Abstract:
:The association between orbital frontal cortex (OFC) volume and aggression was investigated in an at-risk psychiatric population. Forty-one psychiatric patients were referred for magnetic resonance imaging and a standardized psychometric assessment of aggression (Lifetime History of Aggression-Revised). Nineteen matched controls had lower levels of aggression and greater OFC volume, establishing the appropriateness of the psychiatric group for studying aggression pathophysiology. Consistent with study hypotheses, left OFC gray matter volume predicted 34% of the variance in self-reported aggression ratings. When impulsivity was not controlled for, left OFC gray matter only accounted for 26% of aggression variance, suggesting a complex relationship between impulsivity and OFC-aggression pathophysiology. Contrary to study hypotheses, right OFC gray matter volume did not predict degree of aggressive behavior. Current models do not account for lateralization, yet this may be quite important. Greater consideration should be given to laterality in OFC regulation of social/emotional behavior. Regulatory focus theory, positing two motivational systems, promotion and prevention, lateralized to the left and right hemispheres, respectively, may provide an explanatory framework for these results. Dysregulation of the left hemisphere 'promotion' motivational system may help to explain the aggressive behavior present in psychiatric populations.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Gansler DA,McLaughlin NC,Iguchi L,Jerram M,Moore DW,Bhadelia R,Fulwiler Cdoi
10.1016/j.pscychresns.2008.03.007subject
Has Abstractpub_date
2009-03-31 00:00:00pages
145-54issue
3eissn
0165-1781issn
1872-7123pii
S0925-4927(08)00052-8journal_volume
171pub_type
杂志文章abstract::We have previously reported decreased heart rate variability upon standing in panic disorder patients compared with controls. In this study, we extend our report to include patients with major depression (n = 19). Compared to normal controls (n = 20) and panic disorder patients (n = 30), there was no significant diffe...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(91)90104-w
更新日期:1991-04-01 00:00:00
abstract::The need for closure (NFC), a desire for a firm answer and less ambiguity, has a key role in cognitive flexibility in typical development (TD) populations. This study investigated this motivational construct and its relation to cognitive inflexibility in autism spectrum disorder (ASD). Compared with individuals with T...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.11.057
更新日期:2019-01-01 00:00:00
abstract::The processing of social stimuli generated by one's own voluntary behavior is an element of social adaptation. It is known that self-generated stimuli induce attenuated sensory experiences compared with externally generated stimuli. The present study aimed to examine this self-specific attenuation effect on early stim...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.12.037
更新日期:2019-01-01 00:00:00
abstract::We examined associations between social connections and non-suicidal self-injury (NSSI) among transgender/gender non-conforming (TGNC) youth. Data came from the 2016 Minnesota Student Survey (N = 2168). Logistic regression analyses determined connectedness factors associated with any past-year NSSI and repetitive NSSI...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.06.068
更新日期:2018-10-01 00:00:00
abstract::Proton magnetic resonance spectroscopy ((1)H MRS) has revealed biochemical alterations in various psychiatric disorders. Changes in brain metabolites may be caused not only by the disease's progression or response to treatment, but also by physiological variability. The aim of this study was to use (1)H MRS to assess ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2006.01.010
更新日期:2006-06-30 00:00:00
abstract::No differences in levels of type A monoamine oxidase (MAO) were observed in cultured human skin fibroblasts from nine patients with bipolar depressive illness as compared to 18 age-, sex-, and race-matched controls. All cells were biopsied and cultured under parallel conditions. Fibroblasts from monozygotic twins (thr...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(80)90022-0
更新日期:1980-07-01 00:00:00
abstract::Research on neurobiological impairments in clinical and genetic high risk for developing psychosis individuals (CHR) has identified several brain abnormalities that impact both brain structure and function. The current review will discuss research examining brain abnormalities in clinical and genetic high risk for psy...
journal_title:Psychiatry research
pub_type: 杂志文章,评审
doi:10.1016/j.psychres.2019.02.009
更新日期:2019-07-01 00:00:00
abstract::To date, there has been limited investigation identifying predictors of deliberate self-harm (DSH) among sexual minority adults. The present study examined the likelihood of DSH by sexual minority status as measured by self-reported sexual identity and sexual attraction in the National Epidemiologic Survey on Alcohol ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2020.112863
更新日期:2020-02-10 00:00:00
abstract::Low electro-oculographic (EOG) ratios have been reported in patients with seasonal affective disorder (SAD) during the winter. This study evaluated the effects of the changing seasons on EOG ratios in SAD patients. Sixteen outpatients with SAD and 16 age-, sex-, and medication-matched normal volunteers had EOG testing...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(95)02788-2
更新日期:1995-11-29 00:00:00
abstract::Growing evidence supports a continuum model of psychosis, with mild psychotic symptoms being frequently experienced by the general population. Moreover, believing in the continuum model correlates with less stigmatization of schizophrenia. This study explores whether continuum beliefs are a valid construct and develop...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.04.085
更新日期:2016-07-30 00:00:00
abstract::The aim of this study was to develop self-report and clinician-rated versions of an insight scale that would be easy to administer, sensitive to small changes, and inclusive of the core dimensions of clinical insight into psychosis. Ten-item self-report (VAGUS-SR) and five-item clinician-rated (VAGUS-CR) scales were d...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2014.08.005
更新日期:2014-12-30 00:00:00
abstract::Despite high rates of suicide in people who inject drugs, little is known about the risk factors for suicide related to childhood and family history in this population. We aimed to explore the relationship between the history of out-of-home care (OHC) and lifetime suicide attempts among people who inject opioids. Part...
journal_title:Psychiatry research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psychres.2019.112493
更新日期:2019-10-01 00:00:00
abstract::Cannabis use is considered an important risk factor for the development of psychotic illness and is associated with worse outcomes of the disorder. This study aimed to determine through a meta-analytic approach whether patients at the onset of schizophrenia with comorbid cannabis use (SCH CU+) show a different pattern...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2021.113731
更新日期:2021-01-16 00:00:00
abstract::To test the clinical efficacy of low dose fluphenazine decanoate (1.25 mg to 5.0 mg biweekly), we carried out two separate experiments: (1) an open trial in 57 schizophrenic outpatients, lasting 6 months; (2) a double-blind, placebo-controlled discontinuation study in a subgroup of patients who maintained good remissi...
journal_title:Psychiatry research
pub_type: 临床试验,杂志文章
doi:10.1016/0165-1781(79)90016-7
更新日期:1979-12-01 00:00:00
abstract::Although many treatments for Major Depressive Disorder (MDD) exist, only half of all patients respond to initial trial of pharmacotherapy and only a third will achieve remission with that trial. First-line therapies for the management of MDD include psychotherapy or pharmacotherapy, alone or in combination. Given the ...
journal_title:Psychiatry research
pub_type: 社论
doi:10.1016/S0165-1781(14)70001-0
更新日期:2014-12-01 00:00:00
abstract::Social cognition is impaired in schizophrenia, is relatively independent of purely neurocognitive domains such as attention and executive functioning, and may be the strongest predictor of functional outcome in this disease. Within a motivated reasoning framework, we tested the hypothesis that the anti-inflammatory Th...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2017.02.030
更新日期:2017-05-01 00:00:00
abstract::Following a drug-free placebo period lasting at least 1 week, 10 female and 11 male newly hospitalized schizophrenic patients received chlorpromazine (CPZ) 200 mg/day for 1 week and 400 mg/day the following week. Serum CPZ equivalent (CPZ-E) levels were measured at the end of each week of CPZ treatment with a radiorec...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(83)90001-x
更新日期:1983-08-01 00:00:00
abstract::The PHQ-9 has been found to be reliable and valid, but with both a single and two-factor structure suggested in the literature. This measure has not yet been subject to psychometric investigation using Mokken scale analysis. Confirmatory Factor Analysis (CFA) and Mokken analysis were performed on retrospective data fr...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.12.048
更新日期:2019-01-01 00:00:00
abstract::Children with prenatal exposure to cocaine are at higher risk for negative behavioral function and attention difficulties, and have demonstrated brain diffusion abnormalities in frontal white matter regions. However, brain regions beyond frontal and callosal areas have not been investigated using diffusion tensor imag...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2013.04.002
更新日期:2013-08-30 00:00:00
abstract::Mental disorders and sleep dysfunction are common among Chinese university students. This study aimed to evaluate a low cost scalable mindfulness intervention program to improve psychological health and sleep quality among Chinese university students. A randomized controlled trial with 101 university students (mean ag...
journal_title:Psychiatry research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psychres.2018.09.060
更新日期:2018-12-01 00:00:00
abstract::To adapt the Center for Epidemiologic Studies Depression Scale for use in non-psychiatric Spanish populations, a Spanish translation of the scale was interviewer-administered to 554 subjects aged 18-34 years (65.9% women) and the ratings so obtained were compared with the SCID-CV-based diagnoses of expert clinicians. ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2006.03.004
更新日期:2007-01-15 00:00:00
abstract::Trait anxiety, a personality dimension, has been characterized by functional consequences such as increased distractibility, attentional bias in favor of threat-related information and hyper-responsive amygdala. However, literature on the association between resting state brain functional connectivity, as studied usin...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2015.07.006
更新日期:2015-10-30 00:00:00
abstract::While research using Experience Sampling Methodology (ESM) suggests that, in general, contact with relatives or friends may be protective for psychotic experiences, contact with high-Expressed Emotion (high-EE) relatives can have adverse consequences for patients. This study investigated whether contact with high-EE r...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.08.060
更新日期:2016-11-30 00:00:00
abstract::Changes of serotonin2 (5HT2) receptors have been described in depression, and long-term antidepressant treatment has been shown to decrease the number of 5HT2 receptors. In this study, single photon emission computed tomography (SPECT), with 2-123I-ketanserin as a ligand, was used to investigate 5HT2 receptors in vivo...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0925-4927(92)90018-y
更新日期:1992-12-01 00:00:00
abstract::Emotion has been conceptualized as a dimensional construct, while the number of dimensions - two or three - has been debated. Research has consistently identified two dimensions - valence and arousal - though ample evidence exists that three dimensions are necessary to describe emotion. One proposed third dimension, i...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2013.11.007
更新日期:2014-02-28 00:00:00
abstract::Assaultive violence exposure during childhood is a significant risk factor for posttraumatic stress disorder (PTSD). The purpose of the present study was to characterize the relationships of assault and PTSD severity with the organization of large-scale networks identified during emotion processing. Adolescent girls a...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2013.06.003
更新日期:2013-12-30 00:00:00
abstract::Little is known about the relationship between precollege school bullying and murder-related psychological behaviors. The present study aims to examine that relationship in Chinese college students using a cross-sectional study. Self-report data were collected from 4034 college students in Anhui Province using a propo...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2019.112593
更新日期:2019-12-01 00:00:00
abstract::We assessed the course of psychiatric disorders in 23 cervical dystonia patients by using the structured clinical interview for DSM-IV and different rating scales. Patients were studied on two occasions 5 years apart. There were no differences in psychiatric disorders and severity of psychiatric symptoms between the t...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2015.07.076
更新日期:2015-09-30 00:00:00
abstract:BACKGROUND:The current COVID-19 pandemic and the consequent containment measures are leading to increasing mental health issues both in psychiatric patients and general population. OBJECTIVE:We aimed to compare the number and characteristics of emergency psychiatric consultations during the phase 1 of lockdown with re...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2020.113463
更新日期:2020-11-01 00:00:00
abstract::Easily available biomarkers for suicidality would be valuable for the identification of individuals at risk. Oxytocin has been shown to be associated with mental illness. We assessed basal oxytocin plasma levels of patients with (SA, n=41) and without (NSA, n=40) a 1-year history of attempted suicide. SA and NSA group...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2012.05.003
更新日期:2012-11-30 00:00:00