Abstract：
:Platelet imipramine binding was measured in 25 unmedicated depressed patients and 25 age- and sex-matched healthy controls. In the patients, the measurement was repeated after 3 weeks and 2 months of imipramine treatment leading to clinical recovery. No significant differences in imipramine binding were found between controls and unmedicated patients. In the latter, imipramine administration produced a progressive change in the binding characteristics, increasing the apparent Kd and decreasing the number of binding sites (Bmax). The results suggest that platelet imipramine binding is not altered in depression and that changes in this parameter are the consequence of the presence of imipramine in the blood stream. However, such changes accompany changes in other biological parameters, such as platelet monoamine oxidase and serotonin uptake, seen in the same patients throughout imipramine treatment, suggesting that the drug acts on a wide range of normal or altered serotonin-related cellular mechanisms while it accelerates the clinical recovery from depression.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Quintana Jdoi
10.1016/0165-1781(90)90040-csubject
Has Abstractpub_date
1990-09-01 00:00:00pages
229-42issue
3eissn
0165-1781issn
1872-7123pii
0165-1781(90)90040-Cjournal_volume
33pub_type
杂志文章abstract：:We report the results of a high-density attempted suicide association study of the X chromosome, which genotyped 23,141 SNPs on 983 attempters and 1143 non-attempters and generated modest evidence for association for SH3KBP1 (P=1.07×10(-4)) and GRIA3 (P=4.01×10(-4)). These findings highlight the need for larger sample...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.06.001
更新日期：2012-12-30 00:00:00
abstract：:Alcohol misuse is associated with negative mental and physical health outcomes, which presents a public health concern in veterans. However, less is known regarding outcomes among veterans with low to moderate alcohol consumption. This study included veterans with military service in Iraq and/or Afghanistan (N = 1083)...
journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
abstract：:Mental illness is associated with unfair treatment in a number of areas of life. There is currently no psychometrically validated measure that has been developed to specifically focus on such experienced discrimination. This study aimed to finalise the Discrimination and Stigma Scale (DISC) and establish its psychomet...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.03.007
更新日期：2013-06-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(90)90131-n
更新日期：1990-04-01 00:00:00
abstract：:Accumulating evidences suggest that Toll-like receptors (TLRs) were involved in the pathophysiology of major depressive disorder. TLR4 was thought to be associated with major depressive disorder in animal model, but the others were still unknown. In order to examine TLR1-9 mRNA expression levels in peripheral blood an...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.07.074
更新日期：2014-12-15 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.03.001
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2002-08-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2003-06-15 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2003.12.021
更新日期：2004-04-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.07.057
更新日期：2014-12-15 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(92)90145-s
更新日期：1992-07-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.01.068
更新日期：2017-04-01 00:00:00
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doi：10.1016/j.pscychresns.2009.01.003
更新日期：2009-06-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(01)00322-5
更新日期：2001-11-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.11.027
更新日期：2018-01-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.09.008
更新日期：2015-12-15 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章,meta分析
doi：10.1016/j.psychres.2018.12.133
更新日期：2019-02-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2012.08.002
更新日期：2013-03-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(88)90015-7
更新日期：1988-03-01 00:00:00
abstract：:Dopamine agonists impair and antagonists normalize prepulse inhibition (PPI) of startle and gating of the P50 event-related potential (ERP), but the within-subject effect of treatment on impaired gating in schizophrenia has not been studied. We report the first results of a longitudinal study using PPI of ERPs as a me...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(98)00053-5
更新日期：1999-02-22 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.09.062
更新日期：2019-01-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(92)90005-n
更新日期：1992-03-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2009.04.004
更新日期：2009-10-30 00:00:00
abstract：:Individuals with a diagnosis of adult separation anxiety (ASAD) have extreme anxiety about separations, actual or imagined, from major attachment figures. ASAD might represent a psychological/behavioral model for research probably involving a dysregulation of those neurobiological mechanisms of attachment, in particul...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.04.009
更新日期：2009-07-30 00:00:00
abstract：:The distribution of platelet monoamine oxidase (MAO) activity is examined in a large cohort of 18-year-olds from a college setting. A mixture of three distributions is needed to describe the data, even when a power transformation is used to remove skewness in the distribution. This is compatible with MAO activity bein...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(82)90069-5
更新日期：1982-12-01 00:00:00
abstract：BACKGROUND:This study aims to establish if adult patients with major depressive disorder (MDD) and childhood Attention Deficit/Hyperactivity disorder (ADHD) symptoms would be more frequently within the bipolar spectrum than depressed patients without childhood ADHD. METHODS:This study was carried out in outpatients re...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.12.055
更新日期：2017-03-01 00:00:00
abstract：:This study was aimed to explore clinical differences between women and men with schizophrenia (SZ) in Latin-America. It was conducted in public mental health centers in Bolivia, Peru and Chile. Two hundred forty-seven SZ patients participated in the study, 83 (33.6%) were women and 115 (46.6%) were Aymara. Compared to...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.05.032
更新日期：2018-08-01 00:00:00
abstract：:Compared rehospitalization rates in patients with schizophrenia or bipolar I disorder to patients with major depressive disorder remains unclear. This study aimed to compare the time to rehospitalization of the three groups. Other clinical variables were also examined. Rehospitalization status was monitored for all ad...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2009.12.003
更新日期：2010-12-30 00:00:00
abstract：:The activity of phosphatidylinositol-specific phospholipase C was significantly reduced in platelets obtained from 20 euthymic manic-depressive patients on therapeutic lithium doses (mean blood level 0.85 mEq/l) compared to an age- and sex-matched group of 36 control subjects. The activities of prostaglandin E1-, alum...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(88)90138-2
更新日期：1988-04-01 00:00:00
abstract：:Adolescent offspring of schizophrenia patients (SCZ-Off) are vulnerable to psychiatric disorders. Assessing relationships between clinical and biological measures (such as functional magnetic resonance imaging, fMRI) may elucidate pathways of vulnerability in this group. Here we assessed the relationship between clini...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2010.12.005
更新日期：2011-05-31 00:00:00
