi

10.1016/s0165-1781(02)00262-7

subject

Has Abstract

pub_date

2002-12-30 00:00:00

pages

237-43

issue

3

eissn

0165-1781

issn

1872-7123

pii

S0165178102002627

journal_volume

113

pub_type

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