Timing of clinical improvement and symptom resolution in the treatment of major depressive disorder.


:The goal of the present work is to assess for the relationship between the timing of clinical improvement and the resolution of depressive symptoms in Major Depressive Disorder (MDD). 182 MDD outpatients (40.5+/-9.7 years; 53.8% female) who responded following an 8-week, 20 mg, open trial of fluoxetine were included in the analysis. The symptoms questionnaire (SQ) and Beck hopelessness scale (BHS) were also administered to 83 and 153 of these patients, respectively. Onset of clinical improvement was defined as a 30% decrease in 17-item Hamilton depression scale (HDRS-17) scores. Controlling for baseline symptom severity, we then assessed for the relationship between the timing of clinical improvement and depressive symptom at endpoint. Earlier clinical improvement in responders predicted lower HDRS-17, BHS, SQ-depression, SQ-anxiety, but not SQ-somatic symptom or SQ-anger/hostility scores at week 8. This was true regardless of whether improvement was defined as a continuous measure (30% decrease in symptom severity), as a dichotomous measure (clinical response occurring in the first two weeks of treatment). In conclusion, earlier clinical improvement with fluoxetine treatment is predictive of greater symptom resolution at endpoint. Further studies exploring the impact of various treatment modalities and placebo on the timing of clinical improvement and symptom resolution in MDD are warranted.


Psychiatry Res


Psychiatry research


Papakostas GI,Petersen T,Sklarsky KG,Nierenberg AA,Alpert JE,Fava M




Has Abstract


2007-01-15 00:00:00














  • A systematic review of treatments for Impulse Control Disorders and related behaviours in Parkinson's disease.

    abstract::Impulse Control Disorders (ICDs) are a set of behaviours characterised by impulsivity despite known harm. Related to ICDs is the dopamine dysregulation syndrome (DDS), which is characterised by an addiction-like consumption of dopaminergic medication and punding. These behaviours all have an increased prevalence in Pa...

    journal_title:Psychiatry research

    pub_type: 杂志文章,评审


    authors: Tanwani P,Fernie BA,Nikčević AV,Spada MM

    更新日期:2015-02-28 00:00:00

  • Altered pineal serotonin binding in some suicides.

    abstract::Serotonergic abnormalities have been regularly reported in the brains of suicide victims. Because of evidence that pineal function is altered in depressed subjects and that serotonin-releasing axons may innervate the pineal, we assayed tritiated serotonin binding in a series of control and suicide pineals. High affini...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Sparks DL,Little KY

    更新日期:1990-04-01 00:00:00

  • The psychometric validation of the Sheehan Disability Scale (SDS) in patients with bipolar disorder.

    abstract::Bipolar disorder (BD) adversely affects daily activities/functioning. The Sheehan Disability Scale (SDS) assesses disability in work/school activities, family relationships, and social functioning, and it evaluates the functional impact of psychiatric disorders. BD outpatients from 21 U.S. sites completed a battery of...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Arbuckle R,Frye MA,Brecher M,Paulsson B,Rajagopalan K,Palmer S,Degl' Innocenti A

    更新日期:2009-01-30 00:00:00

  • An examination of the measurement adequacy of the CES-D among African American women family caregivers.

    abstract::The Center for Epidemiologic Studies Depression Scale (CES-D) has been used extensively in community-based surveys to describe and explain the prevalence of depression in the general population. Yet, questions have been raised regarding its adequacy for use among ethnic minority because of its factor variance. Employi...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Rozario PA,Menon N

    更新日期:2010-08-30 00:00:00

  • Evidence of some strategic preservation of episodic learning in patients with schizophrenia.

    abstract::The aim of this study was to gain a better understanding of schizophrenia patients' strategic use of learning time allocation during encoding, and determine whether they are able to use their monitoring and previous performances to adapt their learning behavior efficiently. Schizophrenia is considered to be a patholog...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Thuaire F,Izaute M,Bacon E

    更新日期:2012-01-30 00:00:00

  • Urinary MHPG and clinical symptoms in patients with unipolar depression.

    abstract::The relationship between levels of urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) and symptom scores on the Hamilton Rating Scale for Depression was examined in 31 patients with unipolar depression. Patients with either low MHPG or high MHPG showed significant sleep disturbance in the form of early morning awakening. ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Samson JA,Mirin SM,Griffin M,Borrelli D,Schildkraut JJ

    更新日期:1994-02-01 00:00:00

  • Gender moderates the association between dorsal medial prefrontal cortex volume and depressive symptoms in a subclinical sample.

    abstract::Major depressive disorder is associated with lower medial prefrontal cortex volumes. The role that gender might play in moderating this relationship and what particular medial prefrontal cortex subregion(s) might be implicated is unclear. Magnetic resonance imaging was used to assess dorsal, ventral, and anterior cing...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Carlson JM,Depetro E,Maxwell J,Harmon-Jones E,Hajcak G

    更新日期:2015-08-30 00:00:00

  • Catechol-O-methyltransferase Val158Met polymorphism affects therapeutic response to mood stabilizer in symptomatic manic patients.

    abstract::Catechol-O-methyltransferase (COMT) is a candidate gene for the pathogenesis of some psychiatric disorders. The aim of this study is to examine the role of the COMT gene Val158Met polymorphism on the clinical aspects of bipolar disorder including symptomatology and therapeutic response. This study comprised 144 unrela...

    journal_title:Psychiatry research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lee HY,Kim YK

    更新日期:2010-01-30 00:00:00

  • Baseline level of platelet-leukocyte aggregates, platelet CD63 expression, and soluble P-selectin concentration in patients with posttraumatic stress disorder: a pilot study.

    abstract::Platelets may have an important role in the development of cardiovascular disease (CVD) as a result of chronic stress. We conducted a pilot study to evaluate the effect of posttraumatic stress disorder (PTSD) on baseline platelet activation. Platelet-leukocyte aggregates (PLA) and CD63 expression were measured by flow...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Vidović A,Vilibić M,Markotić A,Sabioncello A,Gotovac K,Folnegović-Smalc V,Dekaris D

    更新日期:2007-03-30 00:00:00

  • Brain perfusion in Alzheimer's disease with and without apathy: a SPECT study with statistical parametric mapping analysis.

    abstract::Alzheimer's disease (AD) is clinically characterized by cognitive symptoms that, in combination with behavioral disturbances, significantly interfere with activities of daily living. These behavioral disorders contribute to the clinical heterogeneity of the disease and probably express different pathophysiological pro...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Benoit M,Koulibaly PM,Migneco O,Darcourt J,Pringuey DJ,Robert PH

    更新日期:2002-06-15 00:00:00

  • Failure to replicate linkage between chromosome 5q11-q13 markers and schizophrenia in 28 families.

    abstract::Sherrington et al. (1988) reported linkage between markers located on the 5q11-q13 region of chromosome 5 and schizophrenia in five Icelandic and two British families. To date, however, all attempts to replicate the initial finding have failed. Using three markers of chromosome 5, we have studied 28 additional French ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Campion D,d'Amato T,Laklou H,Sabate O,Jay M,Leboyer M,Malafosse A,Gorwood P,Babron MC,Hillaire D

    更新日期:1992-12-01 00:00:00

  • Decreased serum levels of adiponectin in adult attention deficit hyperactivity disorder.

    abstract::The main aim of this study was to investigate serum levels of adiponectin in adult patients with attention deficit hyperactivity disorder (ADHD). The second objective was to examine the effects of rare missense mutations in T-cadherin, an adiponectin receptor encoded by the ADHD candidate gene CDH13, on serum adiponec...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Mavroconstanti T,Halmøy A,Haavik J

    更新日期:2014-04-30 00:00:00

  • No evidence of linkage between the dopamine D2 receptor gene and schizophrenia.

    abstract::The antipsychotic effects of dopamine D2 receptor antagonists (neuroleptics) and the psychotomimetic effects of dopamine agonists suggest that a defect of the D2 receptor gene might be a factor in the etiology of schizophrenia. Fifteen families that contained several members suffering from schizophrenia were tested fo...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Hallmayer J,Maier W,Schwab S,Ertl MA,Minges J,Ackenheil M,Lichtermann D,Wildenauer DB

    更新日期:1994-08-01 00:00:00

  • Physiological characteristics of platelet/circulatory serotonin: study on a large human population.

    abstract::The aim of this work was the study of platelet/circulatory serotonin (5-hydroxytryptamine, 5-HT), specifically alternative ways of its measurement and main physiological characteristics. The study was performed on a large human population (N=500) of blood donors of both sexes over the course of a longer time period (1...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Jernej B,Banović M,Cicin-Sain L,Hranilović D,Balija M,Oresković D,Folnegović-Smalc V

    更新日期:2000-05-15 00:00:00

  • Frontal CSF enlargement in panic disorder: a qualitative CT-scan study.

    abstract::Brain morphology was assessed qualitatively in CT scans of 21 patients with panic disorder and 21 normal control subjects. Patients showed significant bilateral enlargement of frontal cerebrospinal fluid (CSF) spaces. These findings suggest that alterations in brain morphology are involved in the etiology of panic dis...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Wurthmann C,Bogerts B,Gregor J,Baumann B,Effenberger O,Döhring W

    更新日期:1997-12-30 00:00:00

  • Dealing with feeling: Specific emotion regulation skills predict responses to stress in psychosis.

    abstract::Elevated negative affect is an established link between minor stressors and psychotic symptoms. Less clear is why people with psychosis fail to regulate distressing emotions effectively. This study tests whether subjective, psychophysiological and symptomatic responses to stress can be predicted by specific emotion re...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Lincoln TM,Hartmann M,Köther U,Moritz S

    更新日期:2015-08-15 00:00:00

  • Disruptions to processing of self referential emotional material are associated with positive symptoms of schizotypy.

    abstract::The current experiment examined emotional processing difficulties related to self referential material in high schizotypal individuals employing the mnemic neglect paradigm. Participants read about behaviors, in reference to themselves, that were either central or peripheral, and positive or negative, before recalling...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Saunders J,Vallath S,Reed P

    更新日期:2015-10-30 00:00:00

  • Psychiatric emergency care during Coronavirus 2019 (COVID 19) pandemic lockdown: results from a Department of Mental Health and Addiction of northern Italy.

    abstract:BACKGROUND:The current COVID-19 pandemic and the consequent containment measures are leading to increasing mental health issues both in psychiatric patients and general population. OBJECTIVE:We aimed to compare the number and characteristics of emergency psychiatric consultations during the phase 1 of lockdown with re...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Capuzzi E,Di Brita C,Caldiroli A,Colmegna F,Nava R,Buoli M,Clerici M

    更新日期:2020-11-01 00:00:00

  • Psychoeducation in anxiety disorders: Results of a survey of all psychiatric institutions in Germany, Austria and Switzerland.

    abstract::The aim was to study the distribution of psychoeducation for anxiety disorders using a two-part survey addressing all psychiatric institutions in Germany, Austria and Switzerland. We found that 77% of the patients with anxiety disorders participated in psychoeducation when it was offered. However, only 8% of the insti...

    journal_title:Psychiatry research

    pub_type: 杂志文章,多中心研究


    authors: Rummel-Kluge C,Pitschel-Walz G,Kissling W

    更新日期:2009-09-30 00:00:00

  • The role of premorbid personality and social cognition in suicidal behaviour in first-episode psychosis: A one-year follow-up study.

    abstract:BACKGROUND:High suicide attempt (SA) rates have been reported in first-episode psychosis (FEP) patients, particularly during the first year after the illness onset. Despite previous studies establishing several risk factors for suicidal behaviour in FEP, premorbid personality and social cognition have not been sufficie...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Canal-Rivero M,Lopez-Moriñigo JD,Barrigón ML,Perona-Garcelán S,Jimenez-Casado C,David AS,Obiols-Llandrich JE,Ruiz-Veguilla M

    更新日期:2017-10-01 00:00:00

  • A network analysis of eating disorder symptoms and characteristics in an inpatient sample.

    abstract::Eating disorders (EDs) are characterized by symptoms that reflect disturbed eating habits. Available data on EDs largely reflects a traditional latent variable model, whereby symptoms reflect an underlying entity. The network model is an alternative approach where ED symptoms do not reflect an inferred, unobservable c...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Olatunji BO,Levinson C,Calebs B

    更新日期:2018-04-01 00:00:00

  • Automatic stereotyping against people with schizophrenia, schizoaffective and affective disorders.

    abstract::Similar to members of the public, people with mental illness may exhibit general negative automatic prejudice against their own group. However, it is unclear whether more specific negative stereotypes are automatically activated among diagnosed individuals and how such automatic stereotyping may be related to self-rep...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Rüsch N,Corrigan PW,Todd AR,Bodenhausen GV

    更新日期:2011-03-30 00:00:00

  • Changes in physical activity, physical fitness, self-perception and quality of life following a 6-month physical activity counseling and cognitive behavioral therapy program in outpatients with binge eating disorder.

    abstract::The aim of the current study was to explore the associations between changes in the number of binges, physical activity participation, physical fitness, physical self-perception and quality of life following a 6-month physical activity counseling and cognitive behavioral program in patients with binge eating disorder ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Vancampfort D,Probst M,Adriaens A,Pieters G,De Hert M,Stubbs B,Soundy A,Vanderlinden J

    更新日期:2014-10-30 00:00:00

  • Probing the magnocellular and parvocellular visual pathways in facial emotion perception in schizophrenia.

    abstract::Schizophrenia patients have well-established deficits in facial emotion perception, which contribute to their poor social functioning. A number of studies have related these deficits to a differential dysfunction in the magnocellular (M) versus parvocellular (P) visual pathway. We assessed 35 schizophrenia patients an...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Jahshan C,Wolf M,Karbi Y,Shamir E,Rassovsky Y

    更新日期:2017-07-01 00:00:00

  • Serotonin 1A receptor gene, schizophrenia and bipolar disorder: an association study and meta-analysis.

    abstract::Several investigations have reported associations between serotonin 1A (5-HT1A) receptor and major psychiatric disorders, such as schizophrenia and bipolar disorder (BP), making the 5-HT1A receptor gene (HTR1A) a good candidate gene for the pathophysiology of schizophrenia and BP. To evaluate the association between H...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Kishi T,Okochi T,Tsunoka T,Okumura T,Kitajima T,Kawashima K,Yamanouchi Y,Kinoshita Y,Naitoh H,Inada T,Kunugi H,Kato T,Yoshikawa T,Ujike H,Ozaki N,Iwata N

    更新日期:2011-01-30 00:00:00

  • Attentional biases in patients suffering from unipolar depression: results of a dot probe task investigation.

    abstract::Cognitive models of depression emphasize the relevance of cognitive biases for development, onset and maintenance of major depressive disorder (MDD). Attentional biases consisting of increased attention to negative, mood congruent stimuli and reduced attention to positive, mood-incongruent stimuli are postulated but h...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Trapp W,Kalzendorf C,Baum C,Hajak G,Lautenbacher S

    更新日期:2018-03-01 00:00:00

  • Predicting dementia development in Parkinson's disease using Bayesian network classifiers.

    abstract::Parkinson's disease (PD) has broadly been associated with mild cognitive impairment (PDMCI) and dementia (PDD). Researchers have studied surrogate, neuroanatomic biomarkers provided by magnetic resonance imaging (MRI) that may help in the early diagnosis of this condition. In this article, four classification models (...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Morales DA,Vives-Gilabert Y,Gómez-Ansón B,Bengoetxea E,Larrañaga P,Bielza C,Pagonabarraga J,Kulisevsky J,Corcuera-Solano I,Delfino M

    更新日期:2013-08-30 00:00:00

  • Platelet serotonergic functions and light therapy in seasonal affective disorder.

    abstract::We investigated platelet 14C-serotonin uptake and platelet [3H]LSD and [3H]paroxetine binding in 11 patients with seasonal affective disorder (SAD). Patients were reinvestigated after light therapy, applied at 07.00-09.00 h for 10 consecutive days. The degree of depression was rated before and after light therapy usin...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Stain-Malmgren R,Kjellman BF,Aberg-Wistedt A

    更新日期:1998-05-08 00:00:00

  • Association between VNTR polymorphism in promoter region of prodynorphin (PDYN) gene and heroin dependence.

    abstract::Within the core promoter region of prodynorphin (PDYN), a 68-bp sequence was found to occur as a polymorphism element, either singular or as tandemly repeated two, three or four times. We report the sequence of a novel allele (5-repeats). Our study revealed the existence of an ancestral nucleotide (A) at 29th position...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Saify K,Saadat I,Saadat M

    更新日期:2014-11-30 00:00:00

  • Lack of effect of dopamine receptor blockade on the TSH response to TRH in borderline personality disorder.

    abstract::We recently reported that some patients with borderline personality disorder (BPD) exhibit a blunted thyrotropin (thyroid-stimulating hormone; TSH) response to thyrotropin-releasing hormone (TRH). Because it is known that dopamine can inhibit the TSH response to TRH and that some patients with BPD show improvement wit...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Garbutt JC,Loosen PT,Glenn M

    更新日期:1987-08-01 00:00:00