High-dose naloxone affects task performance in normal subjects.

Abstract:

:Increasing intravenous doses of naloxone (0.3 mg/kg, 1 mg/kg, and 2 mg/kg) were administered to normal subjects. Naloxone at 2 mg/kg, but not at lower doses, impaired aspects of memory as measured by a verbal learning task which assessed the direct free recall and recognition of presented versus non-presented words of a single category (effortful processing) and the monitoring of the frequency of such presentations (automatic processing). At the same time "working" memory was left unaffected. The results suggest a role for the opioid system in some memory processes in man.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Cohen RM,Cohen MR,Weingartner H,Pickar D,Murphy DL

doi

10.1016/0165-1781(83)90100-2

subject

Has Abstract

pub_date

1983-02-01 00:00:00

pages

127-36

issue

2

eissn

0165-1781

issn

1872-7123

pii

0165-1781(83)90100-2

journal_volume

8

pub_type

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