Abstract:
:Previous research showed that lowering the availability of serotonin to the brain by tryptophan depletion increases the vulnerability of panic disorder patients for an experimental 35% CO(2) panic challenge. The results also suggested that increased availability of serotonin inhibits the response to such a challenge. In the present study, this latter possibility is examined. The reaction of 24 panic disorder patients and 24 healthy volunteers to a 35% CO(2) panic challenge was assessed following administration of 200-mg L-5-hydroxytryptophan (the immediate precursor of serotonin) or placebo. L-5-Hydroxytryptophan significantly reduced the reaction to the panic challenge in panic disorder patients, regarding subjective anxiety, panic symptom score and number of panic attacks, as opposed to placebo. No such effect was observed in the healthy volunteers. L-5-Hydroxytryptophan acts to inhibit panic, which supports a modulatory role of serotonin in panic disorder.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Schruers K,van Diest R,Overbeek T,Griez Edoi
10.1016/s0165-1781(02)00262-7subject
Has Abstractpub_date
2002-12-30 00:00:00pages
237-43issue
3eissn
0165-1781issn
1872-7123pii
S0165178102002627journal_volume
113pub_type
临床试验,杂志文章,随机对照试验abstract::The present study utilized factor analysis to investigate possible underlying processes in schizophrenic thought disorder. Using the Communication Disturbances Index [CDI; Arch. Gen. Psychiatry, 53, (1996) 358], a measure of disruption in the communication of meaning from speaker to listener, we examined the speech of...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(00)00239-0
更新日期:2001-02-14 00:00:00
abstract::Active uptake of serotonin (5-hydroxytryptamine, 5-HT) by blood platelets of acute and chronic schizophrenic patients was compared with that of normal controls. Unlike previous reports, no significant difference in the kinetic parameters (Km and Vmax) of 5-HT uptake between schizophrenic patients and normal controls w...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(82)90022-1
更新日期:1982-06-01 00:00:00
abstract::Most people with a serious mental illness experience significant functional impairment despite ongoing pharmacological treatment. Thus, in order to improve outcomes, a better understanding of functional predictors is needed. This study examined negative affect, a construct comprised of negative emotional experience, a...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.06.031
更新日期:2016-09-30 00:00:00
abstract::The success of long-term therapy in schizophrenia is contingent upon real-world effectiveness or improvements in several domains, including efficacy, safety and tolerability. This report describes the Investigator's Assessment Questionnaire (IAQ), a new 10-item instrument designed to assess relative effectiveness (eff...
journal_title:Psychiatry research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.psychres.2005.05.006
更新日期:2005-09-15 00:00:00
abstract::Schizophrenia has been associated with autonomic dysregulation and increased cardiovascular co-morbidity. We hypothesised that autonomic dysregulation in patients with schizophrenia is associated with psychopathology and metabolic profiles. In this study, we aimed to evaluate psychopathology, comprehensive metabolic p...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2013.07.034
更新日期:2013-12-30 00:00:00
abstract::Several diffusion tensor imaging (DTI) studies have reported disturbed white matter integrity in various brain regions in patients with schizophrenia, whereas only a few studied the effect of antipsychotics on DTI measures. The aim of this study was to investigate the effect of 12 weeks of clozapine treatment on DTI f...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2014.06.001
更新日期:2014-09-30 00:00:00
abstract::The significance of neurological signs in schizophrenia is poorly understood. In part, this may reflect the marked variability in the methods of ascertainment in previous studies. The Neurological Evaluation Scale (NES) is designed to standardize the assessment of neurological impairment in schizophrenia. The battery ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(89)90148-0
更新日期:1989-03-01 00:00:00
abstract::We explored the possibility of diagnostic confusion between hypersomnias of central origin (narcolepsy and idiopathic hypersomnia, IH) and the adult form of attention-deficit/hyperactivity disorder (ADHD). We included 67 patients with narcolepsy, 7 with IH and 61 with ADHD. All patients completed the Epworth Sleepines...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2006.02.009
更新日期:2006-08-30 00:00:00
abstract::Modest alcohol and aggressive trait effects on laboratory-induced aggression among men have been reported with some consistency in the literature. Relationships between aggressive personality traits and laboratory-induced aggression appear to become less consistent under the influence of alcohol. Several research team...
journal_title:Psychiatry research
pub_type: 杂志文章,评审
doi:10.1016/j.psychres.2005.10.015
更新日期:2006-06-15 00:00:00
abstract::Patients with a first episode of schizophrenia generally have increased phospholipid membrane breakdown products within the brain, while findings in chronic patients have been inconsistent. In this study we examine progressive changes in phosphorus membrane metabolites in the same patient group through the early years...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2011.06.017
更新日期:2012-01-30 00:00:00
abstract::A variety of studies were addressed to differentiate responders and non-responders to substitution treatment among heroin dependent patients, without conclusive findings. In particular, preliminary pharmacogenetic findings have been reported to predict treatment effectiveness in mental health and substance use disorde...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2013.11.001
更新日期:2014-01-30 00:00:00
abstract::Depressive symptoms are common in children and adolescents. The prevalence of depressive symptoms in children and adolescents in China vary significantly across studies. A meta-analysis of the prevalence of depressive symptoms in children and adolescents in China was conducted. Literature search was performed in both ...
journal_title:Psychiatry research
pub_type: 杂志文章,meta分析
doi:10.1016/j.psychres.2018.12.133
更新日期:2019-02-01 00:00:00
abstract::Previous studies suggest that insulin-sensitizing agents could play a significant role in the treatment of major depression, particularly depression in patients with documented insulin resistance or those who are resistant to standard psychopharmacological approaches. This study aimed to assess the effects on depressi...
journal_title:Psychiatry research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psychres.2015.10.013
更新日期:2015-12-30 00:00:00
abstract::Posttraumatic stress disorder (PTSD) is an anxiety- and memory-based disorder. The hippocampus and amygdala are key areas in mood regulation. Fluoxetine was found to improve the anxiety-related symptoms of PTSD patients. However, little work has directly examined the effects of fluoxetine on the hippocampus and the am...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2015.02.011
更新日期:2015-05-30 00:00:00
abstract::Destination memory refers to the ability to remember to whom a piece of information was previously transmitted. Our paper assessed this ability in schizophrenia. Twenty-five patients with schizophrenia and 25 control participants told proverbs (e.g., "send a thief to catch a thief") to pictures of celebrities (e.g., E...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.12.023
更新日期:2017-02-01 00:00:00
abstract::Although the fear of being scrutinized by others in a social context is a key symptom in social anxiety disorder (SAD), the neural processes underlying the perception of scrutiny have not previously been studied by functional magnetic resonance imaging (fMRI). We used fMRI to map brain activation during a perception-o...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2011.10.008
更新日期:2012-06-30 00:00:00
abstract::Five women with primary major bipolar affective disorders had variable and at times very high urinary phenylethylamine (PEA) excretion rates. The clinical picture of these patients was characterized by periodic bizarre behaviors and short psychotic episodes. These patients were generally nonresponsive to the usual tre...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(82)90009-9
更新日期:1982-04-01 00:00:00
abstract::Human immunodeficiency virus (HIV) infection and methamphetamine (MA) dependence are associated with neural injury preferentially involving frontostriatal circuits. Little is known, however, about how these commonly comorbid conditions impact behavioral presentations typically associated with frontal systems dysfuncti...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2013.11.004
更新日期:2014-01-30 00:00:00
abstract::In recent years, there has been increased interest in a clinical syndrome characterized by excessive sexual thoughts, sexual urges, and/or sexual behaviors that has many aspects in common with impulse control disorders. This study provides a preliminary examination of the impulsive aspects of this syndrome, compulsive...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2009.04.008
更新日期:2009-11-30 00:00:00
abstract::The Morningness-Eveningness Questionnaire (MEQ) is among the most commonly used scales to measure chronotype. We aimed to evaluate psychometric properties and clinical correlates of MEQ in bipolar disorder. Patients with a clinical diagnosis of bipolar disorder (n = 53) answered questionnaires for chronotype (MEQ), mo...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.02.004
更新日期:2018-04-01 00:00:00
abstract::Considerable disagreement exists about the neuroanatomical basis of conceptual-semantic impairments observed in a subgroup of patients with Alzheimer's disease (AD) at mild to moderate stages of the disease. Several studies of groups of patients have shown correlations between focal hypometabolism or hypoperfusion in ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2004.07.006
更新日期:2004-12-15 00:00:00
abstract::Simple reaction time (SRT) was measured in schizophrenic, bipolar affective disorder, and never-psychotic outpatients to determine the specificity of SRT crossover to schizophrenia. A crossover pattern like that reported in other studies was found among the schizophrenics, but the average curve was not different from ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(83)90084-7
更新日期:1983-05-01 00:00:00
abstract::The association between orbital frontal cortex (OFC) volume and aggression was investigated in an at-risk psychiatric population. Forty-one psychiatric patients were referred for magnetic resonance imaging and a standardized psychometric assessment of aggression (Lifetime History of Aggression-Revised). Nineteen match...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2008.03.007
更新日期:2009-03-31 00:00:00
abstract::We performed spectral analysis on the QRS complex of the electrocardiogram obtained using standard limb leads, sampled at 500 Hz with 12 bit precision in 20 normal subjects and 15 patients with panic disorder. We divided the frequency range of the QRS into two bands based on spectral patterns before and after the post...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(96)02998-8
更新日期:1997-02-07 00:00:00
abstract::Over the years, schizophrenia is speculated to be associated with immune or inflammatory reactions mediated by cytokines. It is proposed that chronic inflammation might damage the micro-vascular system of brain and hamper cerebral blood flow. Scientific evidence suggests that an increase of stress hormone like norepin...
journal_title:Psychiatry research
pub_type: 杂志文章,评审
doi:10.1016/j.psychres.2014.02.004
更新日期:2014-05-15 00:00:00
abstract::The frequency of brain pathology found in the 731 patients who underwent MRI scans in the present study was higher than expected on the basis of reports in the literature (Owens et al., 1980). This underlines the value of a simple MRI examination as an effective diagnostic complement in the investigation of patients w...
journal_title:Psychiatry research
pub_type: 信件
doi:10.1016/0925-4927(92)90007-q
更新日期:1992-08-01 00:00:00
abstract::The authors administered the Tridimensional Personality Questionnaire (TPQ) on two occasions separated by more than 1 month to 30 patients with psychotic disorders to examine hypothesized relationships between affective symptomatology and the TPQ dimension Harm Avoidance. As predicted, changes in Harm Avoidance scores...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(95)02655-g
更新日期:1995-08-28 00:00:00
abstract::Recent studies have reported that patients with unipolar major depression may show a lower whole brain cerebral blood flow (CBF) and reduced regional CBF in frontal, temporal, and parietal lobes. The present study used single photon emission computed tomography (SPECT) with the CBF marker Tc-99m-hexamethylpropyleneami...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0925-4927(93)90012-7
更新日期:1993-06-01 00:00:00
abstract::There is a growing recognition of the importance of encouraging patients with mental health problems to become more active as an efficacious strategy to reduce the disability-associated burden. The aim of the current study was to investigate if there are differences in quality of life (QoL) outcomes between people wit...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2017.08.041
更新日期:2017-12-01 00:00:00
abstract::In Japan, the length of hospital stay (LOS) at psychiatric institutions often exceeds a year, and factors related to such stays have been identified. However, we do not know how multiple patient, hospital, and physician factors interact to determine LOS. Patient data were collected from a psychiatric hospital in Osaka...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2013.09.019
更新日期:2013-12-30 00:00:00