Abstract：
:We wished to determine whether decreases in prefrontal glutamate concentrations occur in offspring of parents with bipolar disorder with and at high risk for mania. Sixty children and adolescents, 9-18 years old, of parents with bipolar I or II disorder (20 offspring with established history of mania, "BD", 20 offspring with symptoms subsyndromal to mania, "SS", and 20 healthy controls "HC") were examined using proton magnetic resonance spectroscopy at 3T to study glutamatergic metabolite concentrations in the anterior cingulate cortex (ACC). A signal for reductions in absolute glutamate concentrations in the ACC was seen in the BD compared with HC and SS groups. No other statistically significant differences among groups were found. Offspring of parents with BD with prior histories of mania may have disruptions in glutamatergic function compared with HC or children at risk for BD who have not yet developed mania. Longitudinal studies are necessary to confirm whether prefrontal glutamate decreases only after the onset of full mania.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Singh M,Spielman D,Adleman N,Alegria D,Howe M,Reiss A,Chang Kdoi
10.1016/j.pscychresns.2010.01.003subject
Has Abstractpub_date
2010-05-30 00:00:00pages
165-71issue
2eissn
0165-1781issn
1872-7123pii
S0925-4927(10)00028-4journal_volume
182pub_type
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