Abstract:
:To study the effect of concurrent use of second-generation antipsychotics (SGAs) on metabolic syndrome (MetS) components conferring increased cardiovascular risk in a sample of human immunodeficiency virus (HIV)-infected adults taking antiretroviral therapy (ART). A retrospective study of participants consecutively recruited at the UCSD HIV Neurobehavioral Research Program examined effects of combined ART and SGAs on body mass index (BMI), nonfasting serum lipids, diabetes mellitus (DM) incidence, and mean arterial pressure (MAP). Metabolic outcome variables and covariates were compared using t-tests, Chi-squared or Fisher's exact tests. Linear and logistic multivariable models explored metabolic outcomes for participants taking (SGA+) or not taking (SGA-) concomitant SGAs, after controlling for demographic and HIV disease- and ART-related covariates. Of 2229 HIV-infected participants, 12% (N=258) were treated with SGAs. In multivariable models adjusted for relevant covariates, the SGA+ group had significantly higher mean triglycerides, significantly higher odds of DM, significantly higher MAPs and marginally higher BMI. The use of SGAs in HIV-infected adults taking ART was independently associated with worse indicators of MetS and cardiovascular risk. Aggressive monitoring for the metabolic complications from concurrent SGA and ART is indicated in all patients receiving these medication combinations.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Ferrara M,Umlauf A,Sanders C,Meyer JM,Allen McCutchan J,Duarte N,Hampton Atkinson J,Grant I,Ellis RJ,CHARTER Group.doi
10.1016/j.psychres.2014.04.015subject
Has Abstractpub_date
2014-08-15 00:00:00pages
201-8issue
1-2eissn
0165-1781issn
1872-7123pii
S0165-1781(14)00293-5journal_volume
218pub_type
杂志文章abstract::Depression is associated with cognitive impairment and suicidality. The independent association between cognitive impairment and suicidality is less clear. We examined the relationship between suicidal ideation and cognitive impairment in a sample of 50 veterans with depressive disorder diagnoses. Using zero-inflated ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2020.112833
更新日期:2020-01-30 00:00:00
abstract::Moclobemide is a reversible, short-acting monoamine oxidase inhibitor (MAO1), specific for MAO A. To study moclobemide effects on the tyramine pressor response, we gave 12 depressed patients (2 males, 10 females; mean age 47, SD 11 years) an i.v. tyramine test after 7 days drug free. The mean (+/- SD) tyramine dose to...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(87)90036-9
更新日期:1987-11-01 00:00:00
abstract::Choline chloride (2g q.i.d.) and placebo were admin stered to nine young adults in a placebo-drug-placebo design. Subjects took memory tests at the end of both placebo periods and at the end of the choline period. All nine subjects had participated in a previous study in which 1.0 mg of physostigmine infused over a 1-...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(80)90071-2
更新日期:1980-05-01 00:00:00
abstract::Face perception plays a foundational role in the social world. This perceptual ability is deficient in schizophrenia. A noise-filtering mechanism is essential for perceptual processing. It remains unclear as to whether a specific noise-filtering mechanism is implicated in the face perception problem or a general noise...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2014.11.035
更新日期:2015-02-28 00:00:00
abstract::MIR137, a brain expressed miRNA, has been identified as a top novel susceptibility gene for schizophrenia (SZ). 230 healthy participants completed the Stroop test and were genotyped for a functional Variable Number Tandem Repeat (VNTR) in MIR137 gene. MIR137 VNTR genotypes were associated with differences in Stroop fa...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.01.006
更新日期:2016-02-28 00:00:00
abstract::Baseline 8 a.m. adrenocorticotropic hormone (ACTH) and cortisol levels and the postdexamethasone ACTH/cortisol values at 8 a.m. and 4 p.m. were determined in 86 depressed females diagnosed using DSM-III criteria. Postdexamethasone ACTH and cortisol values were significantly correlated with their baseline levels. We ha...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(90)90013-u
更新日期:1990-11-01 00:00:00
abstract::The construction and initial psychometric evaluation of an interview assessment of clinically significant impulsivity (Lifetime History of Impulsive Behaviors; LHIB) is presented. Personality-disordered and control subjects participated by completing self-report measures of depression, anxiety and social desirability,...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2003.12.021
更新日期:2004-04-30 00:00:00
abstract::The Morningness-Eveningness Questionnaire (MEQ) is among the most commonly used scales to measure chronotype. We aimed to evaluate psychometric properties and clinical correlates of MEQ in bipolar disorder. Patients with a clinical diagnosis of bipolar disorder (n = 53) answered questionnaires for chronotype (MEQ), mo...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.02.004
更新日期:2018-04-01 00:00:00
abstract::Biased processing of threatening stimuli, including attention toward and away from threat, has been implicated in the development and maintenance of PTSD symptoms. Research examining theoretically-derived mechanisms through which dysregulated processing of threat may be associated with PTSD is scarce. Negative affect,...
journal_title:Psychiatry research
pub_type: 临床试验,杂志文章
doi:10.1016/j.psychres.2019.112674
更新日期:2020-02-01 00:00:00
abstract::Redundant clothing (RC) is a readily observable feature of schizophrenia. While abnormal thermoregulation, thyroid dysfunction and autonomic dysregulation have been postulated to account for RC, no identified factor yet conclusively explains this enigmatic behaviour. This study attempted to determine the cause(s) of R...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2015.03.029
更新日期:2015-06-30 00:00:00
abstract::This study measured changes in regional cerebral blood flow (rCBF) during the complex cognitive task of meditation using single photon emission computed tomography. Eight experienced Tibetan Buddhist meditators were injected at baseline with 7 mCi HMPAO and scanned 20 min later for 45 min. The subjects then meditated ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0925-4927(01)00074-9
更新日期:2001-04-10 00:00:00
abstract::Computed tomographic (CT) scans of brains of patients with borderline personality disorder and normal volunteers were analyzed for ventricle-brain ratios, third ventricular size, and evidence of frontal lobe atrophy. There were no significant differences between the two groups on any of these measures except for a nar...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(89)90126-1
更新日期:1989-02-01 00:00:00
abstract:OBJECTIVE:To examine the construct validity of the 9 item Traumatic Events Questionnaire (TEQ) and to evaluate the extent to which experiences of trauma assessed using the TEQ are associated with symptoms of psychiatric disorders among 3342 pregnant women in Lima, Peru. METHODS:Symptoms of depression were assessed usi...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2017.08.016
更新日期:2017-11-01 00:00:00
abstract::The assessment of mental health consumers' functional independence is a core duty of occupational therapists. Despite the clear impact of cognition on functional outcomes, it is not always routinely assessed. We sought to explore the relationship between cognition and functional independence as well as to describe whi...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2013.02.032
更新日期:2013-06-30 00:00:00
abstract::Pathological gamblers (PGs) perform differently on neurocognitive tests than do healthy controls (HC). The aim of this study was to assess "waiting ability" - a major components of inhibition control-using a modified Stop Signal Task (SST) in a population of male PGs (N=55), and HCs (N=53). Results indicated no differ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2015.09.038
更新日期:2015-12-15 00:00:00
abstract::The limbic system plays an important role in regulating the hypothalamic-pituitary-adrenal (HPA) axis as well as aspects of emotion, and both neuroendocrine disturbance and increased negative emotionality are associated with risk for developing affective disorders. However, the extent to which the architecture of conn...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2011.07.015
更新日期:2012-01-30 00:00:00
abstract::Major depressive disorder is associated with lower medial prefrontal cortex volumes. The role that gender might play in moderating this relationship and what particular medial prefrontal cortex subregion(s) might be implicated is unclear. Magnetic resonance imaging was used to assess dorsal, ventral, and anterior cing...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2015.06.005
更新日期:2015-08-30 00:00:00
abstract::Many studies have demonstrated that depression is associated with a worse cardiovascular outcome and increased risk of death in those experiencing an acute coronary syndrome (ACS). Recent studies have suggested, however, that any association is strongly influenced by the timing of the depression, with post-ACS depress...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2010.07.015
更新日期:2011-02-28 00:00:00
abstract::Repetitive transcranial magnetic stimulation (rTMS) is currently undergoing active investigation for use in the treatment of major depression. Recent research has indicated that current methods used to localize the site of stimulation in dorsolateral prefrontal cortex (DLPFC) are significantly inaccurate. However, lit...
journal_title:Psychiatry research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.pscychresns.2006.04.006
更新日期:2006-11-22 00:00:00
abstract::Atypical sensory processing has been described in autism spectrum disorder. The goal of this systematic review is to investigate the links between sensory processing, adaptive behaviours, and attention skills in children with autism spectrum disorder. The PRISMA guidelines were followed and a search was conducted usin...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.09.023
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Mindfulness-based cognitive therapy (MBCT) is an increasingly popular treatment for major depression and anxiety disorder, but has shown inconsistent efficacy for bipolar disorder (BD). Therefore, we conducted a meta-analysis to assess the general efficacy of MBCT for BD. METHODS:Ten studies were identified...
journal_title:Psychiatry research
pub_type: 杂志文章,meta分析
doi:10.1016/j.psychres.2020.113116
更新日期:2020-08-01 00:00:00
abstract::Recent studies of schizophrenia have implicated deficits in processes related to working memory, but the cognitive features of these deficits have been incompletely characterized. We used a modified Brown-Peterson paradigm to compare working memory in patients with schizophrenia and in normal control subjects. Distrac...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(95)02589-3
更新日期:1995-03-27 00:00:00
abstract::Posttraumatic stress disorder (PTSD) and social anxiety disorder (SAD) are highly comorbid (Collimore et al., 2010). Trauma may present a shared environmental factor contributing to the development of comorbidity; however, existent research has been hampered by use of restrictive samples and limitations in the range o...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.10.036
更新日期:2016-12-30 00:00:00
abstract::Negative life events are elevated in suicidal populations. Diathesis-stress and kindling effects models suggest different mechanisms by which negative life events increase suicide risk. Different forms of negative life events - risk-taking behaviors and stressors - may have different effects on non-fatal suicide attem...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.09.032
更新日期:2018-12-01 00:00:00
abstract::The aim of the study was to determine the differences between expression levels of certain miRNAs, as their association with schizophrenia has been well presented in the literature, and to investigate their relation to treatment resistance in schizophrenic patients. Three groups were formed: 1) treatment-resistant gro...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.08.037
更新日期:2016-11-30 00:00:00
abstract::The dysconnectivity hypothesis proposes that abnormal resting state connectivity within the default-mode network (DMN) plays a key role in schizophrenia. Little is known, however, about alterations of the network homogeneity (NH) of the DMN in unaffected siblings of patients with schizophrenia. Unaffected siblings hav...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2014.08.014
更新日期:2014-12-30 00:00:00
abstract::Although psychometrically-defined executive function deficits (EFDs) and ecologically valid functional outcomes have been documented among youth with bipolar I (BP-I) disorder, little is known about their association. We hypothesized that EFDs would be associated with significant ecologically valid impairments beyond ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2010.08.029
更新日期:2011-03-30 00:00:00
abstract::Metacognitive theories describe relationships between mental-affective self-states, including the capacity of one self-state to reflect upon another self-state. The assimilation model is a metacognitive approach that understands self-states as made of traces of experiences at different levels of integration. Psycholog...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2010.11.001
更新日期:2011-11-30 00:00:00
abstract::We examined the executive control of emotional information and its relationship to social functioning in individuals at risk for schizophrenia, defined by high social anhedonia (SA). Using the same structure as the Attentional Network Test (ANT), we developed a measure of executive control of emotional information (AN...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2011.12.023
更新日期:2012-05-15 00:00:00
abstract::The purpose of this study was to investigate the influence of clozapine on plasma serotonin, platelet serotonin and monoamine oxidase (MAO) levels in schizophrenic patients and to compare their results with those of unmedicated healthy controls. Groups of 20 outpatients with schizophrenia and 20 healthy controls match...
journal_title:Psychiatry research
pub_type: 临床试验,杂志文章
doi:10.1016/j.psychres.2005.12.009
更新日期:2007-01-15 00:00:00