Abstract：
:Changes of serotonin2 (5HT2) receptors have been described in depression, and long-term antidepressant treatment has been shown to decrease the number of 5HT2 receptors. In this study, single photon emission computed tomography (SPECT), with 2-123I-ketanserin as a ligand, was used to investigate 5HT2 receptors in vivo in the brain of depressed patients and normal volunteers. A higher uptake of the tracer was observed in the parietal cortex of the patients, and there was a right greater than left asymmetry in the infero-frontal region of the depressed subjects and not in that of the control subjects. These findings could indicate changes in 5HT2 receptors in major depression.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
D'haenen H,Bossuyt A,Mertens J,Bossuyt-Piron C,Gijsemans M,Kaufman Ldoi
10.1016/0925-4927(92)90018-ysubject
Has Abstractpub_date
1992-12-01 00:00:00pages
227-37issue
4eissn
0165-1781issn
1872-7123journal_volume
45pub_type
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