Abstract：
:Abnormalities of both the spontaneous and the stimulated release of growth hormone (GH) have been described in patients with endogenous depression. In this study, six unmedicated male patients with endogenous depression (ICD 296.1/3) were compared with six age-matched healthy men. Levels of GH were determined at 15-minute intervals over 26 hours. A combined releasing hormone test was performed during the last 2 hours of blood sampling. The 24-hour profile of GH secretion was significantly lower in the depressed patients than in the healthy control subjects due to a significantly diminished sleep-related GH secretion. GH stimulation following releasing hormones was lower in the depressed patients than in healthy subjects. Hypersecretion of GH before the stimulation test might therefore not explain the blunted GH response to stimulation that has been observed in depressive patients.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Voderholzer U,Laakmann G,Wittmann R,Daffner-Bujia C,Hinz A,Haag C,Baghai Tdoi
10.1016/0165-1781(93)90080-zsubject
Has Abstractpub_date
1993-06-01 00:00:00pages
215-27issue
3eissn
0165-1781issn
1872-7123pii
0165-1781(93)90080-Zjournal_volume
47pub_type
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