Abstract:
:Objective measures of experimentally induced aggressiveness were evaluated in heroin-dependent patients (HDP), 15 receiving buprenorphine (BUP) and 15 receiving methadone (METH) treatment. HDP were randomly assigned to BUP and METH groups. Fifteen healthy subjects (CONT) were included in the study as controls. During a laboratory task, the Point Subtraction Aggression Paradigm, subjects earned monetary reinforcement and could respond by ostensibly subtracting money from a fictitious subject (the aggressive response). Money-earning (points maintained) responses did not differ in BUP patients and in controls. In contrast, point-maintained responses were significantly lower in the group of HDP treated with METH than in both the BUP and CONT groups. Aggressive responses were significantly higher in the HDP group than in the CONT group. No significant differences in aggressive responses were found between the BUP and METH groups. Baseline concentrations of plasma adrenocorticotropic hormone (ACTH) and cortisol (CORT) were higher in HDP than in CONT. During the experimental task, ACTH and CORT increased significantly less in METH patients than in BUP patients and CONT. Norepinephrine (NE) and epinephrine (EPI) levels increased significantly more in HDP than in CONT, without any difference between the METH and BUP patients. PSAP aggressive responses positively correlated with NE and EPI changes, as well as with Buss-Durkee Hostility Inventory (BDHI) scores in both METH and BUP patients and also in CONT subjects. No correlation was found between the extent of heroin exposure, drug doses and aggressiveness levels. BUP, similarly to METH, does not seem to affect outward-directed aggressiveness, as aggressive responses related more to monoamine levels and personality traits than to the action of opioid agonists. Money-earning responses seemed to be unimpaired in BUP patients.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Gerra G,Zaimovic A,Raggi MA,Moi G,Branchi B,Moroni M,Brambilla Fdoi
10.1016/j.psychres.2006.02.013subject
Has Abstractpub_date
2007-01-15 00:00:00pages
201-13issue
1-3eissn
0165-1781issn
1872-7123pii
S0165-1781(06)00245-9journal_volume
149pub_type
杂志文章,随机对照试验abstract::The study focuses on the adaptation into Spanish and on the validation of the Social Phobia Spectrum Self-Report (SHY-SR) and the Obsessive-Compulsive Spectrum Self-Report (OBS-SR). The questionnaires were designed to measure a broad range of subtle and atypical features related to social anxiety and obsessive-compuls...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2005.07.025
更新日期:2006-06-15 00:00:00
abstract::This case highlights recurrent low-grade fevers caused by extended-release Quetiapine (Quetiapine XR), a previously unreported side effect, in a patient with Schizophreniform Disorder. While there have been case reports of Quetiapine causing neuroleptic malignant syndrome, there is paucity of data specifically describ...
journal_title:Psychiatry research
pub_type: 信件
doi:10.1016/j.psychres.2020.113583
更新日期:2021-01-01 00:00:00
abstract::Two groups of 30 patients with obsessive-compulsive disorder and 30 age- and sex-matched healthy control subjects were given a growth hormone-releasing hormone (GHRH) stimulation test to determine: (1) whether the downstream function of the somatotropic axis (growth hormone = GH, somatomedin-C = SMD-C) was impaired; (...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(98)00124-3
更新日期:1998-12-14 00:00:00
abstract::The results of the dexamethasone suppression test (DST) were compared to levels of 24-hour 3-methoxy-4-hydroxyphenylglycol (MHPG) in 60 patients with unipolar depression. DST nonsuppressors had significantly higher levels of MHPG than did DST suppressors. The possible implications of this finding are discussed. ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(88)90065-0
更新日期:1988-05-01 00:00:00
abstract::Methamphetamine (METH) users showed structural and chemical abnormalities on magnetic resonance (MRI) studies, particularly in the frontal and basal ganglia brain regions. Diffusion tensor imaging (DTI) may provide further insights regarding the microstructural changes in METH users. We investigated diffusion tensor m...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2009.03.011
更新日期:2009-10-30 00:00:00
abstract::Low electro-oculographic (EOG) ratios have been reported in patients with seasonal affective disorder (SAD) during the winter. This study evaluated the effects of the changing seasons on EOG ratios in SAD patients. Sixteen outpatients with SAD and 16 age-, sex-, and medication-matched normal volunteers had EOG testing...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(95)02788-2
更新日期:1995-11-29 00:00:00
abstract::Olfactory identification ability implicates the integrity of the orbitofrontal cortex (OFC). The fronto-striatal circuits including the OFC have been involved in the neuropathology of Obsessive Compulsive Disorder (OCD). However, only a few studies have examined olfactory function in patients with OCD. The Brief Smell...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2013.05.032
更新日期:2013-11-30 00:00:00
abstract::This study tested the hypothesis that adverse events are associated with increased risk of onset of anxiety disorders. Data from Waves 1 (N = 43,093; 2001-2002) and 2 (N = 34,653; 2004-2005) of the National Epidemiological Survey on Alcohol and Related Conditions (NESARC) were used to assess whether adverse events at ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2017.11.027
更新日期:2018-01-01 00:00:00
abstract::Suicide is a substantial public health problem, and it remains a serious cause of death in the world. Therefore, this study was designed to examine the relationships between brooding, reflection, emotional intelligence (assessed by performance-based test), and suicidal ideation; the mediation role of emotional intelli...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2015.05.046
更新日期:2015-08-30 00:00:00
abstract::Obsessive-compulsive disorder (OCD) is characterized by unwanted, intrusive and disturbing thoughts or images that cause anxiety and repetitive behaviours or mental acts to relieve these thoughts or images. Considering controversial aetiology of OCD and growing evidence for the role of inflammation in OCD, the aim of ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2020.113065
更新日期:2020-08-01 00:00:00
abstract::New methods for determination of specific concentration and molecular activity of monoamine oxidase (MAO) in platelets are described and evaluated in parallel with specific activity measures, performed in whole platelets and platelet extracts. Platelet MAO specific concentration is determined in platelet extracts by a...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(86)90068-5
更新日期:1986-02-01 00:00:00
abstract::Prior studies have confirmed a bias against disconfirmatory evidence (BADE) in schizophrenia which has been associated with delusions. However, its role in the pathogenesis of psychosis is yet unclear. The objective was to investigate BADE for the first time in subjects with an at-risk-mental-state for psychosis (ARMS...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.02.028
更新日期:2016-04-30 00:00:00
abstract::The Morningness-Eveningness Questionnaire (MEQ) is among the most commonly used scales to measure chronotype. We aimed to evaluate psychometric properties and clinical correlates of MEQ in bipolar disorder. Patients with a clinical diagnosis of bipolar disorder (n = 53) answered questionnaires for chronotype (MEQ), mo...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.02.004
更新日期:2018-04-01 00:00:00
abstract::Ninety-one patients treated with amitriptyline and 60 normal control subjects underwent a standardized heart rate analysis in supine posture. Tests included the determination of time- and frequency-derived measurements of heart rate variability. The patients differed significantly from the control subjects in all para...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(95)02511-t
更新日期:1995-04-28 00:00:00
abstract::Semantically incoherent speech is a pernicious clinical feature of serious mental illness (SMI). The precise mechanisms underlying this deficit remain unclear. Prior studies have found that arousal of negative emotion exaggerates the severity of these communication disturbances; this has been coined "affective reactiv...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.12.025
更新日期:2017-02-01 00:00:00
abstract::Ten long-term abstinent alcoholics (mean abstinence = 7.7 years) were compared with 13 recently detoxified substance-dependent inpatients (mean abstinence = 25 days) and 8 nonalcoholic control subjects on global end regional measures of cortical cerebral blood flow (CBF), and on neuropsychological measures. CBF was as...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0925-4927(96)02769-2
更新日期:1996-07-31 00:00:00
abstract::The association between orbital frontal cortex (OFC) volume and aggression was investigated in an at-risk psychiatric population. Forty-one psychiatric patients were referred for magnetic resonance imaging and a standardized psychometric assessment of aggression (Lifetime History of Aggression-Revised). Nineteen match...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2008.03.007
更新日期:2009-03-31 00:00:00
abstract::Dementia with Lewy bodies (DLB) is a common form of dementia, with fewer memory deficits, and more visuo-perceptual problems than Alzheimer's disease (AD). We hypothesized that there would be disease specific alterations revealed by diffusion tensor imaging with AD showing temporal lobe and DLB more parietal changes. ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2007.01.001
更新日期:2007-07-15 00:00:00
abstract::Abnormalities of electroencephalographic (EEG) coherence in schizophrenia are thought to reflect functional disconnections between different brain regions associated with the onset of this disease. To clarify whether these abnormalities change in a symptom-dependent manner in individual patients, we analyzed the coher...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2005.05.020
更新日期:2007-01-15 00:00:00
abstract::Twenty-two patients who met the Utah criteria for attention deficit disorder, residual type (hyperactivity, minimal brain dysfunction in adults) received an open trial of pargyline (Eutonyl). Of these 22 patients, 13 (59%) showed a moderate to marked therapeutic response. Clinically useful features of pargyline in the...
journal_title:Psychiatry research
pub_type: 临床试验,杂志文章
doi:10.1016/0165-1781(83)90006-9
更新日期:1983-08-01 00:00:00
abstract::Studies which showed anticipation in families with schizophrenia suggested that a trinucleotide repeat expansion mechanism may be involved in the pathogenesis of familial schizophrenia. Furthermore, some studies involving the repeat expansion detection (RED) method showed the median length of CAG repeats to be longer ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(00)00156-6
更新日期:2000-07-17 00:00:00
abstract::An epidemiological survey on anorexia nervosa was performed in Japanese hospitals in 1985 and 1992 using a questionnaire. The reported number of patients with anorexia nervosa was 2391 from 732 institutions. From these data, the total number of anorexia nervosa patients treated in 1985 in Japanese hospitals was estima...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(96)02988-5
更新日期:1996-04-16 00:00:00
abstract::The construction and initial psychometric evaluation of an interview assessment of clinically significant impulsivity (Lifetime History of Impulsive Behaviors; LHIB) is presented. Personality-disordered and control subjects participated by completing self-report measures of depression, anxiety and social desirability,...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2003.12.021
更新日期:2004-04-30 00:00:00
abstract::Persistent infection with Herpes Simplex viruses (HSV) and other brain infections is consistently associated with cognitive impairment. These infections can also affect sleep. Thus, sleep abnormalities could explain the cognitive dysfunction. We investigated the association between sleep variables and persistent HSV-1...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2019.112502
更新日期:2019-10-01 00:00:00
abstract::In a previous study, we reported a nonrandom segregation between schizophrenia and the pseudoautosomal locus DXYS14 in a sample of 33 sibships. That study has been extended by the addition of 16 new sibships from 16 different families. Data from six other loci of the pseudoautosomal region and of the immediately adjac...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(94)90083-3
更新日期:1994-05-01 00:00:00
abstract::Intracranial volume (ICV) normalization of regional brain volumes (v) is common practice in volumetric studies of the aging brain. Multiple normalization methods exist and this study aimed to investigate when each method is appropriate to use in gender dimorphism studies and how differences in v are affected by the ch...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2014.11.011
更新日期:2015-03-30 00:00:00
abstract::Recent investigations suggest that serotonergic mechanisms modulate dimensions of personality, in particular decreases in Anger-Hostility and increases in Affiliation. None of these studies, however, demonstrated a specific serotonergic effect on personality, as other neurotransmitter systems have not been assessed fo...
journal_title:Psychiatry research
pub_type: 临床试验,杂志文章
doi:10.1016/s0165-1781(99)00041-4
更新日期:1999-06-30 00:00:00
abstract::Mild traumatic brain injury (mTBI) is a common occurrence, and may impact distal outcomes in a subgroup of individuals. Improved characterization of health outcomes and identification of factors associated with poor outcomes is needed to better understand the impact of mTBI, particularly in those with co-occurring pos...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.12.021
更新日期:2019-02-01 00:00:00
abstract::The dopamine hypothesis of schizophrenia received strong support when a two- to three-fold elevation of D2 receptor densities was demonstrated by positron emission tomography (PET) and [11C]N-methylspiperone ([11C]NMSP). In the present study, the reproducibility of this finding was examined by application of a similar...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0925-4927(95)02732-d
更新日期:1995-08-08 00:00:00
abstract::Abnormalities in the neurohypophyseal system have been reported in depression. This study aimed to investigate serum oxytocin levels in patients with depression and the effects of gender and antidepressant treatment on these levels. Serum oxytocin levels were measured before and after treatment with antidepressant dru...
journal_title:Psychiatry research
pub_type: 临床试验,杂志文章
doi:10.1016/j.psychres.2008.06.034
更新日期:2009-10-30 00:00:00