Abstract：
:The heritability of some individual depressive symptoms has been well established. However, the causal genes related to individual depressive symptoms and genetic effects on the courses of individual depressive symptoms are still unclear. We examined these issues in 241 Korean patients who met the DSM-IV-TR criteria for major depression. Patients entered a 12-week clinical trial with antidepressants. A total of 1399 single-nucleotide polymorphisms (SNPs) of 79 candidate genes were assessed. The rs557762 and the TT haplotype in the 11th haplotype block of the GRIA3 gene were associated with feelings of guilt in females. The GGCCGGGC haplotype in the first haplotype block of TPH1 was significantly associated with middle insomnia. The ACAG haplotype in the 13th haplotype block of the GRIK2 gene was associated with somatic anxiety. Moreover, the effect of the rs557762 on guilt significantly varied across times. Our results indicate that there are associations between particular gene polymorphisms and some individual depressive symptoms. These results could contribute to understanding the biological mechanisms of depression.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Myung W,Song J,Lim SW,Won HH,Kim S,Lee Y,Kang HS,Lee H,Kim JW,Carroll BJ,Kim DKdoi
10.1016/j.psychres.2011.12.037subject
Has Abstractpub_date
2012-08-15 00:00:00pages
400-6issue
3eissn
0165-1781issn
1872-7123pii
S0165-1781(11)00821-3journal_volume
198pub_type
临床试验,杂志文章abstract：:Eating disorders (EDs) are psychiatric disorders associated with high morbidity and mortality. It is well established that patients with anorexia nervosa (AN) have an increased risk of premature death, whereas mortality data are lacking for the other EDs. This study aimed to establish mortality rates in a sample of ED...
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journal_title：Psychiatry research
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1993-12-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.09.048
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.06.029
更新日期：2015-08-30 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.psychres.2013.07.016
更新日期：2013-12-15 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2014.06.001
更新日期：2014-09-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.01.083
更新日期：2019-03-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.06.028
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journal_title：Psychiatry research
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doi：10.1016/j.psychres.2012.03.033
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journal_title：Psychiatry research
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2015-12-15 00:00:00
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更新日期：2019-07-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2020-10-01 00:00:00
abstract：:Posttraumatic stress disorder (PTSD) research has focused largely on fear processing. However, interpersonal trauma exposure can also impact interpersonal functioning and the perception of the trustworthiness of others. The present study examined facial perceptions of fearfulness and trustworthiness in individuals wit...
journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2016-03-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2009-01-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2014.10.017
更新日期：2015-02-28 00:00:00
abstract：:Psychotic symptoms have been related to other coronavirus infections. We conducted a single-centre retrospective and observational study to describe new-onset psychotic episodes in COVID-19 patients. Ten patients infected by the novel coronavirus with psychotic symptoms and no previous history of psychosis were identi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113254
更新日期：2020-09-01 00:00:00
