Abstract：
:There has been a long-standing interest in plasma prolactin as a potential in vivo indicator of blockade of tuberoinfundibular D2 dopamine receptors. Potential relationships between prolactin response and neuroleptic treatment have been obscured by the use of high doses which have caused prolactin to plateau. With lower doses of neuroleptic now commonly in use, prolactin may be more valuable as a correlate of clinical response. In this study, 23 acutely exacerbated schizophrenic and schizoaffective patients were washed out for at least 6 days and were then treated with haloperidol to achieve fixed low to moderate plasma levels under double-blind conditions. Clinical response, plasma prolactin, and haloperidol plasma levels were measured weekly for 3 weeks. Clinical symptoms at endpoint were related to both prolactin change and final prolactin level during haloperidol treatment. Specifically, fewer symptoms at endpoint were associated with a greater increase in prolactin over time and a higher prolactin level at endpoint. Thus, prolactin increase caused by low to moderate doses of haloperidol may be a correlate of endpoint symptomatology. As lower doses of typical neuroleptics are now in use, prolactin response as a predictor of clinical response may have more clinical utility. Further study of prolactin and clinical response to typical neuroleptics should focus on low neuroleptic doses.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Chou JC,Douyon R,Czobor P,Volavka J,Cooper TBdoi
10.1016/s0165-1781(98)00085-7subject
Has Abstractpub_date
1998-10-19 00:00:00pages
51-5issue
1eissn
0165-1781issn
1872-7123pii
S0165-1781(98)00085-7journal_volume
81pub_type
临床试验,杂志文章abstract：OBJECTIVE:To examine the construct validity of the 9 item Traumatic Events Questionnaire (TEQ) and to evaluate the extent to which experiences of trauma assessed using the TEQ are associated with symptoms of psychiatric disorders among 3342 pregnant women in Lima, Peru. METHODS:Symptoms of depression were assessed usi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.08.016
更新日期：2017-11-01 00:00:00
abstract：:This study examines sexual behavior, serotonin turnover in the central nervous system, and testosterone in free-ranging non-human primates. Study subjects were 33 young adult male rhesus macaques (Macaca mulatta) living in naturalistic social groups on a 475-acre South Carolina barrier island. Blood and cerebrospinal ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(97)00084-x
更新日期：1997-09-19 00:00:00
abstract：:This study examined the effects of neuroleptic medication on the allocation of attentional resources to distracting stimuli in patients with schizophrenia. Twenty-five patients were tested twice (medication-free and after medication stabilization) on the Identical Pairs versions of the Continuous Performance Test unde...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(95)02590-s
更新日期：1995-07-28 00:00:00
abstract：:Although many treatments for Major Depressive Disorder (MDD) exist, only half of all patients respond to initial trial of pharmacotherapy and only a third will achieve remission with that trial. First-line therapies for the management of MDD include psychotherapy or pharmacotherapy, alone or in combination. Given the ...
journal_title：Psychiatry research
pub_type： 社论
doi：10.1016/S0165-1781(14)70001-0
更新日期：2014-12-01 00:00:00
abstract：:In this study, we investigated whether polymorphisms of the dopamine D4 receptor (DRD4) gene were associated with psychotic symptomatology rather than with a unique diagnosis such as schizophrenia. A number of association studies between the DRD4 gene 48 bp-VNTR polymorphism at exon 3 and psychotic disorders have been...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.12.011
更新日期：2007-12-03 00:00:00
abstract：:Lithium alone has previously been shown to effect antipsychotic response in approximately one-quarter of mood incongruent psychoses. Such lithium-responsive psychoses and/or the antipsychotic effects of lithium appear to be seasonal, with maximal response rates occurring in the 3-month periods surrounding January and ...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/0165-1781(88)90122-9
更新日期：1988-12-01 00:00:00
abstract：:In people with schizophrenia several factors are associated with poor quality of life (QoL), namely, lifestyle-related factors and psychological factors. However, there has been little research on the impact of these factors on QoL. Therefore, the relation between lifestyle-related factors, psychological factors, and ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.06.022
更新日期：2018-09-01 00:00:00
abstract：:The current study aims to further evaluate the psychometric properties of the Maryland Assessment of Recovery in Serious Mental Illness (MARS), a relatively new instrument designed to assess personal recovery status in individuals with serious mental illness. Two hundred and fifty individuals with serious mental illne...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.03.031
更新日期：2016-05-30 00:00:00
abstract：:Deficient inhibitory neurotransmission of gamma-aminobutyric acid (GABA) has been implicated in the pathophysiology of schizophrenia based on postmortem studies. However, in vivo studies have shown predominantly negative or conflicting results. The goal of this study was to better characterize possible changes of the ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(99)00027-x
更新日期：1999-10-11 00:00:00
abstract：:In Vietnam, stigmatisation and discrimination of patients with mental illness are highly prevalent. This study explores whether the perception of course of illness of people with symptoms indicating schizophrenia is associated with the desire for social distance in the Vietnamese public. A population-based survey (n =...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.05.046
更新日期：2018-10-01 00:00:00
abstract：:Plasma levels of homovanillic acid (HVA), a dopamine metabolite, were examined in 19 psychiatric inpatients during maintenance treatment on neuroleptic medications. A significant positive correlation was found between the level of HVA and the severity of tardive dyskinesia (TD) in these patients. Seven patients had th...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(83)90046-x
更新日期：1983-07-01 00:00:00
abstract：:This investigation aimed to determine whether impaired insight influences the validity of self-report test scores in schizophrenia and schizoaffective disorder. 274 outpatients enrolled in work rehabilitation completed the Beck Depression Inventory (BDI), Eysenck Personality Questionnaire (EPQ), Bell Object Relations ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.04.012
更新日期：2007-05-30 00:00:00
abstract：:Sleep-related prolactin secretion and prolactin responses to the infusion of low doses of the dopamine antagonist, metoclopramide, and thyrotropin-releasing hormone were measured in 11 female volunteers before and after undertaking a diet in which they lost a mean of 3.1 kg in weight in 3 weeks. No effect of weight lo...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(89)90030-9
更新日期：1989-08-01 00:00:00
abstract：:Destination memory refers to the ability to remember to whom a piece of information was previously transmitted. Our paper assessed this ability in schizophrenia. Twenty-five patients with schizophrenia and 25 control participants told proverbs (e.g., "send a thief to catch a thief") to pictures of celebrities (e.g., E...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.12.023
更新日期：2017-02-01 00:00:00
abstract：:There is a need for theoretically-based research on the motivational processes linked to the adoption and maintenance of an active lifestyle in people with affective disorders. Within the Self-Determination Theory (SDT) framework, we investigated the SDT tenets in people with major depressive disorder or bipolar disor...
journal_title：Psychiatry research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.psychres.2015.04.021
更新日期：2015-07-30 00:00:00
abstract：:Our study aimed to examine the interplay between clinical and social predictors of future suicide attempt and the transition from suicidal ideation to suicide attempt in depressive disorders. Sixty-six Malaysian inpatients with a depressive disorder were assessed at index admission and within 1 year for suicide attemp...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.08.055
更新日期：2014-12-30 00:00:00
abstract：:Maternal depression has been intensively explored; however, less attention has been paid to maternal suicide. No studies to date have observed maternal depression and suicide at immediate prenatal and early postpartum stages. In total, 213 Chinese women were recruited in hospitals after they were admitted for childbir...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.12.085
更新日期：2018-03-01 00:00:00
abstract：:This study aimed to determine whether (1) cognitive behavioural therapy with behavioural analysis for insomnia (CBTi-BA) is more effective for insomnia and co-morbid depressive symptoms than treatment as usual (TAU) and (2) whether CBTi-BA promotes earlier reduction of the daily dose of hypnotic medication in chronic ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.06.028
更新日期：2013-12-15 00:00:00
abstract：:This study was designed to assess cognitive functioning in a clinical sample of adolescents with heterogeneous psychiatric diagnoses, with a specific focus on patients at clinical high risk (CHR) for psychosis. The sample comprised 22 patients identified at CHR for psychosis, 67 psychotic and 187 non-psychotic, non-CH...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2009.04.011
更新日期：2010-09-30 00:00:00
abstract：:In this study, we evaluated the efficacy of mindfulness-based stress reduction (MBSR) for young people with anxiety symptoms. We used many databases, including PubMed, PsycINFO, Web of Science, EMBASE, CINAHL and Cochrane Library (from inception to May 2019). We included randomized controlled trials (RCTs) comparing M...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.psychres.2020.113002
更新日期：2020-07-01 00:00:00
abstract：:This study compared basal concentrations of plasma beta-endorphin/beta-lipotropin-like immunoreactivity and dexamethasone suppression of cortisol in seven chronic pain patients, seven psychiatric disorder patients, and seven normal volunteers. Pain patients and psychiatric patients showed significantly higher basal co...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(83)90005-7
更新日期：1983-08-01 00:00:00
abstract：:The planimetric measurement of the area of the ventricles on a computed tomographic section is a convenient and useful method of assessing ventricular size when more sophisticated techniques are not available. It is commonly reported as a planimetric ventricular-brain ratio or VBR. Ventricular size is related to crani...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(83)90064-1
更新日期：1983-03-01 00:00:00
abstract：:Social cognition is impaired in schizophrenia, is relatively independent of purely neurocognitive domains such as attention and executive functioning, and may be the strongest predictor of functional outcome in this disease. Within a motivated reasoning framework, we tested the hypothesis that the anti-inflammatory Th...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.02.030
更新日期：2017-05-01 00:00:00
abstract：:Childhood adversities are key etiological factors in the onset and persistence of psychopathology. In Northern Ireland the Troubles also impacted on the population's psychological health. This study used data from the Northern Ireland Study of Health and Stress a collaborative epidemiological study which used the WMH-...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.02.024
更新日期：2018-04-01 00:00:00
abstract：:Depressive symptoms are associated with deficits in objectively-rated detail and specificity in autobiographical future thinking for personally-relevant events. However, how depressive symptoms might affect the subjective, phenomenal characteristics of future thinking in general is not well understood. This study exam...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.12.100
更新日期：2019-03-01 00:00:00
abstract：:This report of a pilot study examines 29 pairs of twins from a population-based registry on whom four domains of schizotypy have been measured: personal interview using the Structured Interview for Schizotypy, self-report questionnaire formed from eight published self-report scales, attentional battery of eight indivi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(91)90114-5
更新日期：1991-01-01 00:00:00
abstract：:Computed tomographic (CT) scans of brains of patients with borderline personality disorder and normal volunteers were analyzed for ventricle-brain ratios, third ventricular size, and evidence of frontal lobe atrophy. There were no significant differences between the two groups on any of these measures except for a nar...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(89)90126-1
更新日期：1989-02-01 00:00:00
abstract：:Aerobic exercise (AE) has been shown to improve cognition in patients with schizophrenia. However, it remains unclear whether these exercise-induced cognitive benefits persist beyond the training period. Accordingly, the present study sought to examine the immediate and maintenance effects of AE on a wide range of cog...
journal_title：Psychiatry research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.psychres.2016.08.011
更新日期：2016-10-30 00:00:00
abstract：:Platelet imipramine binding was measured in 25 unmedicated depressed patients and 25 age- and sex-matched healthy controls. In the patients, the measurement was repeated after 3 weeks and 2 months of imipramine treatment leading to clinical recovery. No significant differences in imipramine binding were found between ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(90)90040-c
更新日期：1990-09-01 00:00:00
abstract：:The severity of depressive symptoms across two discrete mental disorders should be evaluated with the same psychometrically validated tools. In patients with schizophrenia the Calgary Depression Rating Scale (CDSS) is recommended for evaluating depressive symptoms. The aim of this study was to validate the CDSS in pat...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.06.062
更新日期：2018-10-01 00:00:00
