当前位置： SCI文献检索 > PSYCHIATRY RESEARCH期刊下所有文献 > Neuropsychological correlates of P300 abnormalities in patients with schizophrenia and obsessive-compulsive disorder.

Neuropsychological correlates of P300 abnormalities in patients with schizophrenia and obsessive-compulsive disorder.

Abstract：

:The cognitive significance of P300 abnormalities in schizophrenia and obsessive-compulsive disorder (OCD) was investigated. P300 was measured by an auditory oddball paradigm, in which a series of standard tones (1000 Hz) and target tones (1500 Hz) were presented. The subject's task was to count the number of the presented target tones. Cognitive functions were evaluated by neuropsychological tests, which were chosen to be sensitive to frontal and temporal dysfunction. Twenty-two schizophrenic patients, 19 OCD patients and 21 healthy controls participated. Event-related potentials measured at 15 electrode sites, which consisted of five levels on the left-right dimension and three levels on the anterior-posterior dimension, were included in the statistical analysis. P300 amplitudes on all 15 electrode sites were significantly smaller in schizophrenic and OCD patients than in the controls. Schizophrenic patients performed poorly on almost all neuropsychological tests, while OCD patients showed impaired performance on the Rey-Osterrieth Complex Figure Test and on a controlled oral word association test. In schizophrenic patients, P300 amplitude was associated with performance on verbal memory and learning by the Luria-Nebraska Neuropsychological Battery, while for OCD patients, P300 amplitude was related to the Trail Making Test, Part B response time. These results indicate that schizophrenic patients have generalized cognitive impairments, which are substrated by a wide range of cortical dysfunctions. The major cognitive deficits observed in OCD patients were impairments of controlled attention and self-guided, flexible behavior, which are mediated by the fronto-striatal system. The neurophysiological mechanisms underlying P300 abnormalities observed in schizophrenic and OCD patients are discussed.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Kim MS,Kang SS,Youn T,Kang DH,Kim JJ,Kwon JS

doi

10.1016/s0925-4927(03)00045-3

subject

Has Abstract

pub_date

2003-06-30 00:00:00

pages

109-23

issue

2

eissn

0165-1781

issn

1872-7123

pii

S0925492703000453

journal_volume

123

pub_type

杂志文章

相关文献

PSYCHIATRY RESEARCH文献大全
  • Risk indicators for post-traumatic stress disorder in adolescents exposed to the 5.12 Wenchuan earthquake in China.

    abstract：:In Chinese adolescents exposed to the Wenchuan earthquake, we used the Children's Revised Impact of Event Scale (CRIES) as the screening tool, and Post-traumatic Cognitions Inventory (PTCI) and the Social Support Rating Scale (SSRS) were used to assess the cognitive status and their social supports, to evaluate the pr...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2010.12.016

    authors： Ma X,Liu X,Hu X,Qiu C,Wang Y,Huang Y,Wang Q,Zhang W,Li T

    更新日期：2011-10-30 00:00:00

  • High Intensity Interval training (HIIT) for people with severe mental illness: A systematic review & meta-analysis of intervention studies- considering diverse approaches for mental and physical recovery.

    abstract：:There is a mortality gap of 15 to 20 years for people with severe mental illness (SMI - psychotic spectrum, bipolar, major depressive disorders). Modifiable risk factors include inactivity and low cardiorespiratory fitness (CRF). Exercise can improve mental and physical outcomes; optimal type and intensity of exercise...

    journal_title：Psychiatry research

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.psychres.2019.112601

    authors： Korman N,Armour M,Chapman J,Rosenbaum S,Kisely S,Suetani S,Firth J,Siskind D

    更新日期：2020-02-01 00:00:00

  • Intact perception of coherent motion, dynamic rigid form, and biological motion in chronic schizophrenia.

    abstract：BACKGROUND:Prior studies have documented biological motion perception deficits in schizophrenia, but it remains unclear whether the impairments arise from poor social cognition, perceptual organization, basic motion processing, or sustained attention/motivation. To address the issue, we had 24 chronic schizophrenia pat...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2018.06.052

    authors： Keane BP,Peng Y,Demmin D,Silverstein SM,Lu H

    更新日期：2018-10-01 00:00:00

  • Effect of clozapine on white matter integrity in patients with schizophrenia: a diffusion tensor imaging study.

    abstract：:Several diffusion tensor imaging (DTI) studies have reported disturbed white matter integrity in various brain regions in patients with schizophrenia, whereas only a few studied the effect of antipsychotics on DTI measures. The aim of this study was to investigate the effect of 12 weeks of clozapine treatment on DTI f...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.pscychresns.2014.06.001

    authors： Ozcelik-Eroglu E,Ertugrul A,Oguz KK,Has AC,Karahan S,Yazici MK

    更新日期：2014-09-30 00:00:00

  • Plasma measures of beta-endorphin/beta-lipotropin-like immunoreactivity in chronic pain syndrome and psychiatric subjects.

    abstract：:This study compared basal concentrations of plasma beta-endorphin/beta-lipotropin-like immunoreactivity and dexamethasone suppression of cortisol in seven chronic pain patients, seven psychiatric disorder patients, and seven normal volunteers. Pain patients and psychiatric patients showed significantly higher basal co...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/0165-1781(83)90005-7

    authors： Atkinson JH,Kremer EF,Risch SC,Morgan CD,Azad RF,Ehlers CL,Bloom FE

    更新日期：1983-08-01 00:00:00

  • Predicting Alzheimer's disease based on survival data and longitudinally measured performance on cognitive and functional scales.

    abstract：:This study assessed how well longitudinally taken cognitive and functional scales from people with mild cognitive impairment (MCI) predict conversion to Alzheimer's disease (AD). Participants were individuals with baseline MCI from the Alzheimer's Disease Neuroimaging Initiative. Scales included the Alzheimer Disease ...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2020.113201

    authors： Wu Y,Zhang X,He Y,Cui J,Ge X,Han H,Luo Y,Liu L,Wang X,Yu H,Alzheimer's Disease Neuroimaging Initiative.

    更新日期：2020-09-01 00:00:00

  • TPH2 gene variants and anxiety during alcohol detoxification outcome.

    abstract：:Clinical outcome of alcoholism may be partly under genetic control. The serotonergic system is involved in alcohol intake, and it has been widely investigated in alcohol dependence. Recently, attention has been focused on the neuronal tryptophan hydroxylase 2 gene (TPH2). TPH2 variants have been consistently associate...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2007.12.006

    authors： Serretti A,Liappas I,Mandelli L,Albani D,Forloni G,Malitas P,Piperi C,Politis A,Tzavellas EO,Papadopoulou-Daifoti Z,Zisaki A,Prato F,Batelli S,Polito L,De Ronchi D,Kalofoutis A

    更新日期：2009-05-15 00:00:00

  • Alterations in hippocampal connectivity across the psychosis dimension.

    abstract：:Recent evidence demonstrates that hippocampal hyperactivity helps mediate psychosis. Using resting state functional magnetic resonance imaging (rsfMRI), we examined hippocampal connectivity alterations in individuals with psychosis (PS) versus healthy controls (HC). Because of its putative greater involvement in psych...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.pscychresns.2015.06.004

    authors： Samudra N,Ivleva EI,Hubbard NA,Rypma B,Sweeney JA,Clementz BA,Keshavan MS,Pearlson GD,Tamminga CA

    更新日期：2015-08-30 00:00:00

  • Inside the mind of poor Tom--A multidimensional approach to determine causes for redundant clothing in patients with schizophrenia.

    abstract：:Redundant clothing (RC) is a readily observable feature of schizophrenia. While abnormal thermoregulation, thyroid dysfunction and autonomic dysregulation have been postulated to account for RC, no identified factor yet conclusively explains this enigmatic behaviour. This study attempted to determine the cause(s) of R...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2015.03.029

    authors： Mahintamani T,Ram D,Mitra S

    更新日期：2015-06-30 00:00:00

  • Lateral visual field stimulation reveals extrastriate cortical activation in the contralateral hemisphere: an fMRI study.

    abstract：:We examined whether lateral visual field stimulation (LSTM) could activate contralateral extrastriate cortical areas as predicted by a large experimental literature. We asked seven unscreened, control subjects to wear glasses designed to allow vision out of either the left (LVF) or right lateral visual field (RVF) dep...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.pscychresns.2004.01.002

    authors： Schiffer F,Mottaghy FM,Pandey Vimal RL,Renshaw PF,Cowan R,Pascual-Leone A,Teicher M,Valente E,Rohan M

    更新日期：2004-05-30 00:00:00

  • Personality disorders and perceived stress in major depressive disorder.

    abstract：:The investigation of comorbidity between major depressive disorder (MDD) and personality disorders (PDs) has attracted considerable interest. Whereas some studies found that the presence of PDs has adverse effects on the course and treatment of MDD, others have failed to demonstrate this link. These inconsistent findi...

    journal_title：Psychiatry research

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.psychres.2007.06.014

    authors： Candrian M,Schwartz F,Farabaugh A,Perlis RH,Ehlert U,Fava M

    更新日期：2008-08-15 00:00:00

  • No association between bipolar affective disorder and a serotonin receptor (5-HT2A) polymorphism.

    abstract：:The serotonergic system is implicated in the pathogenesis of affective disorders. In particular, the role of the postsynaptic 5-hydroxytryptamine (serotonin) type 2 receptor (5-HT2) has been documented by several studies. The 5-HT2A receptor gene located on chromosome 13 (13q14-21) can be considered a candidate gene f...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/s0165-1781(97)03028-x

    authors： Mahieu B,Souery D,Lipp O,Mendelbaum K,Verheyen G,De Maertelaer V,Van Broeckhoven C,Mendlewicz J

    更新日期：1997-05-05 00:00:00

  • Double jeopardy in the United States: Early onset bipolar disorder and treatment delay.

    abstract：BACKGROUND:Evidence is emerging that early onset bipolar disorder and the duration of the delay to first treatment are both risk factors for poor treatment outcome. We report on the incidence and implications of these two risk factors in patients from the United States (US) versus Europe. METHODS:Age of onset and age ...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2020.113274

    authors： Post RM,Altshuler LL,Kupka R,McElroy SL,Frye MA,Rowe M,Grunze H,Suppes T,Keck PE Jr,Nolen WA

    更新日期：2020-10-01 00:00:00

  • Can sleep disturbance in depression predict repetitive transcranial magnetic stimulation (rTMS) treatment response?

    abstract：:Treatment for depression is not effective in all patients and it is therefore important to identify factors that can be used to tailor treatments. One potential factor is insomnia. Several repetitive transcranial magnetic stimulation (rTMS) studies have reported on this symptom, however, they did not take into account...

    journal_title：Psychiatry research

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.psychres.2013.04.028

    authors： Lowe A,Rajaratnam SM,Hoy K,Taffe J,Fitzgerald PB

    更新日期：2013-11-30 00:00:00

  • Neuroimaging of hallucinations: a review of the literature.

    abstract：:While hallucinations have been described for over two millennia, their cause remains unclear. Brain-based models suggest that abnormal cerebral excitation and a lack of normal cerebral inhibition may play primary roles, but evaluation of these hypotheses has been hampered by difficulty in studying the hallucinatory st...

    journal_title：Psychiatry research

    pub_type： 杂志文章,评审

    doi：10.1016/s0925-4927(99)00041-4

    authors： Weiss AP,Heckers S

    更新日期：1999-12-20 00:00:00

  • The 35% CO2 challenge test in patients with social phobia.

    abstract：:Panic disorder (PD) and social phobia (SP) share many clinical, demographic and biological characteristics. To investigate the relationships between the two disorders, the responses to inhalation of a 35% carbon-dioxide (CO2) and 65% oxygen (O2) gas mixture were assessed. Sixteen patients with PD, 16 patients with SP,...

    journal_title：Psychiatry research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0165-1781(97)00038-3

    authors： Caldirola D,Perna G,Arancio C,Bertani A,Bellodi L

    更新日期：1997-06-16 00:00:00

  • Course of pathological gambling symptoms and reliability of the Lifetime Gambling History measure.

    abstract：:The DSM-IV describes pathological gambling as a chronic condition with an insidious course. However, several extant studies characterize pathological and problem gambling as fluctuating over time. The present analyses expand on previous reports by evaluating changes in pathological gambling symptoms across the lifetim...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2006.05.015

    authors： Sartor CE,Scherrer JF,Shah KR,Xian H,Volberg R,Eisen SA

    更新日期：2007-07-30 00:00:00

  • Psychomotor changes in melancholic and atypical depression: unipolar and bipolar-II subtypes.

    abstract：:Psychomotor changes are reported to be 'nearly always present' in the melancholic subtype of major depressive episode (MDE) in DSM-IV-TR, and are believed by some researchers to be markers of melancholia. The aim of this study was to compare melancholic and atypical forms of MDE and to determine whether psychomotor ch...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/s0165-1781(02)00241-x

    authors： Benazzi F

    更新日期：2002-11-15 00:00:00

  • Emotional exhaustion and its relationship with suicide risk in emergency responders.

    abstract：:The purpose of the current study was to evaluate the relationship between emotional exhaustion and suicide risk in emergency responders. Participants included 643 actively employed emergency responders who responded to an online research based survey. Participants were administered the Maslach Burnout Inventory (MBI; ...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2020.113379

    authors： Edwards DL,Wilkerson ND

    更新日期：2020-11-01 00:00:00

  • Associations of beta-endorphin with HVA and MHPG in the plasma of prepubertal boys: effects of familial drug abuse and antisocial personality disorder liability.

    abstract：:It is well-established that the secretion of the opioid neuropeptide beta-endorphin is perturbed by the administration of various drugs of abuse. Several investigators have speculated that variations in beta-endorphin secretory regulation may precede the development of a substance use disorder, and thus be a component...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/0165-1781(96)02880-6

    authors： Moss HB,Yao JK

    更新日期：1996-06-01 00:00:00

  • Repeated administration of the combined dexamethasone-human corticotropin releasing hormone stimulation test during treatment of depression.

    abstract：:Human corticotropin releasing hormone (h-CRH) was administered to 14 patients with major depression, after premedication with an overnight dose of 1.5 mg dexamethasone. Cortisol response, expressed as area under the time course curve (AUC), was significantly higher in the 14 patients than in a group of 13 age-matched ...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/0165-1781(91)90041-m

    authors： Holsboer-Trachsler E,Stohler R,Hatzinger M

    更新日期：1991-08-01 00:00:00

  • DNA methylation and gene expression of the chemokine (C-X-C motif) ligand 1 in patients with deficit and non-deficit schizophrenia.

    abstract：:This study detected the differences in gene expression and DNA methylation of CpG sites in CXCL1 gene and further investigated their associations with clinical symptoms in deficit schizophrenia (DS) and non-deficit schizophrenia (NDS). Pyrosequencing and RT-qPCR were separately used to determine DNA methylation and mR...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2018.06.067

    authors： Zhou C,Chen J,Tang X,Feng X,Yu M,Sha W,Wang X,Zhang X,Yi H,Zhang X

    更新日期：2018-10-01 00:00:00

  • Stress reactivity links childhood trauma exposure to an admixture of depressive, anxiety, and psychosis symptoms.

    abstract：:Childhood trauma exposure has been associated with a clinically relevant mixed phenotype of psychopathology composed of depressive, anxiety, and psychosis symptoms, across healthy and clinical samples. Altered stress-reactivity after exposure to childhood trauma may be a plausible underlying mechanism explaining this ...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2017.12.012

    authors： van Nierop M,Lecei A,Myin-Germeys I,Collip D,Viechtbauer W,Jacobs N,Derom C,Thiery E,van Os J,van Winkel R

    更新日期：2018-02-01 00:00:00

  • Intravenous diazepam fails to change growth hormone and cortisol secretion in humans.

    abstract：:Some, but not all studies have reported that a single dose of benzodiazepine affects growth hormone (GH) and cortisol secretion in healthy volunteers. The majority of studies that found GH elevations after benzodiazepine administration did not use placebo trials. The present placebo-controlled investigation determined...

    journal_title：Psychiatry research

    pub_type： 临床试验,杂志文章

    doi：10.1016/0165-1781(86)90014-4

    authors： Breier A,Charney DS,Heninger GR

    更新日期：1986-08-01 00:00:00

  • Amygdala reactivity to faces at varying intensities of threat in generalized social phobia: an event-related functional MRI study.

    abstract：:Using functional magnetic resonance imaging, we measured amygdala reactivity to faces varying on threat intensity in patients with generalized social phobia (GSP) and healthy controls. GSP patients exhibited greater amygdala reactivity to threat faces at high and moderate intensities. More subtle displays of social th...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.pscychresns.2010.05.001

    authors： Klumpp H,Angstadt M,Nathan PJ,Phan KL

    更新日期：2010-08-30 00:00:00

  • Facial trustworthiness perception bias elevated in individuals with PTSD compared to trauma exposed controls.

    abstract：:Posttraumatic stress disorder (PTSD) research has focused largely on fear processing. However, interpersonal trauma exposure can also impact interpersonal functioning and the perception of the trustworthiness of others. The present study examined facial perceptions of fearfulness and trustworthiness in individuals wit...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2016.01.056

    authors： Fertuck EA,Tsoi F,Grinband J,Ruglass L,Melara R,Hien DA

    更新日期：2016-03-30 00:00:00

  • Dissociation of explicit and implicit measures of the behavioral inhibition and activation system in borderline personality disorder.

    abstract：:Patients with borderline personality disorder (BPD) suffer from various impairments in emotional functioning such as affective instability, inappropriate anger and unstable relationships. These deficits may influence two fundamental motivational systems, the behavioral inhibition system (BIS) and behavioral activation...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2014.04.027

    authors： Kobeleva X,Seidel EM,Kohler C,Schneider F,Habel U,Derntl B

    更新日期：2014-08-15 00:00:00

  • Variations in [3H]imipramine and 5-HT2A but not [3H]paroxetine binding sites in suicide brains.

    abstract：:Both the [3H]imipramine and [3H]paroxetine binding sites and the 5-HT2A receptor were simultaneously determined in frontal cortex, cingulate cortex, hippocampus and amygdala from 17 control subjects and 17 depressed suicide victims. A significant decrease in the maximum binding (Bmax) of [3H]imipramine was observed in...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/s0925-4927(98)00015-8

    authors： Rosel P,Arranz B,Vallejo J,Oros M,Crespo JM,Menchon JM,Navarro MA

    更新日期：1998-06-30 00:00:00

  • Impaired face recognition is associated with social inhibition.

    abstract：:Face recognition is fundamental to successful social interaction. Individuals with deficits in face recognition are likely to have social functioning impairments that may lead to heightened risk for social anxiety. A critical component of social interaction is how quickly a face is learned during initial exposure to a...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2015.12.035

    authors： Avery SN,VanDerKlok RM,Heckers S,Blackford JU

    更新日期：2016-02-28 00:00:00

  • Paliperidone is associated with reduced risk of severe hepatic outcome in patients with schizophrenia and viral hepatitis: A nationwide population-based cohort study.

    abstract：OBJECTIVE:Paliperidone, a second-generation antipsychotic, has been found to have minimal hepatotoxicity in patients with schizophrenia. However, long-term hepatic outcome in patients with schizophrenia and viral hepatitis remains unclear. METHODS:Data obtained from the Taiwan National Health Insurance Research Databa...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2019.112597

    authors： Chang CH,Lane HY,Liu CY,Chen SJ,Lin CH

    更新日期：2019-11-01 00:00:00