Higher blood MLL1 mRNA and BDNF promoter IV on histone H3K4me3 levels in patients with schizophrenia.

Abstract:

:We investigated the blood levels of mixed-lineage leukemia 1 (MLL1) mRNA and BDNF (brain derived neurotrophic factor) exon IV promoter on histone Histone 3 lysine 4 trimethylation (H3K4me3) in peripheral blood of patients with schizophrenia and controls. Over one year, 36 patients with schizophrenia and 32 controls were recruited. Psychiatric diagnoses were made based on DSM-IV criteria. Higher blood MLL1 mRNA and BDNF exon IV promoter on H3K4me3 levels were noted in patients with schizophrenia than in controls. The results showed that blood MLL1 mRNA and BDNF exon IV on H3K4me3 levels might be involved in the psychopathology of schizophrenia.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Huang TL,Lin CC,Chen RF,Lee CT

doi

10.1016/j.psychres.2016.06.010

subject

Has Abstract

pub_date

2016-09-30 00:00:00

pages

207-9

eissn

0165-1781

issn

1872-7123

pii

S0165-1781(15)30834-9

journal_volume

243

pub_type

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