Polymorphisms in schizophrenia candidate gene UFD1L may contribute to cognitive deficits.

Abstract:

:We aimed to investigate UFD1L polymorphisms in schizophrenia and in relation to cognition. A total of 299 cases and 363 controls were genotyped, and 130 patients completed nine neuropsychological tests. We found that rs5992403 AA-genotype carriers showed lower scores on the set-shifting task. Therefore, UFD1L may participate in the core cognitive deficits observed in schizophrenia.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Ota VK,Berberian AA,Gadelha A,Santoro ML,Ottoni GL,Matsuzaka CT,Mari JJ,Melaragno MI,Lara DR,Smith MA,Belangero SI,Bressan RA

doi

10.1016/j.psychres.2013.03.035

subject

Has Abstract

pub_date

2013-08-30 00:00:00

pages

110-3

issue

1

eissn

0165-1781

issn

1872-7123

pii

S0165-1781(13)00166-2

journal_volume

209

pub_type

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