Abstract:
:Childhood maltreatment history is a prevalent risk factor for substance use disorder and has lifelong adverse consequences on psychiatric wellbeing. The role of personality variations in determining childhood maltreatment-associated outcomes is poorly understood. This study sought to test neuroticism and agreeableness as mediator and moderator, respectively, of functional outcomes associated with having a history of childhood maltreatment and presence/absence of cocaine dependence. Ninety-four participants completed the Structured Clinical Interview for DSM-IV (SCID-IV), Childhood Trauma Questionnaire (CTQ), NEO-Five Factor Inventory (NEO-FFI), and the Addiction Severity Index (ASI). The distribution-of-the-product strategy tested if neuroticism mediated the relationship between CTQ and ASI scores. Agreeableness was tested as a moderator using bootstrapped multiple regression analyses with agreeableness*CTQ interaction terms as predictors of ASI scores. Analyses covaried for cocaine dependence to determine its influence. Neuroticism mediated the relationship between severity of childhood maltreatment history and family (ASI-Family) and psychiatric (ASI-Psychiatric) dysfunction in adulthood, independent of cocaine dependence. Agreeableness negatively moderated the effect of childhood maltreatment severity on family dysfunction. Exposure to emotional neglect and abuse selectively drove the mediation and moderation effects. Personality-directed interventions that reduce neuroticism or increase agreeableness may be promising approaches to uncouple childhood maltreatment history from lifelong social and psychiatric dysfunction.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Brents LK,James GA,Cisler JM,Kilts CDdoi
10.1016/j.psychres.2018.07.010subject
Has Abstractpub_date
2018-10-01 00:00:00pages
229-237eissn
0165-1781issn
1872-7123pii
S0165-1781(18)30116-1journal_volume
268pub_type
杂志文章abstract::Proton magnetic resonance spectroscopy ((1)H MRS) has revealed biochemical alterations in various psychiatric disorders. Changes in brain metabolites may be caused not only by the disease's progression or response to treatment, but also by physiological variability. The aim of this study was to use (1)H MRS to assess ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2006.01.010
更新日期:2006-06-30 00:00:00
abstract::Absent lunula can progressively develop in a person who previously had a normal-sized lunula and can be associated with various systemic disorders. In this case-control study we hypothesised that absent lunula is associated with depression. The study comprised 332 depressive outpatients as well as 367 age- and sex-mat...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2012.08.011
更新日期:2013-01-30 00:00:00
abstract::The immense burden of health conditions in children that is associated with mental disorders worldwide is increasingly being recognized. In comparison, the burden of disability associated with children's impairments of psychological functions (IPFs) is not well documented. The goal of this population-based study was t...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2010.03.001
更新日期:2010-05-15 00:00:00
abstract::Obsessive-compulsive disorder (OCD) is characterized by unwanted, intrusive and disturbing thoughts or images that cause anxiety and repetitive behaviours or mental acts to relieve these thoughts or images. Considering controversial aetiology of OCD and growing evidence for the role of inflammation in OCD, the aim of ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2020.113065
更新日期:2020-08-01 00:00:00
abstract::Recent clinical studies report antipsychotics as a better option to augment the action of antidepressants in treatment resistant cases. However, the proper mechanisms underlying the antidepressant effect of antipsychotics is still not clear. Indolamine 2, 3 dioxygenase (IDO) pathway is considered to be an important pa...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2017.08.083
更新日期:2017-12-01 00:00:00
abstract::Deciding whether to disclose one's psychiatric disorder to a prospective employer is a complex decision for people with severe mental illness seeking to return to work, with potential advantages and disadvantages. The present study examined the rates, patterns, and correlates of disclosure in 51 participants (74.5% sc...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2019.01.017
更新日期:2019-03-01 00:00:00
abstract::Impairments on neuropsychological and eye movement tasks have been demonstrated in schizophrenic patients and also reported in their unaffected relatives. However, it is not clear to what extent these phenotypes overlap. This study examined the relationship between specific eye movement and neuropsychological measures...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2008.05.008
更新日期:2009-08-15 00:00:00
abstract::Impairments in source monitoring have been widely reported in schizophrenia, with patients typically misattributing self-generated items to external sources. Some studies have reported that patients with more severe positive symptoms (notably hallucinations) exhibit a greater impairment on these tasks, although findin...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2007.02.018
更新日期:2008-06-30 00:00:00
abstract::The current study aimed to prove the antidepressant-like effects and the probable mechanisms of Schisandrin on depression, which induced by chronic unpredictable mild stress (CUMS) in mice. Four weeks of CUMS exposure resulted in depressive-like behavior, as indicated by the significant decrease in sucrose consumption...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2017.07.081
更新日期:2017-11-01 00:00:00
abstract::The current study aimed to explore Israelis' state anxiety due to a Syrian-Israeli incident that occurred on February 10, 2018, when an Israeli F-16 fighter jet was shot down by Syrian air defense forces. In line with the "looming vulnerability" model which emphasizes the importance of the dynamic nature of psychologi...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.10.072
更新日期:2018-12-01 00:00:00
abstract::Our study aimed to examine the interplay between clinical and social predictors of future suicide attempt and the transition from suicidal ideation to suicide attempt in depressive disorders. Sixty-six Malaysian inpatients with a depressive disorder were assessed at index admission and within 1 year for suicide attemp...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2014.08.055
更新日期:2014-12-30 00:00:00
abstract::Suicidal behavior is a major health risk in psychiatric disorders, especially in schizophrenia, wherein up to 10% patients will commit suicide. However, the neurobiology of suicide is still unclear. Suicidality has been related to decreased central serotonergic (5-hydroxytryptamine, 5-HT) function and reduced choleste...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2006.08.012
更新日期:2007-02-28 00:00:00
abstract::The main goal of this study it is explore the psychopathological differences between IPD and SIPD in a sample of 125 adults with a lifetime diagnosis of cocaine disorder recruited from treatment setting and through street contacts. A secondary analysis of six cross-sectional studies was conducted between 2000 and 2010...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.05.043
更新日期:2016-08-30 00:00:00
abstract::Although married women are increasingly participating in paid labor, housework remains their primary responsibility. This uneven distribution of housework could have a negative impact on their mental health. In this study, we examined the association between satisfaction with husbands' participation in housework and s...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.01.039
更新日期:2018-03-01 00:00:00
abstract::One of the leading biosocial theories of borderline personality disorder (BPD) suggests that individuals with BPD have biologically based abnormalities in emotion regulation contributing to more intense and rapid responses to emotional stimuli, in particular, invalidation [Linehan, M.M., 1993. Cognitive-Behavioral Tre...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2007.06.007
更新日期:2008-01-15 00:00:00
abstract::Studies using a variety of investigative methods, including functional brain imaging and electroencephalography (EEG), have suggested that changes in central nervous system (CNS) dopamine function result in altered visual system processing. The discovery of abnormal retinal blue cone, but not red cone, electroretinogr...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0925-4927(00)00074-3
更新日期:2000-12-22 00:00:00
abstract::The association between orbital frontal cortex (OFC) volume and aggression was investigated in an at-risk psychiatric population. Forty-one psychiatric patients were referred for magnetic resonance imaging and a standardized psychometric assessment of aggression (Lifetime History of Aggression-Revised). Nineteen match...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2008.03.007
更新日期:2009-03-31 00:00:00
abstract::The subgenual prefrontal cortex (SGPFC) plays an important role in emotional processing. We carried out a magnetic resonance imaging (MRI) study comparing the volume of the SGPFC in child and adolescent bipolar patients and healthy controls. The sample consisted of 15 children and adolescents who met DSM-IV criteria f...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2004.11.004
更新日期:2005-01-30 00:00:00
abstract::Panic disorder (PD) and social phobia (SP) share many clinical, demographic and biological characteristics. To investigate the relationships between the two disorders, the responses to inhalation of a 35% carbon-dioxide (CO2) and 65% oxygen (O2) gas mixture were assessed. Sixteen patients with PD, 16 patients with SP,...
journal_title:Psychiatry research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0165-1781(97)00038-3
更新日期:1997-06-16 00:00:00
abstract::Lithium alone has previously been shown to effect antipsychotic response in approximately one-quarter of mood incongruent psychoses. Such lithium-responsive psychoses and/or the antipsychotic effects of lithium appear to be seasonal, with maximal response rates occurring in the 3-month periods surrounding January and ...
journal_title:Psychiatry research
pub_type: 临床试验,杂志文章
doi:10.1016/0165-1781(88)90122-9
更新日期:1988-12-01 00:00:00
abstract::A key characteristic of bipolar disorder is fluctuation in mood symptoms and functional capacity, yet assessment of bipolar symptomatology often relies heavily on interval measurement that is unable to capture the full range of daily symptom variability and severity. The current study provides a detailed analysis of t...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2014.04.047
更新日期:2014-08-30 00:00:00
abstract::The limbic system plays an important role in regulating the hypothalamic-pituitary-adrenal (HPA) axis as well as aspects of emotion, and both neuroendocrine disturbance and increased negative emotionality are associated with risk for developing affective disorders. However, the extent to which the architecture of conn...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2011.07.015
更新日期:2012-01-30 00:00:00
abstract::The aim of this study was to investigate the blood lead level and parental marital status that might influence the development of attention-deficit/hyperactivity disorder (ADHD) symptoms in school-aged children. The participants in the survey included elementary school children, and they were followed up biennially. T...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.01.002
更新日期:2016-02-28 00:00:00
abstract::Two animal tests of anxiety (the elevated plus-maze and the social interaction test) were used to investigate the effects of several antipanic agents. In the elevated plus-maze, the triazolobenzodiazepines adinazolam (2 and 5 mg/kg) and alprazolam (1 mg/kg), tested after 5 days of pretreatment, demonstrated significan...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(88)90161-8
更新日期:1988-07-01 00:00:00
abstract::We examined midbrain, medial temporal lobe, and basal ganglia serotonin transporter (SERT) distribution volume ratio (DVR) values in subjects with major depressive disorder versus healthy volunteers using a selective SERT radioligand and single photon emission computed tomography (SPECT). We hypothesized that the DVR ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2011.12.015
更新日期:2012-05-31 00:00:00
abstract::Several investigations have reported associations between serotonin 1A (5-HT1A) receptor and major psychiatric disorders, such as schizophrenia and bipolar disorder (BP), making the 5-HT1A receptor gene (HTR1A) a good candidate gene for the pathophysiology of schizophrenia and BP. To evaluate the association between H...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2010.06.003
更新日期:2011-01-30 00:00:00
abstract::Increased serotonergic activity in animals has been associated with a variety of stereotyped motor behaviors. In addition, serotonin facilitates brainstem, reticular, and spinal motor neuronal activity implicated in the expression of these behaviors. This report presents positive correlations between both peripheral (...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(85)90018-6
更新日期:1985-03-01 00:00:00
abstract::Vascular dementia (VaD) is characteristic of chronic brain ischemia and progressive memory decline, which has a high incidence in the elderly. However, there are no effective treatments for VaD, and the underlying mechanism of its pathogenesis remains unclear. This study investigated the effects of a synthetic cannabi...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.06.012
更新日期:2018-09-01 00:00:00
abstract::Only few studies addressing the biological background of adjustment disorder (AD) exist. We examined the psychophysiological correlates indicative of autonomic regulation in AD. Heart rate variability (HRV), skin conductance, skin temperature, electromyography, and respiration were measured during serial stress tasks ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2017.12.065
更新日期:2018-03-01 00:00:00
abstract::The seven-factor model of personality developed by Cloninger and colleagues describes personality as a function of developmental aspects of character superimposed on heritable dimensions of temperament. The objective of this study was to determine whether this model could be applied to early childhood. We tested a pre...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(02)00008-2
更新日期:2002-04-15 00:00:00