Association between cognitive performance and striatal dopamine binding is higher in timing and motor tasks in patients with schizophrenia.

Abstract:

:The basal ganglia have received increasing attention with regard to their role in time pacing, motor function and other components of cognition. The aim of this study was to test whether the finer the motor activity and/or time perception performance were, the higher the striatal dopamine D(2) binding would be. Single photon emission computed tomography (SPECT) with [(123)I]iodobenzamide (IBZM) was performed to measure striatal D(2) receptor densities. A battery of neuropsychological tests, including the Wisconsin Card Sorting Test (WCST), the finger tapping test (FTT), and an attention test, was performed by patients with schizophrenia. Results indicated a strong correlation between the FTT score and striatal D(2) receptor binding. Neuroleptic dosage plays an important role in the relationship between cognitive tasks and striatal dopamine receptor densities. In addition, the striatal D(2) receptor density is more significantly correlated with attentional tests that consider the time effect than those that do not. Among the three tests performed, the WCST was least significantly correlated with striatal D(2) receptor densities. A decrease in striatal dopamine D(2) receptor density seems to be associated with impaired performance on optimal timing tasks and motor processing in patients with schizophrenia.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Yang YK,Yeh TL,Chiu NT,Lee IH,Chen PS,Lee LC,Jeffries KJ

doi

10.1016/j.pscychresns.2003.07.002

subject

Has Abstract

pub_date

2004-09-15 00:00:00

pages

209-16

issue

3

eissn

0165-1781

issn

1872-7123

pii

S0925492704000502

journal_volume

131

pub_type

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