Abstract:
:Positron emission tomography (PET) studies have reported an association between reduced striatal dopamine D2/3 receptor availability and higher scores on self-report measures of trait impulsivity in healthy adults. However, impulsivity is a multi-faceted construct, and it is unclear which aspect(s) of impulsivity might be driving these associations. The current study aimed to investigate the relationship between limbic (ventral) striatal D2/3 receptor availability and individual components of impulsivity (attentional, motor and non-planning) using the Barratt Impulsiveness Scale (BIS-11) and [(11)C]raclopride PET in 23 healthy volunteers. A partial correlational analysis showed a significant association between non-planning impulsiveness (lack of forethought or 'futuring') and limbic D2/3 receptor availability, which was only apparent after the exclusion of potential dissimulators (indexed by high scores on impression management). Our findings suggest that non-planning impulsiveness is associated with individual variation in limbic striatal D2/3 receptor availability and that different facets of impulsivity may have specific neurochemical correlates. Future studies that combine D2/3 receptor imaging with behavioral measures of impulsivity are required to further elucidate the precise relationship between individual components of trait impulsivity and brain dopaminergic function.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Reeves SJ,Polling C,Stokes PR,Lappin JM,Shotbolt PP,Mehta MA,Howes OD,Egerton Adoi
10.1016/j.pscychresns.2011.09.011subject
Has Abstractpub_date
2012-04-30 00:00:00pages
60-4issue
1eissn
0165-1781issn
1872-7123pii
S0925-4927(11)00338-6journal_volume
202pub_type
杂志文章abstract::A notable number of young adults struggle to control impulsive behavior, resulting in impairment and distress. Assessments of problematic sexual behavior (PSB) have noted clinical differences relative to other populations, but neurocognitive findings have varied. This analysis assesses the clinical presentation and ne...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.09.044
更新日期:2016-12-30 00:00:00
abstract::High motivation and belief in a cause have been reported to be protective against posttraumatic stress disorder (PTSD), while below-average intellectual functioning and poor educational achievements have been reported to increase vulnerability to PTSD. The main goal of this study was to assess the effect of education,...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(01)00365-1
更新日期:2002-01-31 00:00:00
abstract::The purpose of this study was to examine social context processing in persons with schizophrenia. A secondary goal was to examine the ecological validity of these measures (i.e. how they relate to social behavior in the treatment setting). The performance of 35 persons with DSM-IV diagnosed schizophrenia and/or schizo...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(02)00004-5
更新日期:2002-03-15 00:00:00
abstract::Using lexical content analysis (linguistic inquiry and word count), the hypotheses that social detachment and impaired cognitive processing are typical for alexithymia are investigated. Based on clinical interviews with 32 outpatients (mixed diagnoses), we found support for the hypotheses for the externally oriented t...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2010.06.032
更新日期:2011-11-30 00:00:00
abstract::We aimed to investigate UFD1L polymorphisms in schizophrenia and in relation to cognition. A total of 299 cases and 363 controls were genotyped, and 130 patients completed nine neuropsychological tests. We found that rs5992403 AA-genotype carriers showed lower scores on the set-shifting task. Therefore, UFD1L may part...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2013.03.035
更新日期:2013-08-30 00:00:00
abstract::The seven-factor model of personality developed by Cloninger and colleagues describes personality as a function of developmental aspects of character superimposed on heritable dimensions of temperament. The objective of this study was to determine whether this model could be applied to early childhood. We tested a pre...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(02)00008-2
更新日期:2002-04-15 00:00:00
abstract::Aim of this study consisted in assessing the 24-h heart rate variability (HRV), a measure of autonomic nervous system (ANS) imbalance, in 21 adolescents with functional hypothalamic amenorrhea (FHA, 11 normogonadotropic, N-FHA, and 10 hypogonadotropic, Hy-FHA) compared to 21 patients with anorexia nervosa (AN) and 21 ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2013.11.012
更新日期:2014-02-28 00:00:00
abstract::If Borderline Personality Disorder (BPD) is characterized by an underlying emotional sensitivity, individuals with this disorder would be expected to demonstrate accurate identification of emotional expressions at earlier stages of expression (i.e., lower thresholds of facial expressivity across all emotional valences...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2010.12.019
更新日期:2011-05-15 00:00:00
abstract::Mindfulness-based strategies show promise for targeting the construct of impulsivity and associated variables among problematic alcohol users. This study examined the moderating role of intervention (mindfulness vs relaxation vs control) on trait impulsivity and three outcomes examined post-intervention (negative affe...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.04.115
更新日期:2016-08-30 00:00:00
abstract::Screening for psychiatric disorders may be hampered by traditional measures that increase participant burden and elicit negative responses via denial and social desirability biases. This study examined the utility of a wellbeing measure to identify psychopathology and suicide risk in adolescent participants. 1,579 stu...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.07.034
更新日期:2018-10-01 00:00:00
abstract::The aim of this study was to investigate findings of positron emission tomography with 18F-fluorodeoxyglucose (18F-FDG PET) in normal subjects to clarify the effects of sex differences, aging, and cognitive reserve on cerebral glucose metabolism. Participants comprised 123 normal adults who underwent 18F-FDG PET and a...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2013.10.009
更新日期:2014-01-30 00:00:00
abstract::Parental style and Cloninger's dimensions are associated with psychosis, but it is still unclear whether temperament, character and parenting variables are linked to specific psychotic symptoms. This study extends previous research exploring these issues. 78 patients with psychosis and 156 control subjects were recrui...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.08.066
更新日期:2018-11-01 00:00:00
abstract::The severity of depressive symptoms across two discrete mental disorders should be evaluated with the same psychometrically validated tools. In patients with schizophrenia the Calgary Depression Rating Scale (CDSS) is recommended for evaluating depressive symptoms. The aim of this study was to validate the CDSS in pat...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.06.062
更新日期:2018-10-01 00:00:00
abstract::Cholesterol, sodium, potassium, and serum glucose were examined to determine if they could predict status on the dexamethasone suppression test (DST) in 59 depressed prepubertal psychiatric inpatients and 21 nondepressed psychiatric inpatients. Multivariate analyses found that none of these variables, alone or combine...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(89)90036-x
更新日期:1989-08-01 00:00:00
abstract::Acute Stress Disorder (ASD) was first included in the DSM-IV in 1994. It was proposed to account for traumatic responding in the early post trauma phase and to act as an identifier for later Posttraumatic Stress Disorder (PTSD). Unlike PTSD it included a number of dissociative indicators. The revised DSM-5 PTSD criter...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2014.11.063
更新日期:2015-02-28 00:00:00
abstract::Trait anxiety, a personality dimension, has been characterized by functional consequences such as increased distractibility, attentional bias in favor of threat-related information and hyper-responsive amygdala. However, literature on the association between resting state brain functional connectivity, as studied usin...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2015.07.006
更新日期:2015-10-30 00:00:00
abstract::First-episode psychosis typically emerges during late adolescence or young adulthood, interrupting achievement of crucial educational, occupational, and social milestones. Recovery-oriented approaches to treatment may be particularly applicable to this critical phase of the illness, but more research is needed on the ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2011.05.039
更新日期:2011-10-30 00:00:00
abstract::Limited research has examined differences in well-established suicide correlates between individuals with various histories of suicidality within the ideation to action framework. We hypothesized that individuals without a history of elevated suicidality would exhibit lowest levels of suicide correlates (perceived bur...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.08.038
更新日期:2016-11-30 00:00:00
abstract::We investigated whether symptom overreporting affects the dose-response relationship between self-reported abuse severity and psychiatric symptoms in two samples. The first sample (N=599) consisted of adults who had previously reported to a public commission that they had been witnesses to or victims of childhood sexu...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2014.03.018
更新日期:2014-07-30 00:00:00
abstract::Similar to members of the public, people with mental illness may exhibit general negative automatic prejudice against their own group. However, it is unclear whether more specific negative stereotypes are automatically activated among diagnosed individuals and how such automatic stereotyping may be related to self-rep...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2010.08.024
更新日期:2011-03-30 00:00:00
abstract::Glucocorticoids are known to modulate memory functions, with elevated cortisol levels being associated with impaired declarative memory. This specific effect has been shown in several studies using pharmacological doses of cortisol. The present study was designed to assess the effects of stress-induced cortisol elevat...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2004.11.007
更新日期:2005-04-30 00:00:00
abstract::This study was carried out to investigate the association of a polymorphism of the CTLA-4 gene, at position 49 of exon 1, with schizophrenia in the Korean population. Among Korean patients diagnosed with schizophrenia according to DSM-IV, 116 patients who met the selection criteria were recruited for the study. One hu...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(02)00031-8
更新日期:2002-05-15 00:00:00
abstract::The neurodevelopment and functioning of the central nervous system, and especially the cerebral cortex, have basic importance to understand neuropsychiatric disorders like autism. Fibroblast growth factor-2 (FGF-2) plays a very important role in the development and functioning of the cortex. FGF-2 is related to develo...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2017.07.028
更新日期:2017-11-01 00:00:00
abstract::The present follow-up study examines the associations between cognition and parent-rated internalizing problems among adolescents with early-onset schizophrenia (EOS) at baseline (T1) and self-rated internalizing problems 13 years later (T2). Twelve individuals (8 male/4 female) with EOS and 30 healthy controls (16 ma...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.04.033
更新日期:2018-07-01 00:00:00
abstract::The Unified Biosocial Theory of Personality developed by Cloninger has been applied in different cultures. Distribution by age and sex of the Temperament and Character Inventory (TCI) dimensions were assessed cross-culturally for samples in Spain and the USA. Three non-clinical samples were included: i) 404 participan...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2010.07.021
更新日期:2011-04-30 00:00:00
abstract::Prior studies have confirmed a bias against disconfirmatory evidence (BADE) in schizophrenia which has been associated with delusions. However, its role in the pathogenesis of psychosis is yet unclear. The objective was to investigate BADE for the first time in subjects with an at-risk-mental-state for psychosis (ARMS...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.02.028
更新日期:2016-04-30 00:00:00
abstract::We studied the complexity of the electroencephalogram (EEG) in schizophrenic patients by estimating the first Lyapunov exponent (L1), which might serve as an indicator of the specific brain function in schizophrenia. We recorded the EEG from 25 schizophrenic patients (12 male, 13 female; age=25.1+/-7.0 years) fulfilli...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0925-4927(00)00052-4
更新日期:2000-05-15 00:00:00
abstract::Gilles de la Tourette Syndrome (GTS) and obsessive-compulsive disorder (OCD) share obsessive-compulsive phenomena. The aims of this study were to compare the OC symptom distribution between GTS and OCD and to investigate whether a subdivision of these phenomena into obsessions, compulsions and 'impulsions' is useful i...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(01)00219-0
更新日期:2001-03-25 00:00:00
abstract::Voxel-based morphometry and functional magnetic resonance imaging demonstrated severe atrophy and decreased activation of visual attention areas and occipital lobes in a patient with early posterior cortical atrophy compared with healthy controls and patients with early Alzheimer's disease. Our complex approach indica...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2008.01.006
更新日期:2008-11-30 00:00:00
abstract::Depression is associated with attentional biases for emotional information that are proposed to reflect stable vulnerability factors for the development and recurrence of depression. A key question for researchers is whether those who have recovered from depression also exhibit attentional biases, and if so, how simil...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2015.09.036
更新日期:2015-12-15 00:00:00