Abstract：
:The question of whether Tourette's syndrome (TS) and trichotillomania (TTM) are best conceptualized as obsessive-compulsive spectrum disorders was raised by family studies demonstrating a close relationship between TS and obsessive-compulsive disorder (OCD), and by psychopharmacological research indicating that both TTM and OCD respond more robustly to clomipramine than to desipramine. A range of studies have subsequently allowed comparison of the phenomenology, psychobiology, and management of TS and TTM, with that of OCD. Here we briefly review this literature. The data indicate that there is significant psychobiological overlap between TS and OCD, supporting the idea that TS can be conceptualized as an OCD spectrum disorder. TTM and OCD have only partial overlap in their phenomenology and psychobiology, but there are a number of reasons for why it may be useful to classify TTM and other habit disorders as part of the obsessive-compulsive spectrum of disorders.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Ferrão YA,Miguel E,Stein DJdoi
10.1016/j.psychres.2008.06.008subject
Has Abstractpub_date
2009-11-30 00:00:00pages
32-42issue
1eissn
0165-1781issn
1872-7123pii
S0165-1781(08)00175-3journal_volume
170pub_type
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