Abstract：
:The cognitive effects of the specific norepinephrine (NE) uptake inhibitor desmethylimipramine (DMI) were examined in normal subjects. Although there were no differences in performance on drug compared to placebo treatment, there was an improvement in cognition 1 week after the drug had been discontinued. On DMI, there was evidence for increased noradrenergic activity, which was uncorrelated with measures of learning and memory. An improvement in mood during drug withdrawal was uncorrelated with the cognitive enhancement. It was concluded that the discontinuation of DMI, a drug which primarily affects NE uptake, improves several measures of learning and memory. Drug effects on cognition may be most pronounced during the withdrawal period.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Ross RJ,Smallberg S,Weingartner Hdoi
10.1016/0165-1781(84)90141-0subject
Has Abstractpub_date
1984-05-01 00:00:00pages
89-97issue
1eissn
0165-1781issn
1872-7123pii
0165-1781(84)90141-0journal_volume
12pub_type
临床试验,杂志文章abstract：:Dysthymic disorder is a chronic depressive condition with considerable psychosocial impairment. Even if DD patients respond to various antidepressant medications, there has been little systematic study on antidepressant-refractory DD. Only a few trials have evaluated the effects of treatment on psychosocial functionin...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0165-1781(02)00188-9
更新日期：2002-10-10 00:00:00
abstract：:Depression is a common illness which tends to have a relapsing progression. Revealing vulnerability factors is an important step towards improved treatment and prevention. Previous studies of individuals in remission indicate that inhibitory control is more strongly impaired than other cognitive functions. Studies hav...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.11.038
更新日期：2016-01-30 00:00:00
abstract：:Earlier (Bolinskey et al., 2015), we reported that psychometrically identified schizotypes displayed greater symptom levels and higher incidences of schizophrenia spectrum (schizotypal, schizoid, paranoid, and avoidant) personality disorders (PDs). In this study, 49 schizotypes and 39 matched controls participated in ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.03.014
更新日期：2017-06-01 00:00:00
abstract：:Neuroimaging studies indicate diminished lateralisation of cerebral activity during motor tasks and language processing in schizophrenia. Some evidence also indicates that decreased lateralisation is accompanied by more diffuse intra-hemispheric activation, suggesting that diminished lateralisation might be part of a ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2009.04.004
更新日期：2009-10-30 00:00:00
abstract：:Psychosis induced by the use of amphetamine or methamphetamine leads to dramatic symptoms and frequent readmissions and poses diagnostic challenges. Earlier studies have often relied on history taking and/or urine samples to reveal drug use. The aim of this study was to compare the psychotic symptoms of two groups: (1...
journal_title：Psychiatry research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.psychres.2012.09.023
更新日期：2013-03-30 00:00:00
abstract：:The distribution of platelet monoamine oxidase (MAO) activity is examined in a large cohort of 18-year-olds from a college setting. A mixture of three distributions is needed to describe the data, even when a power transformation is used to remove skewness in the distribution. This is compatible with MAO activity bein...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(82)90069-5
更新日期：1982-12-01 00:00:00
abstract：BACKGROUND:The current COVID-19 pandemic and the consequent containment measures are leading to increasing mental health issues both in psychiatric patients and general population. OBJECTIVE:We aimed to compare the number and characteristics of emergency psychiatric consultations during the phase 1 of lockdown with re...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113463
更新日期：2020-11-01 00:00:00
abstract：:The heritability of some individual depressive symptoms has been well established. However, the causal genes related to individual depressive symptoms and genetic effects on the courses of individual depressive symptoms are still unclear. We examined these issues in 241 Korean patients who met the DSM-IV-TR criteria f...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/j.psychres.2011.12.037
更新日期：2012-08-15 00:00:00
abstract：:Psychosis is associated with low-grade inflammation as measured by high-sensitivity C-reactive protein (hs-CRP), a risk factor for cardiovascular events and mortality in the general population. We investigated the relationship between hs-CRP and anthropometric and metabolic changes in first-episode psychosis (FEP) dur...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.10.022
更新日期：2018-12-01 00:00:00
abstract：:We investigated whether symptom overreporting affects the dose-response relationship between self-reported abuse severity and psychiatric symptoms in two samples. The first sample (N=599) consisted of adults who had previously reported to a public commission that they had been witnesses to or victims of childhood sexu...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.03.018
更新日期：2014-07-30 00:00:00
abstract：:This 5-week, randomized, double-blind, placebo-controlled trial investigated the efficacy and tolerability of high frequency repetitive transcranial magnetic stimulation (rTMS) directed to the left prefrontal cortex in drug-resistant depressed patients. Fifty-four patients were randomly assigned to receive 10 daily ap...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2005.06.008
更新日期：2005-11-15 00:00:00
abstract：:The aim of the current study was to explore the associations between changes in the number of binges, physical activity participation, physical fitness, physical self-perception and quality of life following a 6-month physical activity counseling and cognitive behavioral program in patients with binge eating disorder ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.05.016
更新日期：2014-10-30 00:00:00
abstract：:We examined the relationship between the cortisol response to stress and aggression in patients with attention deficit hyperactivity disorder (ADHD). Based on a report stating that only some of the patients with ADHD retain their hypothalamic-pituitary-adrenal axis reactivity to stress, we separately analyzed the rela...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.04.001
更新日期：2007-09-30 00:00:00
abstract：:The aim of the present work was to investigate if insomnia in late pregnancy is a risk factor for postpartum depressive symptomatology/postpartum depression (PPD). 581 women in their last trimester of pregnancy answered questions/questionnaires about lifetime history of insomnia, current sleep perception, current mood...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.06.029
更新日期：2011-04-30 00:00:00
abstract：:Two groups of 32 rats were challenged in a well-habituated environment with haloperidol (0.5 mg/kg), haloperidol (0.1 mg/kg), domperidone (0.1 mg/kg), or saline to study the effect of these drugs on defecation--an index of emotionality--and voluntary movements in the 2 hours after the injection. The haloperidol-treate...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(93)90053-j
更新日期：1993-04-01 00:00:00
abstract：:This study examined by questionnaire the prevalence of binge-eating and bulimia among 220 women at a school of nursing and 236 women at a junior college, all from 18 to 21 years old, in two different areas of Japan. Binge-eating more than once a week was found in 14 (6.5%) of the nursing school students and 21 (9.1%) ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(88)90071-6
更新日期：1988-11-01 00:00:00
abstract：:The orexigenic hormone ghrelin is involved in the regulation of food intake and energy balance. Previous findings suggest its involvement in the modulation of mesolimbic reward pathways, thus potentially being relevant in the pathophysiology of substance use disorders such as alcohol dependence. In the present study, ...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2018.12.095
更新日期：2019-02-01 00:00:00
abstract：:The authors administered the Tridimensional Personality Questionnaire (TPQ) on two occasions separated by more than 1 month to 30 patients with psychotic disorders to examine hypothesized relationships between affective symptomatology and the TPQ dimension Harm Avoidance. As predicted, changes in Harm Avoidance scores...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(95)02655-g
更新日期：1995-08-28 00:00:00
abstract：:The current study was the first one to reveal the contribution of DRD3 methylation to the risk of different (SCZ) subtypes. This study comprised a total of 30 paranoid (15 males and 15 females) and 29 undifferentiated (15 males and 14 females) SCZ patients and 26 age- and gender-matched controls. Our results showed a ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.08.032
更新日期：2014-12-30 00:00:00
abstract：:Cognitive empathy impairments have been linked to poor social functioning in schizophrenia. However, prior studies primarily used self-reported empathy measures developed decades ago that are not well-aligned with contemporary models of empathy. We evaluated empathy and its relationship to social functioning in schizo...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.08.054
更新日期：2014-09-04 00:00:00
abstract：:Children's mental health problems substantially impact their functioning. For clinically treated children and adolescents, we explored the impact of mental health treatment on functioning and identified predictors of functional improvement. Outpatient clinical data from a regional publicly funded specialist outpatient...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.01.093
更新日期：2019-03-01 00:00:00
abstract：:This study aimed to investigate whether cognitive impairment is more pronounced in people with treatment-resistant schizophrenia compared with those who respond well to first-line antipsychotic medication. Fifty-one patients with schizophrenia were assigned to one of three groups dependent on their clinical history: (...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.10.036
更新日期：2015-12-30 00:00:00
abstract：:Several neurophysiological indicators of abnormal sensory processing found in psychosis are also found in lower incidence in normal populations, particularly those at the age of risk for illness. One such parameter, gating of the auditory evoked potential, was evaluated in college students. Auditory stimuli were prese...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(86)90102-2
更新日期：1986-11-01 00:00:00
abstract：:Despite heritability estimates of 37-69%, research has identified few genetic risk variants for borderline personality disorder (BPD). The present collaborative candidate gene study of 987 BPD cases and 1110 healthy controls found an association between BPD and single nucleotide polymorphism rs12718541 in the dopa dec...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.06.031
更新日期：2014-11-30 00:00:00
abstract：:Schizophrenia is a chronic disorder that is usually characterized by relapses alternating with periods of full or partial remission. We examined whether combined therapy with a psychosocial intervention for relapse prevention (PIRP) and risperidone administered by long-acting injection (RLAI) would be more effective i...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/j.psychres.2008.06.043
更新日期：2010-02-28 00:00:00
abstract：:The interplay between Callous Unemotional Traits (CU) and Moral Disengagement (MD) was examined in a sample of 90 adolescents with Disruptive Behavior Disorders. Using a person-centered approach, three CU and MD configurations were identified, attesting the strong relationship between these two moral dimensions. Howev...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.08.043
更新日期：2017-12-01 00:00:00
abstract：:Obsessive-compulsive disorder (OCD) has been linked to a dysfunction of brain corticostriatal networks, although functional imaging studies of OCD rarely apply network-sensitive analysis methods. In this study, we compared a univariate and a multivariate analysis of PET data in OCD patients and healthy subjects; the l...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2006.03.002
更新日期：2006-10-30 00:00:00
abstract：:Neuroimaging in anorexia nervosa has revealed morphological and functional alterations, most of which are currently interpreted as consequences of the anorectic state that are reversible, at least partially, after weight gain. Enlargement of CSF spaces, mainly of cortical sulci, is evident on CT and MRI. This reversib...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/0165-1781(96)02990-3
更新日期：1996-04-16 00:00:00
abstract：:It has been shown that the dysfunction of N-methyl-d-asparate (NMDA) receptors-mediated neurotransmission plays a role in the pathophysiology of schizophrenia. Especially, GluN2B, a subunit of NMDA receptors, associated trafficking complex is altered in the prefrontal cortex of schizophrenia. The kinesin superfamily m...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.09.031
更新日期：2015-12-15 00:00:00
abstract：BACKGROUND:Several studies that have examined the full range of alcohol consumption have pointed to a possible non-linear association between alcohol use and the common mental disorders. Most of these studies are cross sectional and assessed psychiatric morbidity using non-specific instruments. Our aim was to investiga...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.05.049
更新日期：2016-09-30 00:00:00
