Abstract：
:Impaired visual integration is well documented in schizophrenia and related to functional outcomes. However, it is unclear if this deficit is specific to schizophrenia, or characteristic of psychosis more broadly. To address this question, this study used a Bayesian model comparison approach to examine the evidence of three grouping models of visual integration performance in 116 individuals with schizophrenia (SZ), schizoaffective disorder (SA), bipolar disorder (BD) with or without a history of prominent psychosis (BDP+ and BDP-, respectively), or no psychiatric diagnosis (healthy controls; HC). We compared: (1) Psychosis Model (psychosis, non-psychosis), where the psychosis group included SZ, SA, and BDP+, and the non-psychosis group included BDP- and HC; (2) Schizophrenia Model (SZ, non-SZ); and (3) DSM Model (SZ, SA, BD, HC). The relationship between visual integration and general cognition was also explored. The Psychosis Model showed the strongest evidence, and visual integration was associated with general cognition in participants with psychosis. The results were consistent with the Research Domain Criteria (RDoC) framework, indicating that visual integration impairment is characteristic of psychosis and not specific to SZ or DSM categories, and may share similar disease pathways with observed neurocognitive deficits in psychotic disorders.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Grove TB,Yao B,Mueller SA,McLaughlin M,Ellingrod VL,McInnis MG,Taylor SF,Deldin PJ,Tso IFdoi
10.1016/j.psychres.2018.04.061subject
Has Abstractpub_date
2018-07-01 00:00:00pages
271-278eissn
0165-1781issn
1872-7123pii
S0165-1781(17)31164-2journal_volume
265pub_type
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