Abstract：
:The amygdala and the limbic system are important in inducing a fear reaction; if this "fear network" is involved in panic disorder, panic patients might be more sensitive to fear stimuli than healthy subjects. We compared the startle response with an aversive stimulus in a sample of 29 patients with panic disorder and a sample of 29 healthy controls. The intensity of the startle response, induced by a series of aversive loud (100 dB) sounds, was measured by skin conductance recording in each subject. No statistically significant differences between the two groups were found in either the baseline level of skin conductance or in the response to the stimuli. Nonetheless, panic patients reported significantly higher levels of baseline anxiety measured by the State-Trait Anxiety Inventory. In conclusion, our data do not support the hypothesis that patients with panic disorder are characterised by a hyperreactivity, as measured by the skin conductance response, to fearful sudden stimuli or, at least, to those delivered to the auditory system.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Favaron E,Bellodi L,Biffi S,Vanni G,Zorzi C,Liperi L,Perna Gdoi
10.1016/j.psychres.2009.04.020subject
Has Abstractpub_date
2010-04-30 00:00:00pages
254-6issue
2-3eissn
0165-1781issn
1872-7123pii
S0165-1781(09)00176-0journal_volume
176pub_type
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