Abstract：
:Determining meaningful activation thresholds in functional magnetic resonance imaging (fMRI) paradigms is complicated by several factors. These include the time-series nature of the data, the influence of physiological rhythms (e.g. respiration) and vacillations introduced by the experimental design (e.g. cueing). We present an empirical threshold for each subject and each fMRI experiment that takes these factors into account. The method requires an additional fMRI data set as similar to the experimental paradigm as possible without dichotomously varying the experimental task of interest. A letter fluency task was used to illustrate this method. This technique differs from classical methods since the Pearson correlation probability values tabulated from statistical theory are not used. Rather each subject defines his or her own set of threshold probability values for correlations. It is against these empirical thresholds, not Pearson's, that an experimental fMRI correlation is assessed.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Arndt S,Gold S,Cizadlo T,Zheng J,Ehrhardt JC,Flaum Mdoi
10.1016/s0925-4927(97)00024-3subject
Has Abstractpub_date
1997-08-08 00:00:00pages
15-22issue
1eissn
0165-1781issn
1872-7123journal_volume
75pub_type
杂志文章abstract：:A recent genome-wide association study (GWAS) for major depressive disorder (MDD) in Chinese women identified a single-nucleotide polymorphism (SNP), rs12415800, near the Sirtuin1 (SIRT1) gene as one of the top candidate loci. However, no study has shown a genetic association between SIRT1 and completed suicide, which...
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