Abstract：
:We used functional magnetic resonance imaging (fMRI) to investigate dysfunction in the amygdala and orbitofrontal cortex in adolescents with disruptive behavior disorders and psychopathic traits during a moral judgment task. Fourteen adolescents with psychopathic traits and 14 healthy controls were assessed using fMRI while they categorized illegal and legal behaviors in a moral judgment implicit association task. fMRI data were then analyzed using random-effects analysis of variance and functional connectivity. Youths with psychopathic traits showed reduced amygdala activity when making judgments about legal actions and reduced functional connectivity between the amygdala and orbitofrontal cortex during task performance. These results suggest that psychopathic traits are associated with amygdala and orbitofrontal cortex dysfunction. This dysfunction may relate to previous findings of disrupted moral judgment in this population.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Marsh AA,Finger EC,Fowler KA,Jurkowitz ITN,Schechter JC,Yu HH,Pine DS,Blair RJRdoi
10.1016/j.pscychresns.2011.07.008subject
Has Abstractpub_date
2011-12-30 00:00:00pages
279-286issue
3eissn
0165-1781issn
1872-7123pii
S0925-4927(11)00248-4journal_volume
194pub_type
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pub_type： 临床试验,杂志文章
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