Abstract：
:There is increasing evidence that obsessive-compulsive disorder (OCD) is mediated by genetic factors. Although the precise mechanism of inheritance is unclear, recent evidence has pointed towards the involvement of the serotonergic and dopaminergic systems in the disorder's development. Furthermore, early-onset OCD appears to be a subtype that exhibits distinct clinical features and that is associated with greater familial loading. In the present investigation, South African OCD patients (n=252) were stratified according to age of onset and were clinically assessed. Additionally, selected variants in genes encoding serotonergic and dopaminergic components were investigated in a Caucasian OCD subset (n=180). This subgroup was further stratified to evaluate the role that these candidate genes may play in the genetically homogeneous Afrikaner subset (n=80). Analysis of the clinical data revealed an association between early age of onset and an increased frequency of tics, Tourette's disorder, and trichotillomania (TTM). The genetic studies yielded statistically significant results when the allelic distributions of genetic variants in the dopamine receptor type 4 gene (DRD4) were analysed in the Caucasian OCD cohort. These data support a role for the dopaminergic system, which may be relevant to the development of early-onset OCD.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Hemmings SM,Kinnear CJ,Lochner C,Niehaus DJ,Knowles JA,Moolman-Smook JC,Corfield VA,Stein DJdoi
10.1016/j.psychres.2004.05.007subject
Has Abstractpub_date
2004-09-30 00:00:00pages
175-82issue
2eissn
0165-1781issn
1872-7123pii
S0165178104001192journal_volume
128pub_type
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