Abstract：
:Platelet serotonin levels were measured in several psychiatric disorders to determine whether they distinguish among major depressive disorder (one or more depressive episodes and no manic episodes), dysthymic disorder (depressive neurosis), and schizophrenic and paranoid disorders. Serotonin levels in 141 subjects were determined using high performance liquid chromatography with electrochemical detection. Serotonin (5HT) levels in control subjects were significantly lower in males than in females. A marked reduction in 5HT levels, as compared to controls, was found in male and female patients with major depressive disorder, but not in dysthymic disorder. A slight but significant reduction in serotonin levels was found in female schizophrenic patients. The reduction in serotonin levels found in major depressive disorder could not be attributed to chronic antidepressant treatment. Liquid chromatography with electrochemical detection used in the present study permits a large-scale investigation.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Le Quan-Bui KH,Plaisant O,Leboyer M,Gay C,Kamal L,Devynck MA,Meyer Pdoi
10.1016/0165-1781(84)90056-8subject
Has Abstractpub_date
1984-10-01 00:00:00pages
129-39issue
2eissn
0165-1781issn
1872-7123pii
0165-1781(84)90056-8journal_volume
13pub_type
杂志文章abstract：:There is increasing evidence that obsessive-compulsive disorder (OCD) is mediated by genetic factors. Although the precise mechanism of inheritance is unclear, recent evidence has pointed towards the involvement of the serotonergic and dopaminergic systems in the disorder's development. Furthermore, early-onset OCD ap...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2004.05.007
更新日期：2004-09-30 00:00:00
abstract：:The study reported herein explored the comprehension of metaphor and irony in schizophrenia during remission, and examined the role of IQ and a theory of mind. Performance of 29 Schizophrenic patients in remission and 22 healthy controls was compared on metaphor and irony comprehension tasks and first- and second-orde...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.04.002
更新日期：2008-01-15 00:00:00
abstract：:The relationship between levels of urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) and symptom scores on the Hamilton Rating Scale for Depression was examined in 31 patients with unipolar depression. Patients with either low MHPG or high MHPG showed significant sleep disturbance in the form of early morning awakening. ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(94)90035-3
更新日期：1994-02-01 00:00:00
abstract：:The relationship between severity of tardive dyskinesia (TD) and the prominence of negative symptoms was assessed in 25 right-handed, medicated schizophrenic patients. TD was quantified using ultrasound detectors and frequency measurement techniques as well as with observer rating scales. Electromechanical studies rev...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(89)90042-5
更新日期：1989-05-01 00:00:00
abstract：:In an attempt to assess the influence of standardized diagnostic interviews on psychological distress in research volunteers, the Visual Analogue Scale (VAS) was used to measure anxiety and depression during the Structured Clinical Interview for DSM-III-R, Non-patient version (SCID). Subjects were 50 adults with conce...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(95)02802-1
更新日期：1996-01-31 00:00:00
abstract：:The contribution of increased rapid eye movement (REM) pressure through repeated, mild, reduction of (REM) sleep to remission from untreated depression was studied over a 5-month period in 20 depressed and 10 control volunteers. Sixty percent of the depressed subjects were in remission at the end of the study. Sixty-f...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(03)00236-1
更新日期：2003-12-01 00:00:00
abstract：:Research on neurobiological impairments in clinical and genetic high risk for developing psychosis individuals (CHR) has identified several brain abnormalities that impact both brain structure and function. The current review will discuss research examining brain abnormalities in clinical and genetic high risk for psy...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.psychres.2019.02.009
更新日期：2019-07-01 00:00:00
abstract：:Performance on neuropsychological tasks was compared in 15 subjects with obsessive-compulsive disorder (OCD) and 15 age- and sex-matched psychiatrically screened control subjects. The tasks chosen are known from studies in other patient groups to demonstrate lateralized abnormalities of visual and limited capacity att...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(93)90104-o
更新日期：1993-11-01 00:00:00
abstract：:The purpose of this work was to study the prevalence of somatic symptoms in patients with treatment-resistant depression (TRD) and their impact on the response to antidepressant treatment. Somatic symptoms were assessed during the screen visit with the Symptom Questionnaire (SQ) somatic symptom (SQ-SS) and somatic wel...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/s0165-1781(03)00063-5
更新日期：2003-05-01 00:00:00
abstract：:The cavum septum pellucidum (CSP) is a fluid-filled cavity in the thin midline structure of the septum pellucidum. The CSP has been linked to several neurodevelopmental disorders, but it also occurs as a result of head injury. The aims were to assess the presence and characterization of the CSP in youth with traumatic...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2013.03.001
更新日期：2013-09-30 00:00:00
abstract：:This study describes 17 publicly available cases of animal hoarding, a special manifestation of hoarding disorder. The cases, which included court documents, animal service documents, photographs, and newspaper clippings, were reviewed by Masters-level clinicians and a veterinarian in private practice. The veterinaria...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.12.127
更新日期：2019-02-01 00:00:00
abstract：:As the serotonin transporter gene (SLC6A4 or 5-HTT) is a key regulator of central serotonergic activity, several association studies between Antisocial Personality Disorder (APD) and the SLC6A4 polymorphisms have been conducted in the last decade. In the present study, the role of both 5-HTTLPR and 5-HTTVNTR polymorph...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.12.018
更新日期：2010-05-15 00:00:00
abstract：:Patients with schizophrenia can have difficulty recognizing emotion, and the impact of this difficulty on social functioning has been widely reported. However, earlier studies did not thoroughly explore how this deficit may vary according to emotion intensity, or how it may differ among individuals and across cultures...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.03.030
更新日期：2019-05-01 00:00:00
abstract：:The objectives of this study were to evaluate the oral health of a group of schizophrenic outpatients and a control group without psychiatric illness. The study also aimed to assess the influence of positive and negative symptomatology on oral health among outpatients with schizophrenia. The DMF-T Index (sum of decaye...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.09.012
更新日期：2011-06-30 00:00:00
abstract：:Obsessive-compulsive disorder (OCD) is characterized by unwanted, intrusive and disturbing thoughts or images that cause anxiety and repetitive behaviours or mental acts to relieve these thoughts or images. Considering controversial aetiology of OCD and growing evidence for the role of inflammation in OCD, the aim of ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113065
更新日期：2020-08-01 00:00:00
abstract：:In schizophrenia, psychomotor slowing and stereotypy are poorly delineated from cognitive deficits like diminished processing speed. Inpatients' performance outcomes on a line-copying task, a task assessing stereotypy and a processing-speed task are compared. Results suggested that psychomotor slowing and stereotypy a...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.01.017
更新日期：2008-10-30 00:00:00
abstract：:To access the saliva level of free 3-methoxy-4-hydroxyphenylglycol (MHPG) as a biological index of anxiety disorders, gender- or age-dependent changes in saliva MHPG level in patients with anxiety disorders were investigated. Saliva MHPG levels in 196 normal volunteers (59 male, 137 female) and 42 outpatients with anx...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(00)00118-9
更新日期：2000-04-10 00:00:00
abstract：:Toxoplasmosis has been previously associated with an increased risk of having schizophrenia in several epidemiological studies. The aim of this prospective study was to examine for the first time a possible association between positive serology to Toxoplasma gondii (T. gondii) and schizophrenia in the Algerian populat...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113293
更新日期：2020-09-01 00:00:00
abstract：:The Delirium Motor Subtype Scale (DMSS) was developed by discerning the best differentiating motor activity symptoms from the Delirium Motor Checklist (DMC), a compilation of psychomotor symptoms from other subjective scales. To broaden its validation we replicated the original work done in a palliative care populatio...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.08.034
更新日期：2013-03-30 00:00:00
abstract：:A cohort of acutely ill, hospitalized patients with chronic psychotic disorders participated in a study of a manualized community reintegration skills training program. Initial data analyses revealed that skill levels improved significantly over the course of treatment, and that higher post-training skill levels were ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(96)03013-2
更新日期：1997-03-24 00:00:00
abstract：:Many young adults who attempt suicide have no discernible mental illness, suggesting an etiology distinct from other psychiatric disorders. Neurological anomalies associated with a history of suicidal behavior may predict future risk. In the present study, we explored changes in neural circuit organization associated ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2014.10.011
更新日期：2015-02-28 00:00:00
abstract：:Implementation science has been recognized as a potential catalyst for health system reform, in part, because of its contribution of well-grounded conceptual theories, often encapsulated in frameworks. Well-designed frameworks provide a semantic structure, a common language by which to guide systematic approaches to s...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.psychres.2019.06.036
更新日期：2020-01-01 00:00:00
abstract：:The factor structure of the Scale for the Assessment of Negative Symptoms (SANS) was examined in a confirmatory factor analysis that used the LISREL procedure. Four models of negative symptom factors were tested in 130 hospitalized schizophrenic patients. A three-factor model of diminished expression, social dysfuncti...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(92)90049-9
更新日期：1992-11-01 00:00:00
abstract：:Eating disorders (EDs) are characterized by symptoms that reflect disturbed eating habits. Available data on EDs largely reflects a traditional latent variable model, whereby symptoms reflect an underlying entity. The network model is an alternative approach where ED symptoms do not reflect an inferred, unobservable c...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.02.027
更新日期：2018-04-01 00:00:00
abstract：:Suicide rates amongst women veterans are significantly higher than rates for their civilian counterparts. However, risk factors for suicide among women veterans remain unclear. The current study examined the impact of exposure to a number of military stressors (e.g., perceived life threat, killing in combat, military ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.02.025
更新日期：2019-04-01 00:00:00
abstract：:Because some evidence favors the hyperarousal model of insomnia, we sought to learn more about the dynamics of this phenomenon during sleep. Polysomnographic data from 30 normative subjects and 86 untreated primary insomnia sufferers recruited from the database of the sleep laboratory were studied for whole nights and...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.03.045
更新日期：2017-07-01 00:00:00
abstract：:Thirty depressed psychiatric inpatients, including 18 with a diagnosis of major depression, and 25 hospital staff controls were compared with respect to cellular immune function--that is, mitogen responsiveness to concanavalin A (con A), phytohemagglutinin (PHA), and pokeweed mitogen (PWM); natural killer cell (NK) ac...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(91)90127-b
更新日期：1991-02-01 00:00:00
abstract：:The rate of smoking is especially high among patients with schizophrenia (SCH) and schizoaffective disorder (SCHAFF). Patients with obsessive-compulsive disorder (OCD) smoke less than the general population. OCD symptoms are more frequent among patients with SCH or SCHAFF than in the general population, but it is stil...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.01.001
更新日期：2006-11-15 00:00:00
abstract：:The memory deficit or forgetfulness hypothesis of obsessive-compulsive disorder (OCD) has received considerable attention and empirical effort over the past decades. The present study aimed to provide a fair test of its various formulations: (1) memory dysfunction in OCD is ubiquitous, that is, manifests irrespective ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.02.006
更新日期：2009-04-30 00:00:00
abstract：:The primary goal of this study was to examine the biochemical abnormalities of late-life major depression by using 3-tesla (3-T) proton magnetic resonance spectroscopy ((1)H-MRS). The antidepressant effects on the biochemical abnormalities were investigated as well. Study participants were 27 elderly patients with maj...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2009.01.003
更新日期：2009-06-30 00:00:00
