Abstract：
:The goal of the present work is to assess for the relationship between the timing of clinical improvement and the resolution of depressive symptoms in Major Depressive Disorder (MDD). 182 MDD outpatients (40.5+/-9.7 years; 53.8% female) who responded following an 8-week, 20 mg, open trial of fluoxetine were included in the analysis. The symptoms questionnaire (SQ) and Beck hopelessness scale (BHS) were also administered to 83 and 153 of these patients, respectively. Onset of clinical improvement was defined as a 30% decrease in 17-item Hamilton depression scale (HDRS-17) scores. Controlling for baseline symptom severity, we then assessed for the relationship between the timing of clinical improvement and depressive symptom at endpoint. Earlier clinical improvement in responders predicted lower HDRS-17, BHS, SQ-depression, SQ-anxiety, but not SQ-somatic symptom or SQ-anger/hostility scores at week 8. This was true regardless of whether improvement was defined as a continuous measure (30% decrease in symptom severity), as a dichotomous measure (clinical response occurring in the first two weeks of treatment). In conclusion, earlier clinical improvement with fluoxetine treatment is predictive of greater symptom resolution at endpoint. Further studies exploring the impact of various treatment modalities and placebo on the timing of clinical improvement and symptom resolution in MDD are warranted.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Papakostas GI,Petersen T,Sklarsky KG,Nierenberg AA,Alpert JE,Fava Mdoi
10.1016/j.psychres.2006.03.014subject
Has Abstractpub_date
2007-01-15 00:00:00pages
195-200issue
1-3eissn
0165-1781issn
1872-7123pii
S0165-1781(06)00087-4journal_volume
149pub_type
杂志文章abstract：:Impulse Control Disorders (ICDs) are a set of behaviours characterised by impulsivity despite known harm. Related to ICDs is the dopamine dysregulation syndrome (DDS), which is characterised by an addiction-like consumption of dopaminergic medication and punding. These behaviours all have an increased prevalence in Pa...
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pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Psychiatry research
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/0165-1781(87)90014-x
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