Abstract：
:We aimed to investigate whether microRNA-let-7d (miRNA-let-7d) and miRNA-107 may serve as diagnostic and therapeutic biomarkers of attention deficit hyperactivity disorder (ADHD). The relative expression level of miRNA-let-7d and miRNA-107 in patients with ADHD and in a healthy control group was detected by real-time polymerase chain reaction. The blood samples were collected at 6 weeks after repetitive transcranial magnetic stimulation (rTMS) or atomoxetine (ATX) in ADHD patients, and the relative expression levels of the two miRNAs before and after treatments were compared. There were significant differences in the expression level of miRNA-let-7d between ADHD patients and healthy children, as well as before and after rTMS or ATX treatment in ADHD patients. However, the expression of miRNA-107 showed no significant difference between ADHD patients and healthy children or before and after rTMS (or ATX treatment). These results suggest that serum miRNA-let-7d may serve as a potential diagnostic and therapeutic biomarker for children with ADHD.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Cao P,Wang L,Cheng Q,Sun X,Kang Q,Dai L,Zhou X,Song Zdoi
10.1016/j.psychres.2019.02.037subject
Has Abstractpub_date
2019-04-01 00:00:00pages
189-194eissn
0165-1781issn
1872-7123pii
S0165-1781(18)31761-Xjournal_volume
274pub_type
杂志文章,随机对照试验abstract：:The present study sought to identify factors associated with the onset of a manic or hypomanic episode during the month following a new antidepressant therapy in depressed bipolar patients. Patients receiving mood stabilizers for ≥3 months were screened from 400 French centers and were assessed for a 4-week period fol...
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