Abstract:
:Several investigations have reported associations between serotonin 1A (5-HT1A) receptor and major psychiatric disorders, such as schizophrenia and bipolar disorder (BP), making the 5-HT1A receptor gene (HTR1A) a good candidate gene for the pathophysiology of schizophrenia and BP. To evaluate the association between HTR1A and schizophrenia and BP, we conducted a case-control study of Japanese population samples with two single- nucleotide polymorphisms (SNPs), including rs6295 (C-1019G) in HTR1A. In addition, we conducted a meta-analysis of rs6295, which has been examined in other studies. Using one functional single- nucleotide polymorphism (SNP; rs6295) and one tagging SNP (rs878567), we conducted a genetic association analysis of case-control samples (857 schizophrenic patients, 1028 BP patients and 1810 controls) in the Japanese population. Two association studies for schizophrenia and three association studies for BP, including this study, met our criteria for the meta-analysis of rs6295. We found an association between HTR1A and Japanese BP in a haplotype-wise analysis, the significance of which remained after Bonferroni correction. In addition, we detected an association between rs6295 and BP in the meta-analysis (fixed model: P(Z)=0.000400). However, we did not detect an association between HTR1A and schizophrenia in the allele/genotype-wise, haplotype-wise or meta-analysis. HTR1A may play an important role in the pathophysiology of BP, but not schizophrenia in the Japanese population. In the meta-analysis, rs6295 in HTR1A was associated with BP patients.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Kishi T,Okochi T,Tsunoka T,Okumura T,Kitajima T,Kawashima K,Yamanouchi Y,Kinoshita Y,Naitoh H,Inada T,Kunugi H,Kato T,Yoshikawa T,Ujike H,Ozaki N,Iwata Ndoi
10.1016/j.psychres.2010.06.003subject
Has Abstractpub_date
2011-01-30 00:00:00pages
20-6issue
1-2eissn
0165-1781issn
1872-7123pii
S0165-1781(10)00309-4journal_volume
185pub_type
杂志文章abstract::Human corticotropin releasing hormone (h-CRH) was administered to 14 patients with major depression, after premedication with an overnight dose of 1.5 mg dexamethasone. Cortisol response, expressed as area under the time course curve (AUC), was significantly higher in the 14 patients than in a group of 13 age-matched ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(91)90041-m
更新日期:1991-08-01 00:00:00
abstract::Light falling on the retina is converted into an electrical signal which stimulates serotonin synthesis. Previous studies described an increase of plasma and CNS serotonin levels after bright light exposure. Ghrelin and leptin are peptide hormones which are involved in the regulation of hunger/satiety and are related ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2015.05.068
更新日期:2015-10-30 00:00:00
abstract::Posttraumatic Stress Disorder (PTSD) is an anxiety disorder which occurs after a traumatic event. The NR3C1 gene codes for the Glucocorticoid Receptor, which participate in the Hypothalamic-Pituitary-Adrenal (HPA) axis and is altered in PTSD patients. To evaluate whether the NR3C1 gene expression in peripheral blood c...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2020.112797
更新日期:2020-02-01 00:00:00
abstract::This study measured changes in regional cerebral blood flow (rCBF) during the complex cognitive task of meditation using single photon emission computed tomography. Eight experienced Tibetan Buddhist meditators were injected at baseline with 7 mCi HMPAO and scanned 20 min later for 45 min. The subjects then meditated ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0925-4927(01)00074-9
更新日期:2001-04-10 00:00:00
abstract::A great deal of variation in opinion and practice remains regarding the most efficient use of electroconvulsive therapy (ECT) in treating depression. In this study we used an estimate of maximal improvement point to look at the rate of response to conventional ECT (one seizure per session, three times per week) in 66 ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(84)90065-9
更新日期:1984-03-01 00:00:00
abstract::Performance of the Wisconsin Card Sorting Test (WCST) and related brain-activation patterns reflect both task learning and execution. Normal subjects learned the WCST prior to performance during slow SPECT ligand infusion. Blood flow increased in bilateral inferior frontal, right middle and inferior parietal cortices....
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0925-4927(98)00003-1
更新日期:1998-04-10 00:00:00
abstract::Deficits in facial emotion recognition have been recognised in Chinese patients diagnosed with schizophrenia. This study examined the relationship between chronicity of illness and performance of facial emotion recognition in Chinese with schizophrenia. There were altogether four groups of subjects matched for age and...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2011.07.001
更新日期:2011-12-30 00:00:00
abstract::Event schemas, the conceptualization of past experience, in schizophrenic patients were examined based upon script theory. Forty schizophrenic patients and 40 age- and education-matched normal control subjects participated in this study. This experiment consisted of three tasks. In the recall task, subjects recalled a...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(99)00051-7
更新日期:1999-10-11 00:00:00
abstract::Although social skills training (SST) is an effective approach for improving social skills for schizophrenia, the motivational deficit attenuates its efficacy. Virtual reality (VR) applications have allowed individuals with mental disabilities to enhance their motivation for rehabilitation. We compared SST using VR ro...
journal_title:Psychiatry research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psychres.2011.04.003
更新日期:2011-09-30 00:00:00
abstract::Determining meaningful activation thresholds in functional magnetic resonance imaging (fMRI) paradigms is complicated by several factors. These include the time-series nature of the data, the influence of physiological rhythms (e.g. respiration) and vacillations introduced by the experimental design (e.g. cueing). We ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0925-4927(97)00024-3
更新日期:1997-08-08 00:00:00
abstract::We aimed to assess the association between core cerebrospinal fluid (CSF) biomarkers, regional brain atrophy and clinical severity in the Alzheimer's disease (AD) continuum, as well as to investigate how cognitive reserve (CR) may modulate these putative associations. Forty-nine subjects (11 controls, 10 patients with...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2010.12.001
更新日期:2011-06-30 00:00:00
abstract::Research on the sub-clinical condition of schizotypy suggests that it is associated with mixed handedness. To date, however, this research has focussed on undergraduate populations. If the association between schizotypy and mixed-handedness is the result of an underlying neurological trait, it is important to demonstr...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2010.11.019
更新日期:2011-05-15 00:00:00
abstract::In recent years, research focusing on childhood has reported that communication difficulties in autism spectrum disorder (ASD) are related to the social reciprocity difficulties inherent to ASD, as well as severe social anxiety and decreased verbal fluency. However, there have been no reports regarding these correlati...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2020.113503
更新日期:2020-12-01 00:00:00
abstract::Functional magnetic resonance imaging in a Go/Nogo task was employed to investigate the relationship between trait impulsivity and brain activation during motor response inhibition. We found a positive correlation between motor impulsivity and activation of bilateral ventrolateral prefrontal cortex during successful i...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2010.04.006
更新日期:2010-07-30 00:00:00
abstract::Ten nondepressed patients with obsessive-compulsive disorder (OCD) who were characterized by predominant checking rituals were compared with 10 age- and sex-matched control subjects. Hemispheric and regional cerebral blood flow levels (rCBF) were measured with positron emission tomography (H2 15O) across four conditio...
journal_title:Psychiatry research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0165-1781(96)02697-2
更新日期:1996-03-29 00:00:00
abstract::First-episode psychosis typically emerges during late adolescence or young adulthood, interrupting achievement of crucial educational, occupational, and social milestones. Recovery-oriented approaches to treatment may be particularly applicable to this critical phase of the illness, but more research is needed on the ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2011.05.039
更新日期:2011-10-30 00:00:00
abstract::Some, but not all studies have reported that a single dose of benzodiazepine affects growth hormone (GH) and cortisol secretion in healthy volunteers. The majority of studies that found GH elevations after benzodiazepine administration did not use placebo trials. The present placebo-controlled investigation determined...
journal_title:Psychiatry research
pub_type: 临床试验,杂志文章
doi:10.1016/0165-1781(86)90014-4
更新日期:1986-08-01 00:00:00
abstract::Although psychometrically-defined executive function deficits (EFDs) and ecologically valid functional outcomes have been documented among youth with bipolar I (BP-I) disorder, little is known about their association. We hypothesized that EFDs would be associated with significant ecologically valid impairments beyond ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2010.08.029
更新日期:2011-03-30 00:00:00
abstract::Performance on neuropsychological tasks was compared in 15 subjects with obsessive-compulsive disorder (OCD) and 15 age- and sex-matched psychiatrically screened control subjects. The tasks chosen are known from studies in other patient groups to demonstrate lateralized abnormalities of visual and limited capacity att...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(93)90104-o
更新日期:1993-11-01 00:00:00
abstract::Excessive interpersonal dependency has been described in depression and addictive disorders. Moreover, excessive dependency and suicidality are linked in psychiatric subjects, but their relationships have not been studied in specific addictions. Separate samples of female anorectic patients (n=150), female bulimic pat...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2004.06.022
更新日期:2005-11-15 00:00:00
abstract::Psychopathy is a cluster of personality traits associated with high rates of aggression. While research on psychopathic traits largely focuses on neurobiological factors implicated in aggression, other research suggests that contextual factors, such as social exclusion, also contribute to promoting aggression. Yet, th...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.07.024
更新日期:2018-10-01 00:00:00
abstract::Depressive patients exhibit symptoms of impaired regulation of wakefulness with hyperarousal and agitation as well as difficulties to falling asleep and preserving sleep continuity. Changes in hypocretin (hcrt) levels as polypeptides with impact on arousal and sleep-wake-regulation have been discussed in affective dis...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2011.06.004
更新日期:2011-12-30 00:00:00
abstract::Implementation science is focused on maximizing the adoption, appropriate use, and sustainability of effective clinical practices in real world clinical settings. Many implementation science questions can be feasibly answered by fully experimental designs, typically in the form of randomized controlled trials (RCTs). ...
journal_title:Psychiatry research
pub_type: 杂志文章,评审
doi:10.1016/j.psychres.2019.06.027
更新日期:2020-01-01 00:00:00
abstract::The study focuses on the adaptation into Spanish and on the validation of the Social Phobia Spectrum Self-Report (SHY-SR) and the Obsessive-Compulsive Spectrum Self-Report (OBS-SR). The questionnaires were designed to measure a broad range of subtle and atypical features related to social anxiety and obsessive-compuls...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2005.07.025
更新日期:2006-06-15 00:00:00
abstract::This study examined compulsive sexual behavior (CSB) and psychopathology in a treatment-seeking sample of men in São Paulo, Brazil. Eighty-six men (26% gay, 17% bisexual, 57% heterosexual) who met diagnostic criteria for excessive sexual drive and sexual addiction completed assessments consisting of the Mini Internati...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2013.01.021
更新日期:2013-10-30 00:00:00
abstract::There is growing concern over the potential for increased suicide risk in vulnerable populations as the COVID-19 pandemic unfolds. To contextualize this risk during the first weeks of the nationwide lockdown efforts, we had 1,013 U.S. adults complete questionnaires assessing worries over COVID-19, insomnia severity, a...
journal_title:Psychiatry research
pub_type: 信件
doi:10.1016/j.psychres.2020.113134
更新日期:2020-08-01 00:00:00
abstract::We used functional magnetic resonance imaging (fMRI) to investigate dysfunction in the amygdala and orbitofrontal cortex in adolescents with disruptive behavior disorders and psychopathic traits during a moral judgment task. Fourteen adolescents with psychopathic traits and 14 healthy controls were assessed using fMRI...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2011.07.008
更新日期:2011-12-30 00:00:00
abstract::Resting state functional magnetic resonance imaging (fMRI) was used to measure whole brain functional connectivity within specific networks hypothesised to be more affected in dementia with Lewy bodies (DLB) (a disease characterised by prominent attentional deficits, spontaneous motor features of parkinsonism and depr...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2014.06.004
更新日期:2014-09-30 00:00:00
abstract::We assessed the course of psychiatric disorders in 23 cervical dystonia patients by using the structured clinical interview for DSM-IV and different rating scales. Patients were studied on two occasions 5 years apart. There were no differences in psychiatric disorders and severity of psychiatric symptoms between the t...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2015.07.076
更新日期:2015-09-30 00:00:00
abstract::In this study, we investigated whether polymorphisms of the dopamine D4 receptor (DRD4) gene were associated with psychotic symptomatology rather than with a unique diagnosis such as schizophrenia. A number of association studies between the DRD4 gene 48 bp-VNTR polymorphism at exon 3 and psychotic disorders have been...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2006.12.011
更新日期:2007-12-03 00:00:00