Abstract：
:Although deep grey matter (GM) involvement in multiple sclerosis (MS) is well documented, in-vivo multi-parameter magnetic resonance imaging (MRI) studies and association with detailed cognitive measures are limited. We investigated volumetric, diffusion and perfusion metrics in thalamus, hippocampus, putamen, caudate nucleus and globus pallidum, and neuropsychological measures, spanning 4 cognitive domains, in 60 relapsing-remitting MS patients (RRMS) (mean disease duration of 5.1 years, median EDSS of 1.5) and 30 healthy controls. There was significantly reduced volume of thalamus, hippocampus and putamen in the RRMS patients, but no diffusion or perfusion changes in these structures. Decreased volume in these deep GM volumes in RRMS patients was associated with a modest reduction in cognitive performance, particularly information processing speed, consistent with a subtle disruption of distributed networks, that subserve cognition, in these patients. Future longitudinal studies are needed to elucidate the influence of deep GM changes on the evolution of cognitive deficits in MS.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Debernard L,Melzer TR,Alla S,Eagle J,Van Stockum S,Graham C,Osborne JR,Dalrymple-Alford JC,Miller DH,Mason DFdoi
10.1016/j.pscychresns.2015.10.004subject
Has Abstractpub_date
2015-12-30 00:00:00pages
352-61issue
3eissn
0165-1781issn
1872-7123pii
S0925-4927(15)30116-5journal_volume
234pub_type
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