Abstract：
:Obsessive-compulsive disorder (OCD) has been linked to a dysfunction of brain corticostriatal networks, although functional imaging studies of OCD rarely apply network-sensitive analysis methods. In this study, we compared a univariate and a multivariate analysis of PET data in OCD patients and healthy subjects; the latter approach was considered more suitable for characterizing functional networks of brain activity. Although both methods suggested there was abnormal corticostriatal activity in OCD patients, the nature, extent and magnitude of this activity was clearly enhanced by the multivariate approach. Implications for the analysis of such studies are discussed.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Harrison BJ,Yücel M,Shaw M,Kyrios M,Maruff P,Brewer WJ,Purcell R,Velakoulis D,Strother SC,Scott AM,Nathan PJ,Pantelis Cdoi
10.1016/j.pscychresns.2006.03.002subject
Has Abstractpub_date
2006-10-30 00:00:00pages
227-31issue
2-3eissn
0165-1781issn
1872-7123pii
S0925-4927(06)00048-5journal_volume
147pub_type
杂志文章abstract：:Excessive interpersonal dependency has been described in depression and addictive disorders. Moreover, excessive dependency and suicidality are linked in psychiatric subjects, but their relationships have not been studied in specific addictions. Separate samples of female anorectic patients (n=150), female bulimic pat...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2004.06.022
更新日期：2005-11-15 00:00:00
abstract：:Seventeen psychiatric patients (11 with schizophrenia, 5 with other psychotic disorders, and 1 with obsessive-compulsive disorder) were examined by single photon emission computed tomography with 123I-iodobenzamide (IBZM) as tracer. Patients were treated with risperidone in two different dosage groups (3 mg and 8 mg) ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(96)02839-9
更新日期：1996-11-25 00:00:00
abstract：:In humans, there is an endogenous, near 24-h (i.e., circadian) variation in mood with the best mood occurring during the circadian day and the worst mood occurring during the circadian night. Only positive affect, and not negative affect, has been shown to contribute to this circadian rhythm. We discovered a sharp cir...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113337
更新日期：2020-11-01 00:00:00
abstract：:Objective measures of experimentally induced aggressiveness were evaluated in heroin-dependent patients (HDP), 15 receiving buprenorphine (BUP) and 15 receiving methadone (METH) treatment. HDP were randomly assigned to BUP and METH groups. Fifteen healthy subjects (CONT) were included in the study as controls. During ...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2006.02.013
更新日期：2007-01-15 00:00:00
abstract：:The aim of this study was to investigate the serum levels or activities of oxidative stress markers in patients with schizophrenia in acute phase and evaluate the changes in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH) and thiobarbituric acid-reactive substances (TBARS) a...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.01.023
更新日期：2013-10-30 00:00:00
abstract：:A woman complained of feeling a "metal-like thing" in her oral cavity 4 years after a stroke. She was convinced of the physical nature of her complaint despite intact dental and neurological findings. Somatosensory evoked magnetic fields suggested that her decreased right SII function was compensated for by the right ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2005.10.003
更新日期：2006-01-30 00:00:00
abstract：:This study examines sexual behavior, serotonin turnover in the central nervous system, and testosterone in free-ranging non-human primates. Study subjects were 33 young adult male rhesus macaques (Macaca mulatta) living in naturalistic social groups on a 475-acre South Carolina barrier island. Blood and cerebrospinal ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(97)00084-x
更新日期：1997-09-19 00:00:00
abstract：:Plasma levels of homovanillic acid (HVA), a dopamine metabolite, were examined in 19 psychiatric inpatients during maintenance treatment on neuroleptic medications. A significant positive correlation was found between the level of HVA and the severity of tardive dyskinesia (TD) in these patients. Seven patients had th...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(83)90046-x
更新日期：1983-07-01 00:00:00
abstract：:We report findings obtained with positron emission tomography with fluorodeoxyglucose-F18 (FDG PET) as tracer in two patients with acute alcohol hallucinosis. In line with previous findings, both patients had a significant hypometabolism in the left relative to the right thalamus. When the second patient was retested ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2005.05.009
更新日期：2005-08-30 00:00:00
abstract：:Controversy exists regarding the association of age with postdexamethasone serum cortisol levels. We evaluated this relationship in 95 patients with major depressive disorder and 49 healthy controls. Age and 8 a.m. postdexamethasone cortisol levels were not correlated among the healthy controls, but were positively as...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(84)90036-2
更新日期：1984-11-01 00:00:00
abstract：:Recent studies of schizophrenia have implicated deficits in processes related to working memory, but the cognitive features of these deficits have been incompletely characterized. We used a modified Brown-Peterson paradigm to compare working memory in patients with schizophrenia and in normal control subjects. Distrac...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(95)02589-3
更新日期：1995-03-27 00:00:00
abstract：:This study examined care pathways, program engagement, and key outcomes associated with a sub-acute inpatient stay in a 20-bed stand-alone Intermediate Stay Mental Health Unit (ISMHU; NSW, Australia). A 6-week evidenced-based tailored intervention program was offered, utilizing a recovery-oriented model of care. Servi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.112889
更新日期：2020-02-20 00:00:00
abstract：:Body Dysmorphic Disorder (BDD) is characterized by a distressing and impairing preoccupation with a nonexistent or slight defect in appearance. Patients with the disorder present to both psychiatric and non-psychiatric physicians. A few studies have assessed BDD prevalence in the general population and have shown that...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.07.019
更新日期：2013-12-15 00:00:00
abstract：:Platelet imipramine binding was measured in 25 unmedicated depressed patients and 25 age- and sex-matched healthy controls. In the patients, the measurement was repeated after 3 weeks and 2 months of imipramine treatment leading to clinical recovery. No significant differences in imipramine binding were found between ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(90)90040-c
更新日期：1990-09-01 00:00:00
abstract：:Overconfidence in false memories is often found in patients with schizophrenia and healthy participants with high levels of schizotypy, indicating an impairment of meta-cognition within the memory domain. In general, cognitive control is suggested to be modulated by natural fluctuations in oestrogen. However, whether ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.08.016
更新日期：2015-10-30 00:00:00
abstract：:Cognitive impairments in schizophrenia have been recognized as a prominent feature of the illness. Research is now focusing on determining a relationship between neurocognitive impairments, and social and functional outcome. Despite a number of comprehensive reviews on neurocognitive measures and reports on spatial wo...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.psychres.2006.03.018
更新日期：2007-03-30 00:00:00
abstract：:Psychiatric neuroimaging techniques are likely to improve understanding of the brain in health and disease, but studies tend to be small, based in one imaging centre and of unclear generalisability. Multicentre studies have great appeal but face problems if functional magnetic resonance imaging (fMRI) data from differ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2010.08.010
更新日期：2010-11-30 00:00:00
abstract：:The assessment of mental health consumers' functional independence is a core duty of occupational therapists. Despite the clear impact of cognition on functional outcomes, it is not always routinely assessed. We sought to explore the relationship between cognition and functional independence as well as to describe whi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.02.032
更新日期：2013-06-30 00:00:00
abstract：:We report the results of a high-density attempted suicide association study of the X chromosome, which genotyped 23,141 SNPs on 983 attempters and 1143 non-attempters and generated modest evidence for association for SH3KBP1 (P=1.07×10(-4)) and GRIA3 (P=4.01×10(-4)). These findings highlight the need for larger sample...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.06.001
更新日期：2012-12-30 00:00:00
abstract：:There is evidence that training addicted participants to implicitly avoid disorder-related stimuli by using a training version of the Approach-Avoidance Task (AAT) results in reduced substance consumption (i.e., Approach Bias Modification [AppBM]). The aim of the present web-based study was to investigate the feasibil...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2018.12.075
更新日期：2019-02-01 00:00:00
abstract：:The relationship between sleep architecture and attentional performance was evaluated in neuroleptic-naive patients with schizophrenia and healthy controls. Participants were recorded in a sleep laboratory for two consecutive nights after which selective and sustained attention performance was tested. In both groups o...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2005.11.005
更新日期：2007-01-15 00:00:00
abstract：:Eating disorders (EDs) are characterized by symptoms that reflect disturbed eating habits. Available data on EDs largely reflects a traditional latent variable model, whereby symptoms reflect an underlying entity. The network model is an alternative approach where ED symptoms do not reflect an inferred, unobservable c...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.02.027
更新日期：2018-04-01 00:00:00
abstract：:Childhood trauma exposure has been associated with a clinically relevant mixed phenotype of psychopathology composed of depressive, anxiety, and psychosis symptoms, across healthy and clinical samples. Altered stress-reactivity after exposure to childhood trauma may be a plausible underlying mechanism explaining this ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.12.012
更新日期：2018-02-01 00:00:00
abstract：:While cannabis is associated with positive syndrome schizophrenia (SZ), it is unclear whether cannabinoids are also related to negative symptoms such as affective blunting. We examined whether cannabis use is associated with schizotypy and utilized event-related potentials (ERPs) to assess affect processing. Cannabis ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2007.02.010
更新日期：2008-01-15 00:00:00
abstract：:Maternal psychopathology and the child's autonomic nervous system functioning are risk factors for aggressive behaviour later in life. While research has shown that maternal psychopathology already affects young children, less is known about the association between autonomic functioning and aggressive behaviour in you...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2009.09.014
更新日期：2011-01-30 00:00:00
abstract：:N400, an event-related brain potential (ERP) waveform elicited by meaningful stimuli, is normally reduced by stimulus repetition (N400 repetition priming), and relatedness between the eliciting stimulus and preceding ones (relatedness priming). Schizophrenia patients' N400 relatedness priming deficits suggest impairme...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.02.026
更新日期：2012-04-30 00:00:00
abstract：:Similar to members of the public, people with mental illness may exhibit general negative automatic prejudice against their own group. However, it is unclear whether more specific negative stereotypes are automatically activated among diagnosed individuals and how such automatic stereotyping may be related to self-rep...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.08.024
更新日期：2011-03-30 00:00:00
abstract：:We assess the health and wellbeing of normal adults living and working after one month of confinement to contain the COVID-19 outbreak in China. On Feb 20-21, 2020, we surveyed 369 adults in 64 cities in China that varied in their rates of confirmed coronavirus cases on their health conditions, distress and life satis...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.112958
更新日期：2020-06-01 00:00:00
abstract：:Several recent studies in animals and man indicate that corticosteroids may alter catecholaminergic activity in both the peripheral and central nervous systems. We administered 1 mg of the synthetic glucocorticoid, dexamethasone, to 12 drug-free healthy volunteers and measured plasma homovanillic acid (HVA) and 3-meth...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(85)90003-4
更新日期：1985-10-01 00:00:00
abstract：:Recent clinical studies report antipsychotics as a better option to augment the action of antidepressants in treatment resistant cases. However, the proper mechanisms underlying the antidepressant effect of antipsychotics is still not clear. Indolamine 2, 3 dioxygenase (IDO) pathway is considered to be an important pa...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.08.083
更新日期：2017-12-01 00:00:00
