Abstract:
:We investigated the blood levels of mixed-lineage leukemia 1 (MLL1) mRNA and BDNF (brain derived neurotrophic factor) exon IV promoter on histone Histone 3 lysine 4 trimethylation (H3K4me3) in peripheral blood of patients with schizophrenia and controls. Over one year, 36 patients with schizophrenia and 32 controls were recruited. Psychiatric diagnoses were made based on DSM-IV criteria. Higher blood MLL1 mRNA and BDNF exon IV promoter on H3K4me3 levels were noted in patients with schizophrenia than in controls. The results showed that blood MLL1 mRNA and BDNF exon IV on H3K4me3 levels might be involved in the psychopathology of schizophrenia.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Huang TL,Lin CC,Chen RF,Lee CTdoi
10.1016/j.psychres.2016.06.010subject
Has Abstractpub_date
2016-09-30 00:00:00pages
207-9eissn
0165-1781issn
1872-7123pii
S0165-1781(15)30834-9journal_volume
243pub_type
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